Search Results - "Głowacka, Urszula"
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Prolonged Dysfunction of Astrocytes and Activation of Microglia Accelerate Degeneration of Dopaminergic Neurons in the Rat Substantia Nigra and Block Compensation of Early Motor Dysfunction Induced by 6-OHDA
Published in Molecular neurobiology (01-04-2018)“…Progressive degeneration of dopaminergic neurons in the substantia nigra (SN) is the underlying cause of Parkinson’s disease (PD). The disease in early stages…”
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Increased Beta-Hydroxybutyrate Level Is Not Sufficient for the Neuroprotective Effect of Long-Term Ketogenic Diet in an Animal Model of Early Parkinson’s Disease. Exploration of Brain and Liver Energy Metabolism Markers
Published in International journal of molecular sciences (14-07-2021)“…The benefits of a ketogenic diet in childhood epilepsy steered up hope for neuroprotective effects of hyperketonemia in Parkinson’s disease (PD). There are…”
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Astrocyte support is important for the compensatory potential of the nigrostriatal system neurons during early neurodegeneration
Published in Journal of neurochemistry (01-01-2019)“…Glial pathology precedes symptoms of Parkinson's disease and multiple other neurodegenerative diseases. Prolonged impairment of astrocytic functions could…”
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The impact of voluntary wheel-running exercise on hippocampal neurogenesis and behaviours in response to nicotine cessation in rats
Published in Psychopharmacology (01-12-2024)“…Rationale The literature indicates that nicotine exposure or its discontinuation impair adult hippocampal neurogenesis in rats, though the impact of exercise…”
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Synergisms, Discrepancies and Interactions between Hydrogen Sulfide and Carbon Monoxide in the Gastrointestinal and Digestive System Physiology, Pathophysiology and Pharmacology
Published in Biomolecules (Basel, Switzerland) (13-03-2020)“…Endogenous gas transmitters, hydrogen sulfide (H S), carbon monoxide (CO) and nitric oxide (NO) are important signaling molecules known to exert multiple…”
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Alterations of BDNF and trkB mRNA expression in the 6-hydroxydopamine-induced model of preclinical stages of Parkinson's disease: an influence of chronic pramipexole in rats
Published in PloS one (04-03-2015)“…Our recent study has indicated that a moderate lesion of the mesostriatal and mesolimbic pathways in rats, modelling preclinical stages of Parkinson's disease,…”
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Chronic Lorcaserin Treatment Reverses the Nicotine Withdrawal-Induced Disruptions to Behavior and Maturation in Developing Neurons in the Hippocampus of Rats
Published in International journal of molecular sciences (16-01-2021)“…Preclinical data have shown that treatment with serotonin (5-HT) receptor agonists inhibits the behavioral effects of nicotine, including self-administration,…”
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Adolescent social isolation affects parvalbumin expression in the medial prefrontal cortex in the MAM-E17 model of schizophrenia
Published in Metabolic brain disease (01-02-2019)“…Altered parvalbumin (PV) expression is observed in the prefrontal cortex of subjects with schizophrenia. Environmental context, particularly during…”
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Adaptation within mitochondrial oxidative phosphorylation supercomplexes and membrane viscosity during degeneration of dopaminergic neurons in an animal model of early Parkinson's disease
Published in Biochimica et biophysica acta (01-04-2016)“…In Parkinson's disease (PD) motor symptoms are not observed until loss of 70% of dopaminergic neurons in substantia nigra (SN), preventing early diagnosis…”
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Apomorphine enhances harmaline-induced tremor in rats
Published in Pharmacological reports (01-06-2015)“…Harmaline-induced tremor is a well-known model of essential tremor in humans. The aim of the present study was to examine the influence of apomorphine, a…”
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Adolescent Social Isolation Affects Schizophrenia-Like Behavior in the MAM-E17 Model of Schizophrenia
Published in Neurotoxicity research (01-08-2018)“…Social isolation (SI) during adolescence may induce schizophrenia-like behavior. In the present study, we investigated whether adolescent SI might affect the…”
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Physiological healing of chronic gastric ulcer is not impaired by the hydrogen sulphide (H2S)-releasing derivative of acetylsalicylic acid (ATB-340): functional and proteomic approaches
Published in Inflammopharmacology (01-06-2024)“…Gastric ulcers affect approx. 10% of population. Non-steroidal anti-inflammatory drugs (NSAIDs), including acetylsalicylic acid (ASA) predispose to or impair…”
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Tremorolytic effect of 5′‐chloro‐5′‐deoxy‐(±)‐ENBA, a potent and selective adenosine A1 receptor agonist, evaluated in the harmaline‐induced model in rats
Published in CNS neuroscience & therapeutics (01-05-2017)“…Summary Aim The aim of this study was to examine the role of adenosine A1 receptors in the harmaline‐induced tremor in rats using 5′‐chloro‐5′‐deoxy‐(±)‐ENBA…”
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Pramipexole but not imipramine or fluoxetine reverses the “depressive-like” behaviour in a rat model of preclinical stages of Parkinson's disease
Published in Behavioural brain research (01-09-2014)“…•6-OHDA-induced moderate dopamine lesion evoked depressive-like behaviour in rats.•Repeated pramipexole induced an antidepressant-like effect in…”
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Pramipexole at a Low Dose Induces Beneficial Effect in the Harmaline‐induced Model of Essential Tremor in Rats
Published in CNS neuroscience & therapeutics (01-01-2016)“…Summary Aims The aim of the study was to examine the effects of preferential agonists of dopamine D3 receptors: pramipexole and 7‐OH‐DPAT on the…”
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Lu AF21934, a positive allosteric modulator of mGlu4 receptors, reduces the harmaline-induced hyperactivity but not tremor in rats
Published in Neuropharmacology (01-08-2014)“…Harmaline induces tremor in animals resembling essential tremor which has been suggested to result from activation of the glutamatergic olivo-cerebellar…”
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Organic carbon monoxide prodrug, BW-CO-111, in protection against chemically-induced gastric mucosal damage
Published in Acta pharmaceutica Sinica. B (01-02-2021)“…Metal-based carbon monoxide (CO)-releasing molecules have been shown to exert anti-inflammatory and anti-oxidative properties maintaining gastric mucosal…”
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Hydrogen Sulfide-Releasing Indomethacin-Derivative (ATB-344) Prevents the Development of Oxidative Gastric Mucosal Injuries
Published in Antioxidants (01-08-2023)“…Hydrogen sulfide (H2S) emerged recently as an anti-oxidative signaling molecule that contributes to gastrointestinal (GI) mucosal defense and repair…”
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Evidence for Cytoprotective Effect of Carbon Monoxide Donor in the Development of Acute Esophagitis Leading to Acute Esophageal Epithelium Lesions
Published in Cells (Basel, Switzerland) (12-05-2020)“…Exposure to acidic gastric content due to malfunction of lower esophageal sphincter leads to acute reflux esophagitis (RE) leading to disruption of esophageal…”
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Hydrogen sulfide as a modulator of mitochondrial activity in the protection against oxidative NSAIDs-induced gastric injury
Published in Free radical biology & medicine (20-02-2022)Get full text
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