Search Results - "Güzel, Özlen"

Discovery of Low Nanomolar and Subnanomolar Inhibitors of the Mycobacterial β-Carbonic Anhydrases Rv1284 and Rv3273 by Güzel, Özlen, Maresca, Alfonso, Scozzafava, Andrea, Salman, Aydın, Balaban, Alexandru T, Supuran, Claudiu T

“…A series of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides has been derivatized by reaction with 2,4,6-trimethylpyrylium perchlorate, leading to…”
Get full text

Synthesis of new spiroindolinones incorporating a benzothiazole moiety as antioxidant agents by Karalı, Nilgün, Güzel, Özlen, Özsoy, Nurten, Özbey, Süheyla, Salman, Aydın

“…3 H-Spiro[1,3-benzothiazole-2,3′-indol]-2′(1′ H)-ones 3a– c and 4a– e were synthesized from treating the 5-substituted 1 H-indole-2,3-diones with…”
Get full text

Synthesis and antituberculosis activity of 5-methyl/trifluoromethoxy-1H-indole-2,3-dione 3-thiosemicarbazone derivatives by Güzel, Ozlen, Karali, Nilgün, Salman, Aydin

“…New series of 5-methyl/trifluoromethoxy-1H-indole-2,3-dione 3-thiosemicarbazones 3a-t, 1-methyl-5-methyl/trifluoromethoxy-1H-indole-2,3-dione…”
Get full text

Development of Thiazolidinones as Fungal Carbonic Anhydrase Inhibitors by Güzel-Akdemir, Özlen, Carradori, Simone, Grande, Rossella, Demir-Yazıcı, Kübra, Angeli, Andrea, Supuran, Claudiu T, Akdemir, Atilla

“…In our efforts to find new and selective thiazolidinone-based anti- agents, we synthesized and tested 26 thiazolidinones against several spp. and Gram-positive…”
Get full text

Indole-Based Hydrazones Containing A Sulfonamide Moiety as Selective Inhibitors of Tumor-Associated Human Carbonic Anhydrase Isoforms IX and XII by Demir-Yazıcı, Kübra, Bua, Silvia, Akgüneş, Nurgül Mutlu, Akdemir, Atilla, Supuran, Claudiu T, Güzel-Akdemir, Özlen

“…Novel sulfonamidoindole-based hydrazones with a 2-(hydrazinocarbonyl)-3-phenyl-1 -indole-5-sulfonamide scaffold were synthesized and tested in enzyme…”
Get full text

Novel Indole-Based Hydrazones as Potent Inhibitors of the α-class Carbonic Anhydrase from Pathogenic Bacterium Vibrio cholerae by Demir-Yazıcı, Kübra, Güzel-Akdemir, Özlen, Angeli, Andrea, Supuran, Claudiu T, Akdemir, Atilla

“…Due to the increasing resistance of currently used antimicrobial drugs, there is an urgent problem for the treatment of cholera disease, selective inhibition…”
Get full text

Synthesis, antimycobacterial and antitumor activities of new (1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)methyl N,N-disubstituted dithiocarbamate/O-alkyldithiocarbonate derivatives by Güzel, Özlen, Salman, Aydın

“…Reaction of 2-chloromethylsaccharin with substituted potassium dithiocarbamates and substituted potassium dithiocarbonates furnished…”
Get full text

Novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group acting as human carbonic anhydrase IX inhibitors by Güzel-Akdemir, Özlen, Angeli, Andrea, Demir, Kübra, Supuran, Claudiu T., Akdemir, Atilla

“…A small collection of 26 structurally novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group, were synthesised and…”
Get full text

Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB by Güzel, Özlen, Innocenti, Alessio, Scozzafava, Andrea, Salman, Aydın, Supuran, Claudiu T.

“…K i (hCA I) = 263 nM, K i (hCA II) = 395 nM K i (hCA VA) = 7.1 nM, Ki (hCA VB) = 5.9 nM. A series of aromatic/heterocyclic sulfonamides incorporating…”
Get full text

Synthesis and antibacterial activity of new hybrid derivatives of 5-sulfamoyl-1H-indole and 4-thiazolidinone groups by Güzel-Akdemir, Özlen, Trawally, Muhammed, Özbek-Babuç, Mehtap, Özbek-Çelik, Berna, Ermut, Görkem, Özdemir, Hakan

“…The synthesis of a series of new 3-phenyl-5-sulfamoyl- N -(7/8/9-(non)substituted-3-oxo-1-thia-4-azaspiro[4.4]non/[4.5]dec-4-yl)-1 H -indole-2-carboxamide…”
Get full text

Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with 12 mammalian isoforms : Kinetic and X-ray crystallographic studies by GÜZEL, Ozlen, TEMPERINI, Claudia, INNOCENTI, Alessio, SCOZZAFAVA, Andrea, SALMAN, Aydin, SUPURAN, Claudiu T

“…2-(Hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide was tested for its interaction with 12 carbonic anhydrase (CA, EC 4.2.1.1) isoforms in the search of…”
Get full text

Carbonic anhydrase inhibitors. Phenacetyl-, pyridylacetyl- and thienylacetyl-substituted aromatic sulfonamides act as potent and selective isoform VII inhibitors by Güzel, Özlen, Innocenti, Alessio, Scozzafava, Andrea, Salman, Aydın, Supuran, Claudiu T.

“…K i (hCA I) = 108 nM, K i (hCA II) = 107 nM K i (hCA VII) = 4.7 nM. A series of aromatic/heterocyclic sulfonamides incorporating phenyl(alkyl),…”
Get full text

Synthesis and biological evaluation of new 4-thiazolidinone derivatives by Güzel, Ozlen, Salman, Aydin

“…A series of new 2-aryl-4-thiazolidinones (3 and 4) was synthesized from 2-hydroxy-2,2-diphenyl-N'-[(substituted phenyl)methylene]acetohydrazides (2) and…”
Get more information

Carbonic anhydrase inhibitors. The beta-carbonic anhydrases from the fungal pathogens Cryptococcus neoformans and Candida albicans are strongly inhibited by substituted-phenyl-1H-indole-5-sulfonamides by Güzel, Ozlen, Maresca, Alfonso, Hall, Rebecca A, Scozzafava, Andrea, Mastrolorenzo, Antonio, Mühlschlegel, Fritz A, Supuran, Claudiu T

“…A series of 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides and 1-({[5-(aminosulfonyl)-3-phenyl-1H-indol-2-yl]carbonyl}amino)-2,4,6…”
Get full text

Carbonic anhydrase inhibitors : Synthesis and inhibition studies against mammalian isoforms I-XV with a series of 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides by GÜZEL, Ozlen, INNOCENTI, Alessio, SCOZZAFAVA, Andrea, SALMAN, Aydin, PARKKILA, Seppo, HILVO, Mika, SUPURAN, Claudiu T

“…A series of 2-(hydrazinocarbonyl)-3-substitutedphenyl-1H-indole-5-sulfonamides possessing various 2-, 3- or 4- substituted phenyl groups with methyl-,…”
Get full text

Carbonic anhydrase inhibitors. Synthesis of 2,4,6-trimethylpyridinium derivatives of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides acting as potent inhibitors of the tumor-associated isoform IX and XII by Güzel, Özlen, Maresca, Alfonso, Scozzafava, Andrea, Salman, Aydın, Balaban, Alexandru T., Supuran, Claudiu T.

“…KI (hCA I)=7.6nM; KI (hCA II)=65nM, KI (hCA IX)=8.3nM; KI (hCA XII)=9.5nM. A series of 2-(hydrazinocarbonyl)-3-aryl-1H-indole-5-sulfonamides possessing various…”
Get full text

3-phenyl-1H-indole-5-sulfonamides: structure-based drug design of a promising class of carbonic anhydrase inhibitors by Güzel, Ozlen, Innocenti, Alessio, Vullo, Daniela, Scozzafava, Andrea, Supuran, Claudiu T

“…A series of 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides possessing various 2-, 3- or 4- substituted phenyl groups with methyl-,…”
Get more information

Carbonic anhydrase inhibitors. The nematode alpha-carbonic anhydrase of Caenorhabditis elegans CAH-4b is highly inhibited by 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides by Güzel, Ozlen, Innocenti, Alessio, Hall, Rebecca A, Scozzafava, Andrea, Mühlschlegel, Fritz A, Supuran, Claudiu T

“…A series of 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides possessing various 2-, 3- or 4-substituted phenyl groups with methyl-,…”
Get full text

Synthesis and Antimycobacterial Activity of New 2-Hydroxy-N-(3-oxo-1-thia-4-azaspiro[4.4]non-4-yl)/(3-oxo-1-thia-4-azaspiro[4.5]dec-4-yl)-2,2-diphenylacetamide Derivatives by Güzel, Özlen, İlhan, Eser, Salman, Aydın

Get full text

Synthesis and biological evaluation of new 5-methyl-N-(3-oxo-1-thia-4-azaspiro[4.5]-dec-4-yl)-3-phenyl-1H-indole-2-carboxamide derivatives by Güzel, Özlen, Terzioğlu, Nalan, Çapan, Gültaze, Salman, Aydın

Get full text