Search Results - "Güther, M. Lucia S."

The Synthesis of UDP-N-acetylglucosamine Is Essential for Bloodstream Form Trypanosoma brucei in Vitro and in Vivo and UDP-N-acetylglucosamine Starvation Reveals a Hierarchy in Parasite Protein Glycosylation by Stokes, Matthew J., Güther, M. Lucia S., Turnock, Daniel C., Prescott, Alan R., Martin, Kirstee L., Alphey, Magnus S., Ferguson, Michael A.J.

“…A gene encoding Trypanosoma brucei UDP-N-acetylglucosamine pyrophosphorylase was identified, and the recombinant protein was shown to have enzymatic activity…”
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Comparative SILAC proteomic analysis of Trypanosoma brucei bloodstream and procyclic lifecycle stages by Urbaniak, Michael D, Guther, M Lucia S, Ferguson, Michael A J

“…The protozoan parasite Trypanosoma brucei has a complex digenetic lifecycle between a mammalian host and an insect vector, and adaption of its proteome between…”
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Deletion of the TbALG3 gene demonstrates site-specific N-glycosylation and N-glycan processing in Trypanosoma brucei by Manthri, Sujatha, Güther, M. Lucia S, Izquierdo, Luis, Acosta-Serrano, Alvaro, Ferguson, Michael A.J

“…We recently suggested a novel site-specific N-glycosylation mechanism in Trypanosoma brucei whereby some protein N-glycosylation sites selectively receive…”
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Myristoyl-CoA:protein N-myristoyltransferase depletion in trypanosomes causes avirulence and endocytic defects by Price, Helen P., Güther, M. Lucia S., Ferguson, Michael A.J., Smith, Deborah F.

“…The enzyme myristoyl-CoA:protein N-myristoyltransferase (NMT) catalyses the co-translational covalent attachment of the fatty acid myristate to the N-terminus…”
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The Suppression of Galactose Metabolism in Procylic Form Trypanosoma brucei Causes Cessation of Cell Growth and Alters Procyclin Glycoprotein Structure and Copy Number by Roper, Janine R., Güther, M. Lucia S., MacRae, James I., Prescott, Alan R., Hallyburton, Irene, Acosta-Serrano, Alvaro, Ferguson, Michael A.J.

“…Galactose metabolism is essential in bloodstream form Trypanosoma brucei and is initiated by the enzyme UDP-Glc 4′-epimerase. Here, we show that the parasite…”
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A Gene of the β3-Glycosyltransferase Family Encodes N-Acetylglucosaminyltransferase II Function in Trypanosoma brucei by Damerow, Manuela, Graalfs, Frauke, Güther, M. Lucia S., Mehlert, Angela, Izquierdo, Luis, Ferguson, Michael A.J.

“…The bloodstream form of the human pathogen Trypanosoma brucei expresses oligomannose, paucimannose, and complex N-linked glycans, including some exceptionally…”
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N -myristoyltransferase inhibitors as new leads to treat sleeping sickness by Cleghorn, Laura A. T, Torrie, Leah S, Frearson, Julie A, Guther, M. Lucia S, Smid, Ondrej, Smith, Deborah F, Stojanovski, Laste, Wilkinson, Anthony J, Wyatt, Paul G, Brannigan, James A, Hui, Raymond, Brand, Stephen, Raimi, Olawale G, Brenk, Ruth, Robinson, David A, Hodgkinson, Michael, Ferguson, Michael A. J, Hallyburton, Irene, Mpamhanga, Chidochangu P, Gilbert, Ian H, McElroy, Stuart P, van Aalten, Daan M. F, Qiu, Wei, Read, Kevin D, Price, Helen P, Fairlamb, Alan H

“…African sleeping sickness or human African trypanosomiasis, caused by Trypanosoma brucei spp., is responsible for ∼30,000 deaths each year. Available…”
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Deletion of the GPIdeAc Gene Alters the Location and Fate of Glycosylphosphatidylinositol Precursors in Trypanosoma brucei by Güther, M. Lucia S, Prescott, Alan R, Ferguson, Michael A. J

“…Glycosylphosphatidylinositol (GPI) membrane anchors are ubiquitous among the eukaryotes. In most organisms, the pathway of GPI biosynthesis involves inositol…”
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Identification and Functional Characterization of a Highly Divergent N-Acetylglucosaminyltransferase I (TbGnTI) in Trypanosoma brucei by Damerow, Manuela, Rodrigues, Joao A., Wu, Di, Güther, M.Lucia S., Mehlert, Angela, Ferguson, Michael A.J.

“…Trypanosoma brucei expresses a diverse repertoire of N-glycans, ranging from oligomannose and paucimannose structures to exceptionally large complex N-glycans…”
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Deletion of the Glucosidase II Gene in Trypanosoma brucei Reveals Novel N-Glycosylation Mechanisms in the Biosynthesis of Variant Surface Glycoprotein by Jones, Deuan C., Mehlert, Angela, Güther, M. Lucia S., Ferguson, Michael A.J.

“…The trypanosomatids are generally aberrant in their protein N-glycosylation pathways. However, protein N-glycosylation in the African trypanosome Trypanosoma…”
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Creation and characterization of glycosyltransferase mutants of Trypanosoma brucei by Izquierdo, Luis, Güther, M Lucia S, Ferguson, Michael A J

“…The survival strategies of protozoan parasites frequently involve the participation of glycoconjugates. Trypanosoma brucei expresses complex glycoproteins…”
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The Synthesis of UDP-N-acetylglucosamine Is Essential for Bloodstream Form Trypanosoma brucei in Vitro and in Vivo and UDP-N-acetylglucosamine Starvation Reveals a Hierarchy in Parasite Protein GlycosylationS by Stokes, Matthew J., Güther, M. Lucia S., Turnock, Daniel C., Prescott, Alan R., Martin, Kirstee L., Alphey, Magnus S., Ferguson, Michael A. J.

“…A gene encoding Trypanosoma brucei UDP- N -acetylglucosamine pyrophosphorylase was identified, and the recombinant protein was shown to have enzymatic…”
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The GPI biosynthetic pathway as a therapeutic target for African sleeping sickness by Ferguson, Michael A.J., Brimacombe, John S., Brown, Jillian R., Crossman, Arthur, Dix, Alexander, Field, Robert A., Güther, M.Lucia S., Milne, Kenneth G., Sharma, Deepak K., Smith, Terry K.

“…African sleeping sickness is a debilitating and often fatal disease caused by tsetse fly transmitted African trypanosomes. These extracellular protozoan…”
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A gene of the beta3-glycosyltransferase family encodes N-acetylglucosaminyltransferase II function in Trypanosoma brucei by Damerow, Manuela, Graalfs, Frauke, Guther, M. Lucia S, Mehlert, Angela, Izquierdo, Luis, Ferguson, Michael A. J

“…The bloodstream form of the human pathogen Trypanosoma brucei expresses oligomannose, paucimannose and complex N-linked glycans, including some exceptionally…”
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