Search Results - "Günzel, D"

Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease by Zeissig, S, Bürgel, N, Günzel, D, Richter, J, Mankertz, J, Wahnschaffe, U, Kroesen, A J, Zeitz, M, Fromm, M, Schulzke, J-D

“…Background: Epithelial barrier function is impaired in Crohn’s disease. Aim: To define the underlying cellular mechanisms with special attention to tight…”
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Claudin‐2‐mediated cation and water transport share a common pore by Rosenthal, R., Günzel, D., Krug, S. M., Schulzke, J.‐D., Fromm, M., Yu, A. S. L.

“…Aim Claudin‐2 is a tight junction protein typically located in ‘leaky’ epithelia exhibiting large paracellular permeabilities like small intestine and proximal…”
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Claudins of intestine and nephron - a correlation of molecular tight junction structure and barrier function by Amasheh, S., Fromm, M., Günzel, D.

“…A prerequisite of epithelial transport is a paracellular barrier function, which seals the tissue against an uncontrolled leak flux. Moreover, selective…”
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Assembly of Tight Junction Strands: Claudin-10b and Claudin-3 Form Homo-Tetrameric Building Blocks that Polymerise in a Channel-Independent Manner by Hempel, C., Protze, J., Altun, E., Riebe, B., Piontek, A., Fromm, A., Lee, I.M., Saleh, T., Günzel, D., Krause, G., Piontek, J.

“…Tight junctions regulate paracellular permeability size and charge selectively. Models have been proposed for the molecular architecture of tight junction…”
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TcpC protein from E. coli Nissle improves epithelial barrier function involving PKCζ and ERK1/2 signaling in HT-29/B6 cells by Hering, N A, Richter, J F, Fromm, A, Wieser, A, Hartmann, S, Günzel, D, Bücker, R, Fromm, M, Schulzke, J D, Troeger, H

“…The probiotic Escherichia coli Nissle 1917 (EcN) is widely used to maintain remission in ulcerative colitis. This is thought to be mediated by various…”
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Intestinal insulin/IGF1 signalling through FoxO1 regulates epithelial integrity and susceptibility to colon cancer by Ostermann, A. L., Wunderlich, C. M., Schneiders, L., Vogt, M. C., Woeste, M. A., Belgardt, B. F., Niessen, C. M., Martiny, B., Schauss, A. C., Frommolt, P., Nikolaev, A., Hövelmeyer, N., Sears, R. C., Koch, P. J., Günzel, D., Brüning, J. C., Wunderlich, F. T.

“…Obesity promotes the development of insulin resistance and increases the incidence of colitis-associated cancer (CAC), but whether a blunted insulin action…”
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Restitution of single-cell defects in the mouse colon epithelium differs from that of cultured cells by Günzel, D, Florian, P, Richter, J F, Troeger, H, Schulzke, J D, Fromm, M, Gitter, A H

“…Integrity of colon epithelium is of crucial importance and, as small defects occur constantly, rapid repair (restitution) is essential. To investigate the…”
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Apparent intracellular Mg2+ buffering in neurons of the leech Hirudo medicinalis by Günzel, D, Zimmermann, F, Durry, S, Schlue, W R

“…The apparent intracellular Mg2+ buffering, or muffling (sum of processes that damp changes in the free intracellular Mg2+ concentration, [Mg2+](i), e.g.,…”
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Apparent intracellular Mg(2+) buffering in neurons of the leech Hirudo medicinalis by Gunzel, D, Zimmermann, F, Durry, S, W-R Schlue

“…The apparent intracellular Mg2+ buffering, or muffling (sum of processes that damp changes in the free intracellular Mg2+ concentration, [Mg2+]i, e.g.,…”
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Intracellular pH of crab and crayfish muscle fibre types during GABA application and inhibitory nerve stimulation by Günzel, D, Galler, S

“…The inhibitory motoneurons of crustaceans form synapses both with the sarcolemma of muscle fibres and with the very distal branchings of the excitatory…”
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Sodium-magnesium antiport in Retzius neurones of the leech Hirudo medicinalis by Guenzel, D, Schlue, W R

“…1. Intracellular free magnesium ([Mg2+]i) and sodium ([Na+]i) concentrations were measured in Retzius neurones of the leech Hirudo medicinalis using…”
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Na+-dependent regulation of the free Mg2+ concentration in neuropile glial cells and P neurones of the leech Hirudo medicinalis by Hintz, K, Günzel, D, Schlue, W R

“…To investigate the Mg2+ regulation in neuropile glial (NG) cells and pressure (P) neurones of the leech Hirudo medicinalis the intracellular free Mg2+…”
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Intracellular alkalinization causes Mg2+ release from intracellular binding sites in leech Retzius neurones by Günzel, D, Durry, S, Schlue, W R

“…Four-barrelled ion-sensitive microelectrodes were developed to enable simultaneous measurement of intracellular free Mg2+ and Na+ concentrations ([Mg2+]i,…”
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Claudins of intestine and nephron - a correlation of molecular tight junction structure and barrier function: Acta Physiologica International Symposium: acid-base transporters and epithelial electrolyte transport by AMASHEH, S, FROMM, M, GÜNZEL, D

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Apparent Intracellular Mg2+ Buffering in Neurons of the Leech Hirudo medicinalis by Günzel, D., Zimmermann, F., Durry, S., Schlue, W.-R.

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TcpC protein from E. coli Nissle improves epithelial barrier function involving PKC[zeta] and ERK1/2 signaling in HT-29/B6 cells by Hering, N A, Richter, J F, Fromm, A, Wieser, A, Hartmann, S, Günzel, D, Bücker, R, Fromm, M, Schulzke, J D, Troeger, H

“…The probiotic Escherichia coli Nissle 1917 (EcN) is widely used to maintain remission in ulcerative colitis. This is thought to be mediated by various…”
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Multi-barrelled ion-sensitive microelectrodes and their application in micro-droplets and biological systems by Günzel, D., Müller, A., Durry, S., Schlue, W.-R.

“…Multi-barrelled ion-sensitive microelectrodes were developed to enable simultaneous measurement of the free concentrations of up to three ion species and the…”
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Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Commentary by WEBER, C. R, TURNER, J. R, FROMM, M, SCHULZKE, J.-D, ZEISSIG, S, BÜRGEL, N, GÜNZEL, D, RICHTER, J, MANKERTZ, J, WAHNSCHAFFE, U, KROESEN, A. J, ZEITZ, M

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Fibre heterogeneity in the closer and opener muscles of crayfish walking legs by GÜNZEL, D, GALLER, S, RATHMAYER, W

“…ABSTRACT The closer and opener muscles in the third walking legs of the three crayfish Pacifastacus leniusculus, Procambarus clarkii and Astacus leptodactylus…”
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Mechanisms of Mg2+ influx, efflux and intracellular 'muffling' in leech neurones and glial cells by Günzel, D, Schlue, W R

“…Mg2+ is known to influence conductance and gating properties of a multitude of ion channels and is thus able to modulate synaptic transmission. Therefore, a…”
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