Search Results - "Günther, Gunar"

Regimens for Drug-Resistant Tuberculosis by Lange, Christoph, Köhler, Niklas, Günther, Gunar

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Bedaquiline Resistance after Effective Treatment of Multidrug-Resistant Tuberculosis, Namibia by Günther, Gunar, Mhuulu, Lusia, Diergaardt, Azaria, Dreyer, Viola, Moses, Maria, Anyolo, Kaarna, Ruswa, Nunurai, Claassens, Mareli, Niemann, Stefan, Nepolo, Emmanuel

“…Bedaquiline is currently a key drug for treating multidrug-resistant or rifampin-resistant tuberculosis. We report and discuss the unusual development of…”
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Defining Outcomes of Tuberculosis (Treatment): From the Past to the Future by Günther, Gunar, Heyckendorf, Jan, Zellweger, Jean Pierre, Reimann, Maja, Claassens, Mareli, Chesov, Dumitru, van Leth, Frank

“…Untreated active tuberculosis (TB) has a very high long-term mortality. Treatment of TB reduces mortality dramatically and should maximize cure, preventing…”
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Two Pandemics, One Challenge-Leveraging Molecular Test Capacity of Tuberculosis Laboratories for Rapid COVID-19 Case-Finding by Homolka, Susanne, Paulowski, Laura, Andres, Sönke, Hillemann, Doris, Jou, Ruwen, Günther, Gunar, Claassens, Mareli, Kuhns, Martin, Niemann, Stefan, Maurer, Florian P

“…In many settings, the ongoing coronavirus disease (COVID-19) pandemic coincides with other major public health threats, in particular tuberculosis. Using…”
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Clinical, Diagnostic, and Treatment Disparities between HIV-Infected and Non-HIV-Infected Immunocompromised Patients with Pneumocystis jirovecii Pneumonia by Salzer, Helmut J F, Schäfer, Guido, Hoenigl, Martin, Günther, Gunar, Hoffmann, Christian, Kalsdorf, Barbara, Alanio, Alexandre, Lange, Christoph

“…The substantial decline in the Pneumocystis jirovecii pneumonia (PCP) incidence in HIV-infected patients after the introduction of antiretroviral therapy (ART)…”
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Targeted next-generation sequencing to diagnose drug-resistant tuberculosis: a systematic review and meta-analysis by Schwab, Tiana Carina, Perrig, Lisa, Göller, Pauline Carlotta, Guebely De la Hoz, Freddy Fernando, Lahousse, Adrien Philippe, Minder, Beatrice, Günther, Gunar, Efthimiou, Orestis, Omar, Shaheed Vally, Egger, Matthias, Fenner, Lukas

“…Targeted next-generation sequencing (NGS) can rapidly and simultaneously detect mutations associated with resistance to tuberculosis drugs across multiple gene…”
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Validation and Optimization of Host Immunological Bio-Signatures for a Point-of-Care Test for TB Disease by Mutavhatsindi, Hygon, van der Spuy, Gian D, Malherbe, Stephanus T, Sutherland, Jayne S, Geluk, Annemieke, Mayanja-Kizza, Harriet, Crampin, Amelia C, Kassa, Desta, Howe, Rawleigh, Mihret, Adane, Sheehama, Jacob A, Nepolo, Emmanuel, Günther, Gunar, Dockrell, Hazel M, Corstjens, Paul L A M, Stanley, Kim, Walzl, Gerhard, Chegou, Novel N

“…The development of a non-sputum-based, point-of-care diagnostic test for tuberculosis (TB) is a priority in the global effort to combat this disease,…”
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Treatment Outcomes in Multidrug-Resistant Tuberculosis by Günther, Gunar, Lange, Christoph, Alexandru, Sofia, Altet, Neus, Avsar, Korkut, Bang, Didi, Barbuta, Raisa, Bothamley, Graham, Ciobanu, Ana, Crudu, Valeriu, Danilovits, Manfred, Dedicoat, Martin, Duarte, Raquel, Gualano, Gina, Kunst, Heinke, de Lange, Wiel, Leimane, Vaira, Magis-Escurra, Cecile, McLaughlin, Anne-Marie, Muylle, Inge, Polcová, Veronika, Popa, Christina, Rumetshofer, Rudolf, Skrahina, Alena, Solodovnikova, Varvara, Spinu, Victor, Tiberi, Simon, Viiklepp, Piret, van Leth, Frank

“…Multidrug-resistant tuberculosis is a major global challenge. This report examines the definition of treatment success and its effect on determining cure. To…”
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Long‐term outcome following successful endoscopic closure of tracheo‐oesophageal fistulas with two cardiac amplatzer septal occluders in a patient with oesophageal cancer by Schreder, Theresa, Borbély, Yves, Christen, Stefan, Wiest, Reiner, Räber, Lorenz, Günther, Gunar

“…Acquired tracheo‐oesophageal fistulas (TEFs) are rare and challenging complications in the course of oesophageal cancer. While surgery is the only curative…”
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Availability, price and affordability of anti-tuberculosis drugs in Europe: a TBNET survey by Günther, Gunar, Gomez, Gabriela B, Lange, Christoph, Rupert, Stephan, van Leth, Frank

“…Data on availability and cost of anti-tuberculosis (TB) drugs in relation to affordability at national level are scarce. We performed a cross-sectional study…”
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Increased expression of beta-defensin 1 (DEFB1) in chronic obstructive pulmonary disease by Andresen, Ellen, Günther, Gunar, Bullwinkel, Jörn, Lange, Christoph, Heine, Holger

“…On-going airway inflammation is characteristic for the pathophysiology of chronic obstructive pulmonary disease (COPD). However, the key factors determining…”
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Implementation of targeted next-generation sequencing for the diagnosis of drug-resistant tuberculosis in low-resource settings: a programmatic model, challenges, and initial outcomes by de Araujo, Leonardo, Cabibbe, Andrea Maurizio, Mhuulu, Lusia, Ruswa, Nunurai, Dreyer, Viola, Diergaardt, Azaria, Günther, Gunar, Claassens, Mareli, Gerlach, Christiane, Utpatel, Christian, Cirillo, Daniela Maria, Nepolo, Emmanuel, Niemann, Stefan

“…Targeted next-generation sequencing (tNGS) from clinical specimens has the potential to become a comprehensive tool for routine drug-resistance (DR) prediction…”
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To treat or not to treat tuberculosis –clinical decision making in patients with previous pulmonary tuberculosis using 18F-FDG PET/CT by Günther, Gunar, Abu- Hussain, Nebal, Keller, Peter M., Guler, Reto, Mukasa, Sandra L., Wolmarans, Karen, Thienemann, Friedrich

“…Post-tuberculosis (TB) radiological changes and symptoms can mimic TB. PCR-based diagnostic tests can show positive results, suggesting the presence of…”
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Multidrug-resistant tuberculosis in Europe, 2010-2011 by Günther, Gunar, van Leth, Frank, Alexandru, Sofia, Altet, Neus, Avsar, Korkut, Bang, Didi, Barbuta, Raisa, Bothamley, Graham, Ciobanu, Ana, Crudu, Valeriu, Davilovits, Manfred, Dedicoat, Martin, Duarte, Raquel, Gualano, Gina, Kunst, Heinke, de Lange, Wiel, Leimane, Vaira, Magis-Escurra, Cecile, McLaughlin, Anne-Marie, Muylle, Inge, Polcová, Veronika, Pontali, Emanuele, Popa, Christina, Rumetshofer, Rudolf, Skrahina, Alena, Solodovnikova, Varvara, Spinu, Victor, Tiberi, Simon, Viiklepp, Piret, Lange, Christoph

“…Drug-resistant Mycobacterium tuberculosis is challenging elimination of tuberculosis (TB). We evaluated risk factors for TB and levels of second-line drug…”
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Enhanced active case finding of drug-resistant tuberculosis in Namibia: a protocol for the hotspots, hospitals, and households (H3TB) study by Shavuka, Olga, Iipumbu, Etuhole, Boois, Lorraine, Günther, Gunar, Hoddinott, Graeme, Lin, Hsien-Ho, Nepolo, Emmanuel, Niemann, Stefan, Ruswa, Nunurai, Seddon, James, Claassens, Mareli M

“…IntroductionNamibia is a high tuberculosis (TB)-burden country with an estimated incidence of 460/100 000 (around 12 000 cases) per year. Approximately 4.5% of…”
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Drug-Resistant Tuberculosis Case-Finding Strategies: Scoping Review by van Wyk, Susanna S, Nliwasa, Marriott, Lu, Fang-Wen, Lan, Chih-Chan, Seddon, James A, Hoddinott, Graeme, Viljoen, Lario, Günther, Gunar, Ruswa, Nunurai, Shah, N Sarita, Claassens, Mareli

“…Finding individuals with drug-resistant tuberculosis (DR-TB) is important to control the pandemic and improve patient clinical outcomes. To our knowledge,…”
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Tuberculosis Treatment Outcomes in Europe: Based on Treatment Completion, Not Cure by Dedicoat, Martin J, Günther, Gunar, Crudu, Valeriu, Duarte, Raquel, Gualano, Gina, Magis-Escurra, Cecile, Rumetshofer, Rudolf, Skrahina, Alena, Spinu, Victor, Tiberi, Simon, Viiklepp, Piret, van Leth, Frank, Lange, Christoph

“…According to the World Health Organization (WHO), successful treatment outcome from pulmonary TB includes patients who meet the criteria for cure and treatment…”
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Diffuse pulmonary small nodular and patchy infiltrates on chest X-ray with hemoptysis: TB or not TB?-a call for scale up of respiratory medicine services in African TB high burden countries: a case of idiopathic pulmonary hemosiderosis by de Klerk, Kerclin Danielle, Bau, Steffen, Günther, Gunar

“…Tuberculosis is still one of the most common respiratory diseases in Africa and worldwide and miliary tuberculosis is a regular manifestation of it. Idiopathic…”
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Protocol for systematic review and meta-analysis: impact of statins as immune-modulatory agents on inflammatory markers in adults with chronic diseases by Sabeel, Solima, Motaung, Bongani, Ozturk, Mumin, Mukasa, Sandra, Kengne, Andre Pascal, Blom, Dirk, Sliwa, Karen, Nepolo, Emmanuel, Günther, Gunar, Wilkinson, Robert J., Schacht, Claudia, Thienemann, Friedrich, Guler, Reto

“…IntroductionStatins, also known as 3-hydroxy-3-methylglutaryl coenzyme-A (HMG-CoA) reductase inhibitors, are lipid-lowering agents that are central in…”
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Case-Finding Strategies for Drug-Resistant Tuberculosis: Protocol for a Scoping Review by Van Wyk, Susanna S, Nliwasa, Marriott, Seddon, James A, Hoddinott, Graeme, Viljoen, Lario, Nepolo, Emmanuel, Günther, Gunar, Ruswa, Nunurai, Lin, Hsien-Ho, Niemann, Stefan, Gandhi, Neel R, Shah, N Sarita, Claassens, Mareli

“…Transmission of drug-resistant tuberculosis (DR-TB) is ongoing. Finding individuals with DR-TB and initiating treatment as early as possible is important to…”
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