In vitro susceptibility of methicillin-resistant Staphylococcus aureus isolates to vancomycin, teicoplanin, linezolide and daptomycin

In this study, vancomycin, teicoplanin, linezolide and daptomycin susceptibility rates of 67 methicillin-resistant Staphylococcus aureus (MRSA) isolates obtained from various clinical samples between November 2006 and August 2010 in our laboratories, were investigated by E-test method and MIC values...

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Bibliographic Details
Published in:	Mikrobiyoloji bülteni Vol. 45; no. 3; pp. 512 - 518
Main Authors:	Celikbilek, Nevreste, Ozdem, Birsen, Gürelik, Feryal C, Güvenman, Selda, Güner, H Rahmet, Açıkgöz, Ziya Cibali
Format:	Journal Article
Language:	Turkish
Published:	Turkey 01-07-2011
Subjects:	Acetamides - pharmacology Anti-Bacterial Agents - pharmacology Daptomycin - pharmacology Female Humans Linezolid Male Methicillin-Resistant Staphylococcus aureus - drug effects Microbial Sensitivity Tests Oxazolidinones - pharmacology Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Teicoplanin - pharmacology Vancomycin - pharmacology
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Summary:	In this study, vancomycin, teicoplanin, linezolide and daptomycin susceptibility rates of 67 methicillin-resistant Staphylococcus aureus (MRSA) isolates obtained from various clinical samples between November 2006 and August 2010 in our laboratories, were investigated by E-test method and MIC values of the drugs were determined. Seventeen (25%) of the samples were from outpatient wards, 50 (75%) from inpatients of which 24 (48%) were from intensive care units. Distribution of MRSA isolated clinical samples were as follows: 16 (23.4%) blood, 28 (42.2%) wound swab, 15 (21.8%) tracheal aspirate, 2 (3.1%) urine, 2 (3.1%) urethral discharge, and one for each (1.6%) cerebrospinal fluid, joint fluid, catheter tip and nasal swab. Except one (1.5%) which was probably intermediate-resistant to vancomycin (since not confirmed by microdilution test or population analysis, this isolate was considered as "probable" intermediate-resistant), all of the isolates were found susceptible to all tested antibiotics. MIC(50) and MIC(90) values were determined as 0.75 and 1.5 µg/ml for vancomycin, 2 and 3 µg/ml for teicoplanin, 0.38 and 0.5 µg/ml for linezolide and 0.094 and 0.19 µg/ml for daptomycin, respectively. The MIC ranges were 0.25-3 µg/ml for vancomycin, 0.125-4 µg/ml for teicoplanin, 0.094-3 µg/ml for linezolide and 0.047-0.25 µg/ml for daptomycin. There was no statistically significant difference between MICs of outpatient, inpatient and intensive care unit isolates for any of the tested drugs (p> 0.05). Based on MIC90 values, daptomycin seems 4-16 times more effective than the other three drugs. It was concluded that considering their in-vitro antibacterial activity, these antibiotics can be used as alternatives to each other for the treatment of MRSA infections.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0374-9096