Search Results - "Güler,Günnur"

Biomolecular fingerprints of the effect of zoledronic acid on prostate cancer stem cells: Comparison of 2D and 3D cell culture models by Güler, Günnur, Acikgoz, Eda, Mukhtarova, Günel, Oktem, Gulperi

“…Revealing the potential of candidate drugs against different cancer types without disrupting normal cells depends on the drug mode of action. In the current…”
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Glycogen synthase kinase-3 inhibition in glioblastoma multiforme cells induces apoptosis, cell cycle arrest and changing biomolecular structure by Acikgoz, Eda, Güler, Günnur, Camlar, Mahmut, Oktem, Gulperi, Aktug, Huseyin

“…Glioblastoma multiforme (GBM) is the most malignant and aggressive primary human brain tumors. The regulatory pathways of apoptosis are altered in GBMs,…”
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Coronavirus disease 2019 (COVID-19): Biophysical and biochemical aspects of SARS-CoV-2 and general characteristics by Güler, Günnur, Özdemir, Helin, Omar, Dilara, Akdoğan, Gül

“…The coronavirus disease (COVID-19) arises from the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) which is an enveloped RNA virus. COVID-19 has…”
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Synthesis and characterization of folic acid-chitosan nanoparticles loaded with thymoquinone to target ovarian cancer cells by İnce, İskender, Yıldırım, Yeliz, Güler, Günnur, Medine, Emin İlker, Ballıca, Gülşah, Kuşdemir, Bekir Cem, Göker, Erdem

“…The aim of the present research was to formulate and characterize radioiodinated folic acid-chitosan conjugated thymoquinone nanoparticles (FATQCSNPs) and to…”
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The effect of extracellular matrix on the differentiation of mouse embryonic stem cells by Ozdil, Berrin, Güler, Günnur, Acikgoz, Eda, Kocaturk, Duygu Calik, Aktug, Huseyin

“…Embryonic stem cells (ESCs) are promising research materials to investigate cell fate determination since they have the capability to differentiate. Stem cell…”
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Caffeic acid phenethyl ester (CAPE) Chitosan capped ZnO nanoparticles: Preparation, characterization, and its potential for the treatment of prostate cancer by İnce, İskender, Yıldırım, Yeliz, Göker, Erdem, Güler, Günnur, Saltan, Fehmi, Acar, Rıza, Gümüştaş, Barış, Medine, E. İlker

“…•Caffeic acid phenethyl ester (CAPE) loaded Zinc oxide nanoparticles/Chitosan (ZnONPs/CS) formulation was prepared.•The prostate cancer treatment effectiveness…”
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Proteolysis of Micellar β-Casein by Trypsin: Secondary Structure Characterization and Kinetic Modeling at Different Enzyme Concentrations by Vorob'ev, Mikhail M, Açıkgöz, Burçin Dersu, Güler, Günnur, Golovanov, Andrey V, Sinitsyna, Olga V

“…Tryptic proteolysis of protein micelles was studied using β-casein (β-CN) as an example. Hydrolysis of specific peptide bonds in β-CN leads to the degradation…”
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Deciphering the biochemical similarities and differences among mouse embryonic stem cells, somatic and cancer cells using ATR-FTIR spectroscopy by Güler, Günnur, Acikgoz, Eda, Karabay Yavasoglu, N Ülkü, Bakan, Buket, Goormaghtigh, Erik, Aktug, Huseyin

“…Cellular macromolecules play important roles in cellular behaviors and biological processes. In the current work, cancer (KLN205), normal (MSFs) and mouse…”
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Effect of Flavopiridol on Cell Cycle, Apoptosis and Biomolecule Structure Changes in Breast Cancer Stem Cells by AÇIKGÖZ, Eda, GÜLER, Günnur, ÖKTEM, Gülperi

“…Objective: Cancer stem cells (CSCs) are a small population in cancer, which are responsible for therapeutic resistance, relapse and metastasis. Flavopiridol…”
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A Soluble Fragment of the Tumor Antigen BCL2-associated Athanogene 6 (BAG-6) Is Essential and Sufficient for Inhibition of NKp30 Receptor-dependent Cytotoxicity of Natural Killer Cells by Binici, Janina, Hartmann, Jessica, Herrmann, Julia, Schreiber, Christine, Beyer, Steffen, Güler, Günnur, Vogel, Vitali, Tumulka, Franz, Abele, Rupert, Mäntele, Werner, Koch, Joachim

“…Immunosurveillance of tumor cells depends on NKp30, a major activating receptor of human natural killer (NK) cells. The human BCL2-associated athanogene 6…”
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Spectroscopic and Computational Molecular Docking studies on the protein-drug interactions by Cinar, Iraz, Aksoy, Irem, Guler, Gunnur

“…Investigation of the protein-drug active substance interactions has great importance in the fields of medicine, chemistry, pharmaceutical, biomedical and…”
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Proteolytically-induced changes of secondary structural protein conformation of bovine serum albumin monitored by Fourier transform infrared (FT-IR) and UV-circular dichroism spectroscopy by Güler, Günnur, Vorob'ev, Mikhail M., Vogel, Vitali, Mäntele, Werner

“…Enzymatically-induced degradation of bovine serum albumin (BSA) by serine proteases (trypsin and α-chymotrypsin) in various concentrations was monitored by…”
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Flow Cytometry and FTIR Spectroscopy for Detection of Early Apoptosis in Human T Cells by Günnur Güler, Ayten Nalbant

“…Apoptosis, a programmed cell death, has a vital role in various cellular processes. Apoptotic cells exhibit morphological and biochemical changes, detected by…”
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Lipid-Protein Interactions in the Regulated Betaine Symporter BetP Probed by Infrared Spectroscopy by Güler, Günnur, Gärtner, Rebecca M., Ziegler, Christine, Mäntele, Werner

“…The Na+-coupled betaine symporter BetP senses changes in the membrane state and increasing levels of cytoplasmic K+ during hyperosmotic stress latter via its…”
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An Investigation of RNA Methylations with Biophysical Approaches in a Cervical Cancer Cell Model by Sağlam, Buket, Akkuş, Onur, Akçaöz-Alasar, Azime, Ceylan, Çağatay, Güler, Günnur, Akgül, Bünyamin

“…RNA methylation adds a second layer of genetic information that dictates the post-transcriptional fate of RNAs. Although various methods exist that enable the…”
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IR spektroskopi kullanılarak in vitro meme kanser kök hücrelerinin araştırılması by GÜLER, Günnur, GÜVEN, Ümmü, AÇIKGÖZ, Eda, ÖKTEM, Gülperi

“…Amaç: Kanser kök hücreleri (KKH), tümör içinde kendi kendilerini yenileme ve diğer hücre tiplerine farklılaşabilme kapasitesi sebebiyle tümörün başlaması,…”
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Real time observation of proteolysis with Fourier transform infrared (FT-IR) and UV-circular dichroism spectroscopy: Watching a protease eat a protein by Güler, Günnur, Džafić, Enela, Vorob’ev, Mikhail M., Vogel, Vitali, Mäntele, Werner

“…[Display omitted] ► β-LG and β-CN were digested by trypsin using FT-IR- and UV-CD spectroscopes.► Substrates were converted into the peptide fragments upon…”
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Fourier dönüşümü kızılötesi spektroskopisi ile CD133+/CD44+ prostat kanser kök hücrelerinin iki boyutlu ve üç boyutlu ortamdaki hücresel farklılıklarının belirlemesi by Güler,Günnur, Açıkgöz,Eda, Öktem,Gülperi

“…Amaç: Sferoid kültürleri, hücrelerin kendi iç dinamikleri ve diğer hücrelerle olan etkileşimleri açısından tek tabakalı kültürlere kıyasla tümör dokusunun…”
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Monitoring of Demasking of Peptide Bonds During Proteolysis by Analysis of the Apparent Spectral Shift of Intrinsic Protein Fluorescence by Vorob’ev, Mikhail M., Vogel, Vitali, Güler, Günnur, Mäntele, Werner

“…Demasking of peptide bonds during proteolysis of β-casein and β-lactoglobulin by trypsin was monitored by the measurement of the overall spectral shift of…”
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A novel method for sensitive microRNA detection: Electropolymerization based doping by Kaplan, Merve, Kilic, Tugba, Guler, Gunnur, Mandli, Jihane, Amine, Aziz, Ozsoz, Mehmet

“…In the proposed study, for the first time, sensitive electrochemical detection of a breast cancer biomarker microRNA (miRNA), mir-21 was achieved via…”
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