TTF-1 and surfactant-B as co-adjuvants in the diagnosis of lung adenocarcinoma and pleural mesothelioma

Primary lung adenocarcinomas and metastatic adenocarcinomas may show a great morphologic resemblance to malignant mesothelioma. There are numerous immunohistochemical markers being used, but none of them were proved to be effective enough to reach a certain diagnosis. The current study was performed...

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Bibliographic Details
Published in:	Annals of diagnostic pathology Vol. 8; no. 6; pp. 337 - 341
Main Authors:	Bakir, Kemal, Koçer, N.Emrah, Deniz, Hale, Güldür, M.Emin
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-12-2004
Subjects:	Adenocarcinoma Adenocarcinoma - diagnosis Adenocarcinoma - metabolism Biomarkers, Tumor - metabolism Diagnosis, Differential Humans Lung Neoplasms - diagnosis Lung Neoplasms - metabolism Mesothelioma - diagnosis Mesothelioma - metabolism Nuclear Proteins - metabolism pleural mesothelioma Pleural Neoplasms - diagnosis Pleural Neoplasms - metabolism Pulmonary Surfactant-Associated Protein B - metabolism Reproducibility of Results Retrospective Studies surfactant-B Thyroid Nuclear Factor 1 thyroid transcription factor-1 (TTF-1) Transcription Factors - metabolism Adenocarcinoma thyroid transcription factor-1 (TTF-1) surfactant-B pleural mesothelioma
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Summary:	Primary lung adenocarcinomas and metastatic adenocarcinomas may show a great morphologic resemblance to malignant mesothelioma. There are numerous immunohistochemical markers being used, but none of them were proved to be effective enough to reach a certain diagnosis. The current study was performed to evaluate the utility of thyroid transcription factor-1 (TTF-1) and surfactant protein-B (SP-B) expression in the differential diagnosis between lung adenocarcinomas and pleural mesotheliomas. In this retrospective study, TTF-1 and SP-B were applied to 30 cases with adenocarcinoma and 15 cases with pleural mesothelioma, immunohistochemically, using an avidin-biotin detection system. Twenty percent of adenocarcinomas and 13.3% of pleural mesothelioma stained positive for SP-B. TTF-1 stained 24 of the 30 adenocarcinomas (80%) and none of the 15 mesotheliomas (0%). TTF-1 positivity in adenocarcinomas was found to be statistically significant, while SP-B had no important practical value either used alone or in combination with TTF-1. There was no statistically significant correlation between the differentiation level of adenocarcinomas and TTF-1 staining pattern. In conclusion, we believe that TTF-1 may be helpful in distinguishing lung adenocarcinoma from pleural mesothelioma.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1092-9134 1532-8198
DOI:	10.1053/j.anndiagpath.2004.08.003