Search Results - "Götze, K S"

Blockade of BCL-2 proteins efficiently induces apoptosis in progenitor cells of high-risk myelodysplastic syndromes patients by Jilg, S, Reidel, V, Müller-Thomas, C, König, J, Schauwecker, J, Höckendorf, U, Huberle, C, Gorka, O, Schmidt, B, Burgkart, R, Ruland, J, Kolb, H-J, Peschel, C, Oostendorp, R A J, Götze, K S, Jost, P J

“…Deregulated apoptosis is an identifying feature of myelodysplastic syndromes (MDS). Whereas apoptosis is increased in the bone marrow (BM) of low-risk MDS…”
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The new WHO 2022 and ICC proposals for the classification of myelodysplastic neoplasms. Validation based on the Düsseldorf MDS Registry and proposals for a merged classification by Nachtkamp, K., Strupp, C., Vukelja, M., Kasprzak, A., Haase, D., Ganster, C., Hildebrandt, B., Betz, B., Giagounidis, A., Aul, C., Blum, S., Hofmann, W. K., Pfeilstöcker, M., Valent, P., Lübbert, M., Seidl, M., Rudelius, M., Stauder, R., Krieger, O., Götze, K. S., Bobak, J., Kündgen, A., Schulz, F., Dietrich, S., Kobbe, G., Gattermann, N., Germing, U.

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Efficacy and safety of bemcentinib in patients with advanced myelodysplastic neoplasms or acute myeloid leukemia failing hypomethylating agents- the EMSCO phase II BERGAMO trial by Kubasch, A. S., Peterlin, P., Cluzeau, T., Götze, K. S., Sockel, K., Teipel, R., Jentzsch, M., Attalah, H., Sebert, M., Chermat, F., Gloaguen, S., Puttrich, M., Cross, M., Schneider, M., Kayser, S., Schipp, D., Giagounidis, A., Tirado-Gonzalez, I., Descot, A., van de Loosdrecht, A., Weigert, A., Metzeler, K. H., Fenaux, P., Medyouf, H., Platzbecker, U., Ades, L.

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Effects of imatinib on bone marrow engraftment in syngeneic mice by HOEPFL, J, MIETHING, C, GRUNDLER, R, GÖTZE, K. S, PESCHEL, C, DUYSTER, J

“…Chronic myeloid leukemia (CML) and a subset of acute lymphoblastic leukemias arise from the genetic reciprocal translocation t(9;22), forming the BCR-ABL…”
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Murine stromal cells producing hyper-interleukin-6 and Flt3 ligand support expansion of early human hematopoietic progenitor cells without need of exogenous growth factors by KELLER, U, GÖTZE, K. S, DUYSTER, J, SCHMIDT, B, ROSE-JOHN, S, PESCHEL, C

“…Expansion of primitive hematopoietic progenitor cells (HPC) is a major challenge in stem cell biology. Stimulation by growth factors (GF) is essential for…”
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S169: CLINICAL AND MOLECULAR MARKERS FOR PREDICTING RESPONSE TO ROMIPLOSTIM TREATMENT IN LOWER‐RISK MYELODYSPLASTIC SYNDROMES by Kubasch, A. S., Giagounidis, A., Metzgeroth, G., Jonasova, A., Herbst, R., Diaz, J. M. T., De Renzis, B., Götze, K. S., Huetter‐Kroenke, M.‐L., Gourin, M.‐P., Slama, B., Dimicoli‐Salazar, S., Cony‐Makhoul, P., Laribi, K., Park, S., Jersemann, K., Schipp, D., Metzeler, K. H., Tiebel, O., Sockel, K., Gloaguen, S., Mies, A., Chermat, F., Thiede, C., Sapena, R., Schlenk, R. F., Fenaux, P., Platzbecker, U., Ades, L.

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The role of azacitidine in the management of myelodysplastic syndromes (MDS) by Götze, Ks, Müller-Thomas, C, Peschel, C

“…Myelodysplastic syndromes (MDS) are a group of common bone marrow disorders characterized by ineffective hematopoiesis, peripheral cytopenias, and a propensity…”
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Flt3high and Flt3low CD34+ progenitor cells isolated from human bone marrow are functionally distinct by GÖTZE, K. S, RAMIREZ, M, TABOR, K, SMALL, D, MATTHEWS, W, CIVIN, C. I

“…We generated monoclonal antibodies against the human Flt3 receptor and used them to study the characteristics of normal human bone marrow cells resolved based…”
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Human herpes virus 8 interleukin‐6 homologue triggers gp130 on neuronal and hematopoietic cells by Hoischen, Susanne H., Vollmer, Petra, März, Pia, Özbek, Suat, Götze, Katharina S., Peschel, Christian, Jostock, Thomas, Geib, Till, Müllberg, Jürgen, Mechtersheimer, Sabine, Fischer, Martina, Grötzinger, Joachim, Galle, Peter R., Rose‐John, Stefan

“…Human herpes virus‐8 (HHV8) encodes a cytokine named viral interleukin‐6 (vIL‐6) that shares 25% amino‐acid identity with its human homologue. Human IL‐6 is…”
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gp130-Stimulating designer cytokine Hyper-interleukin-6 synergizes with murine stroma for long-term survival of primitive human hematopoietic progenitor cells by Götze, Katharina S, Keller, Ulrich, Rose-John, Stefan, Peschel, Christian

“…Experimental strategies for ex vivo expansion of human hematopoietic stem/progenitor cells involve the use of exogenous cytokines as well as direct interaction…”
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Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes by Fenaux, Pierre, Platzbecker, Uwe, Mufti, Ghulam J, Garcia-Manero, Guillermo, Buckstein, Rena, Santini, Valeria, Díez-Campelo, María, Finelli, Carlo, Cazzola, Mario, Ilhan, Osman, Sekeres, Mikkael A, Falantes, José F, Arrizabalaga, Beatriz, Salvi, Flavia, Giai, Valentina, Vyas, Paresh, Bowen, David, Selleslag, Dominik, DeZern, Amy E, Jurcic, Joseph G, Germing, Ulrich, Götze, Katharina S, Quesnel, Bruno, Beyne-Rauzy, Odile, Cluzeau, Thomas, Voso, Maria-Teresa, Mazure, Dominiek, Vellenga, Edo, Greenberg, Peter L, Hellström-Lindberg, Eva, Zeidan, Amer M, Adès, Lionel, Verma, Amit, Savona, Michael R, Laadem, Abderrahmane, Benzohra, Aziz, Zhang, Jennie, Rampersad, Anita, Dunshee, Diana R, Linde, Peter G, Sherman, Matthew L, Komrokji, Rami S, List, Alan F

“…Luspatercept is a fusion protein aimed at binding TGF-β family members and reducing SMAD2 and SMAD3 signaling in patients with myelodysplasia with ring…”
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Imatinib and leptomycin B are effective in overcoming imatinib-resistance due to Bcr-Abl amplification and clonal evolution but not due to Bcr-Abl kinase domain mutation by Kancha, Rama Krishna, von Bubnoff, Nikolas, Miething, Cornelius, Peschel, Christian, Gotze, Katharina S, Duyster, Justus

“…Department of Internal Medicine III, Klinikum rechts der Isar, Technical University of Munich, Germany Correspondence: Justus Duyster, Dept. of Internal…”
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The Medalist Trial: Results of a Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Luspatercept to Treat Anemia in Patients with Very Low-, Low-, or Intermediate-Risk Myelodysplastic Syndromes (MDS) with Ring Sideroblasts (RS) Who Require Red Blood Cell (RBC) Transfusions by Fenaux, Pierre, Platzbecker, Uwe, Mufti, Ghulam J., Garcia-Manero, Guillermo, Buckstein, Rena, Santini, Valeria, Díez-Campelo, María, Finelli, Carlo, Cazzola, Mario, Ilhan, Osman, Sekeres, Mikkael A., Falantes, José F., Arrizabalaga, Beatriz, Salvi, Flavia, Giai, Valentina, Vyas, Paresh, Bowen, David, Selleslag, Dominik, DeZern, Amy E., Jurcic, Joseph G., Germing, Ulrich, Götze, Katharina S., Quesnel, Bruno, Beyne-Rauzy, Odile, Cluzeau, Thomas, Voso, Maria Teresa, Mazure, Dominiek, Vellenga, Edo, Greenberg, Peter L, Hellström-Lindberg, Eva, Zeidan, Amer M., Laadem, Abderrahmane, Benzohra, Aziz, Zhang, Jennie, Rampersad, Anita, Linde, Peter G., Sherman, Matthew L., Komrokji, Rami S., List, Alan F.

“…▪ Introduction: MDS is associated with an erythroid maturation defect, characterized by ineffective erythropoiesis leading to anemia and RBC transfusion…”
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Progressive disruption of hematopoietic architecture from clonal hematopoiesis to MDS by Buck, Michèle C., Bast, Lisa, Hecker, Judith S., Rivière, Jennifer, Rothenberg-Thurley, Maja, Vogel, Luisa, Wang, Dantong, Andrä, Immanuel, Theis, Fabian J., Bassermann, Florian, Metzeler, Klaus H., Oostendorp, Robert A.J., Marr, Carsten, Götze, Katharina S.

“…Clonal hematopoiesis of indeterminate potential (CHIP) describes the age-related acquisition of somatic mutations in hematopoietic stem/progenitor cells (HSPC)…”
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Fatal Epstein-Barr virus-associated lymphoproliferative disorder following treatment with a novel mTOR Inhibitor for relapsed chronic lymphocytic leukemia by Gotze, Katharina S, Hoffmann, Dieter, Schatzl, Hermann M, Peschel, Christian, Fend, Falko, Decker, Thomas

“…* III. Department of Medicine, ° Institute of Virology # Institute for Pathology, Technical University of Munich, Munich, Germany Correspondence: Katharina S…”
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Polycomb protein RING1A limits hematopoietic differentiation in myelodysplastic syndromes by Palau, Anna, Garz, Anne-Kathrin, Diesch, Jeannine, Zwick, Anabel, Malinverni, Roberto, Valero, Vanesa, Lappin, Katrina, Casquero, Raquel, Lennartsson, Andreas, Zuber, Johannes, Navarro, Tomàs, Mills, Ken I, Götze, Katharina S, Buschbeck, Marcus

“…Genetic lesions affecting epigenetic regulators are frequent in myelodysplastic syndromes (MDS). Polycomb proteins are key epigenetic regulators of…”
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Computational modeling of stem and progenitor cell kinetics identifies plausible hematopoietic lineage hierarchies by Bast, Lisa, Buck, Michèle C., Hecker, Judith S., Oostendorp, Robert A.J., Götze, Katharina S., Marr, Carsten

“…Classically, hematopoietic stem cell (HSC) differentiation is assumed to occur via progenitor compartments of decreasing plasticity and increasing maturity in…”
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Endothelial-like cells expanded from CD34⁺ blood cells improve left ventricular function after experimental myocardial infarction by Ott, Ilka, Keller, Ulrich, Knoedler, Martina, Götze, Katharina S, Doss, Katharina, Fischer, Philipp, Urlbauer, Katja, Debus, Gerlinde, von Bubnoff, Nikolas, Rudelius, Martina, Schömig, Albert, Peschel, Christian, Oostendorp, Robert A. J

“…ABSTRACTMobilization and recruitment of endothelial progenitor cells (EPC) contributes to vasculogenesis in vivo. So far, applications for cell therapy are…”
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