Search Results - "Göpel, Sven"

Stearoyl CoA desaturase is a gatekeeper that protects human beta cells against lipotoxicity and maintains their identity by Oshima, Masaya, Pechberty, Séverine, Bellini, Lara, Göpel, Sven O., Campana, Mélanie, Rouch, Claude, Dairou, Julien, Cosentino, Cristina, Fantuzzi, Federica, Toivonen, Sanna, Marchetti, Piero, Magnan, Christophe, Cnop, Miriam, Le Stunff, Hervé, Scharfmann, Raphaël

“…Aims/hypothesis During the onset of type 2 diabetes, excessive dietary intake of saturated NEFA and fructose lead to impaired insulin production and secretion…”
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SGLT2 inhibition with empagliflozin improves coronary microvascular function and cardiac contractility in prediabetic ob/ob -/- mice by Adingupu, Damilola D, Göpel, Sven O, Grönros, Julia, Behrendt, Margareta, Sotak, Matus, Miliotis, Tasso, Dahlqvist, Ulrika, Gan, Li-Ming, Jönsson-Rylander, Ann-Cathrine

“…Sodium-glucose cotransporter 2 inhibitors (SGLT2i) is the first class of anti-diabetes treatment that reduces mortality and risk for hospitalization due to…”
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Dapagliflozin stimulates glucagon secretion at high glucose: experiments and mathematical simulations of human A-cells by Pedersen, Morten Gram, Ahlstedt, Ingela, El Hachmane, Mickaël F., Göpel, Sven O.

“…Glucagon is one of the main regulators of blood glucose levels and dysfunctional stimulus secretion coupling in pancreatic A-cells is believed to be an…”
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Glial cell-line derived neurotrophic factor protects human islets from nutrient deprivation and endoplasmic reticulum stress induced apoptosis by Abadpour, Shadab, Göpel, Sven O., Schive, Simen W., Korsgren, Olle, Foss, Aksel, Scholz, Hanne

“…One of the key limitations to successful human islet transplantation is loss of islets due to stress responses pre- and post-transplantation. Nutrient…”
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SGLT2 inhibition improves coronary flow velocity reserve and contractility: role of glucagon signaling by Göpel, Sven O., Adingupu, Damilola, Wang, Jue, Semenova, Elizaveta, Behrendt, Margareta, Jansson-Löfmark, Rasmus, Ahlström, Christine, Jönsson-Rylander, Ann-Cathrine, Gopaul, V. Sashi, Esterline, Russell, Gan, Li-Ming, Xiao, Rui-Ping

“…Abstract Background SGLT2 inhibitors, a T2DM medication to lower blood glucose, markedly improve cardiovascular outcomes but the underlying mechanism(s) are…”
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High throughput generation of a resource of the human secretome in mammalian cells by Tegel, Hanna, Dannemeyer, Melanie, Kanje, Sara, Sivertsson, Åsa, Berling, Anna, Svensson, Anne-Sophie, Hober, Andreas, Enstedt, Henric, Volk, Anna-Luisa, Lundqvist, Magnus, Moradi, Mona, Afshari, Delaram, Ekblad, Siri, Xu, LanLan, Westin, Malin, Bidad, Faranak, Schiavone, Lovisa Holmberg, Davies, Rick, Mayr, Lorenz M., Knight, Sinead, Göpel, Sven O., Voldborg, Björn G., Edfors, Fredrik, Forsström, Björn, von Feilitzen, Kalle, Zwahlen, Martin, Rockberg, Johan, Takanen, Jenny Ottosson, Uhlén, Mathias, Hober, Sophia

“…•A high-throughput pipeline for production of the human secretome in mammalian cells has been set up.•Almost 1,300 proteins have successfully been produced and…”
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Cell coupling in mouse pancreatic β-cells measured in intact islets of Langerhans by Zhang, Quan, Galvanovskis, Juris, Abdulkader, Fernando, Partridge, Christopher J, Göpel, Sven O, Eliasson, Lena, Rorsman, Patrik

“…waves to spread with a speed of approximately 80 μm s…”
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Hyperglucagonemia in youth is associated with high plasma free fatty acids, visceral adiposity, and impaired glucose tolerance by Manell, Hannes, Kristinsson, Hjalti, Kullberg, Joel, Ubhayasekera, Sarojini Jayantha Kumari, Mörwald, Katharina, Staaf, Johan, Cadamuro, Janne, Zsoldos, Fanni, Göpel, Sven, Sargsyan, Ernest, Ahlström, Håkan, Bergquist, Jonas, Weghuber, Daniel, Forslund, Anders, Bergsten, Peter

“…Objective To delineate potential mechanisms for fasting hyperglucagonemia in childhood obesity by studying the associations between fasting plasma glucagon…”
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Palmitate Stimulation of Glucagon Secretion in Mouse Pancreatic α-Cells Results From Activation of l-Type Calcium Channels and Elevation of Cytoplasmic Calcium by OLOFSSON, Charlotta S, SALEHI, Albert, GÖPEL, Sven O, HOLM, Cecilia, RORSMAN, Patrik

“…Palmitate Stimulation of Glucagon Secretion in Mouse Pancreatic α-Cells Results From Activation of l -Type Calcium Channels and Elevation of Cytoplasmic…”
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Fast insulin secretion reflects exocytosis of docked granules in mouse pancreatic B-cells by Olofsson, Charlotta S, Göpel, Sven O, Barg, Sebastian, Galvanovskis, Juris, Ma, Xiaosong, Salehi, Albert, Rorsman, Patrik, Eliasson, Lena

“…A readily releasable pool (RRP) of granules has been proposed to underlie the first phase of insulin secretion. In the present study we combined electron…”
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Minimized cell usage for stem cell-derived and primary cells on an automated patch clamp system by Becker, Nadine, Stoelzle, Sonja, Göpel, Sven, Guinot, David, Mumm, Patrick, Haarmann, Claudia, Malan, Daniela, Bohlen, Heribert, Kossolov, Eugen, Kettenhofen, Ralf, George, Michael, Fertig, Niels, Brüggemann, Andrea

“…Chip-based automated patch clamp systems are widely used in drug development and safety pharmacology, allowing for high quality, high throughput screening at…”
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The Cell Physiology of Biphasic Insulin Secretion by Rorsman, Patrik, Eliasson, Lena, Renstrom, Erik, Gromada, Jesper, Barg, Sebastian, Gopel, Sven

“…Patrik Rorsman , Lena Eliasson , Erik Renström , Jesper Gromada , Sebastian Barg and Sven Göpel P. Rorsman, L. Elaisson, E. Renström, S. Barg, and S. Göpel are…”
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R-type Ca2+-channel-evoked CICR regulates glucose-induced somatostatin secretion by Zhang, Quan, Bengtsson, Martin, Partridge, Chris, Salehi, Albert, Braun, Matthias, Cox, Roger, Eliasson, Lena, Johnson, Paul RV, Renström, Erik, Schneider, Toni, Berggren, Per-Olof, Göpel, Sven, Ashcroft, Frances M, Rorsman, Patrik

“…Pancreatic islets have a central role in blood glucose homeostasis. In addition to insulin-producing beta-cells and glucagon-secreting alpha-cells, the islets…”
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The small molecule SERCA activator CDN1163 increases energy metabolism in human skeletal muscle cells by Mengeste, Abel M., Lund, Jenny, Katare, Parmeshwar, Ghobadi, Roya, Bakke, Hege G., Lunde, Per Kristian, Eide, Lars, Mahony, Gavin O’, Göpel, Sven, Peng, Xiao-Rong, Kase, Eili Tranheim, Thoresen, G. Hege, Rustan, Arild C.

“…A number of studies have highlighted muscle-specific mechanisms of thermogenesis involving futile cycling of Ca2+ driven by sarco (endo)plasmic reticulum…”
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Fast exocytosis with few Ca(2+) channels in insulin-secreting mouse pancreatic B cells by Barg, S, Ma, X, Eliasson, L, Galvanovskis, J, Göpel, S O, Obermüller, S, Platzer, J, Renström, E, Trus, M, Atlas, D, Striessnig, J, Rorsman, P

“…The association of L-type Ca(2+) channels to the secretory granules and its functional significance to secretion was investigated in mouse pancreatic B cells…”
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Cellular function in multicellular system for hormone-secretion: electrophysiological aspect of studies on α-, β- and δ-cells of the pancreatic islet by Kanno, Takahiro, Göpel, Sven O, Rorsman, Patrik, Wakui, Makoto

“…We review a new method to explore the cellular functions in multicellular system by application of the perforated patch-clamp technique to intact pancreatic…”
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Modelling the Electrical Activity of Pancreatic α-cells Based on Experimental Data from Intact Mouse Islets by Diderichsen, Paul M, Göpel, Sven O

“…Detailed experimental data from patch clamp experiments on pancreatic α-cells in intact mouse islets are used to model the electrical activity associated with…”
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Activation of Ca(2+)-dependent K(+) channels contributes to rhythmic firing of action potentials in mouse pancreatic beta cells by Göpel, S O, Kanno, T, Barg, S, Eliasson, L, Galvanovskis, J, Renström, E, Rorsman, P

“…We have applied the perforated patch whole-cell technique to beta cells within intact pancreatic islets to identify the current underlying the glucose-induced…”
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CaM kinase II-dependent mobilization of secretory granules underlies acetylcholine-induced stimulation of exocytosis in mouse pancreatic B-cells by Gromada, J, Høy, M, Renström, E, Bokvist, K, Eliasson, L, Göpel, S, Rorsman, P

“…Measurements of cell capacitance were used to investigate the mechanisms by which acetylcholine (ACh) stimulates Ca 2+ -induced exocytosis in single…”
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Mathematical Modeling of Human Pancreatic Alpha-Cells: Insight into the Role of SGLT2 in Glucagon Secretion by Pedersen, Morten G., Ahlstedt, Ingela, Andersson, Eva-Marie, Göpel, Sven

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