Interleukin (IL)-12, IL-2, interferon-γ gene polymorphisms in subacute sclerosing panencephalitis patients

Interleukin (IL)-12, IL-2, interferon-γ gene polymorphisms in subacute sclerosing panencephalitis patients

Mutated measles virus variants have been claimed as the causing agent for subacute sclerosing panencephalitis (SSPE) developing several years after the recovery from measles infection. However, immune dysfunction may be considered related to a genetic susceptibility to this rare disease. Interleukin...

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Bibliographic Details
Published in:Journal of neurovirology Vol. 13; no. 5; pp. 410 - 415
Main Authors: Y lmaz, Vuslat, Demirbilek, Veysi, Gürses, Candan, Yentür, Sibel P, Uysal, Serap, Yap c, Zuhal, Y lmaz, Gülden, Muncey, Aaron, Çokar, Özlem, Önal, Emel, Gökyi it, Ay en, Saruhan-Direskeneli, Güher
Format: Journal Article
Language:English
Published: London Informa UK Ltd 01-10-2007
Taylor & Francis
Subjects:
Biological and medical sciences
DNA Primers
Human viral diseases
Humans
Immunomodulators
Infectious diseases
Interferon-gamma - genetics
Interleukin-12 - genetics
Interleukin-2 - genetics
Measles virus
Medical sciences
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Pharmacology. Drug treatments
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Subacute Sclerosing Panencephalitis - genetics
Subacute Sclerosing Panencephalitis - immunology
Viral diseases
Viral diseases of the nervous system
Human
Nervous system diseases
Cytokine
Interleukin 12
IL-2
IL-12
Cerebral disorder
Inflammatory disease
Infection
IFN-γ
Interleukin 2
Sclerosing panencephalitis
Viral disease
Central nervous system disease
subacute sclerosing panencephalitis
Interferon
Polymorphism
Subacute
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Summary:Mutated measles virus variants have been claimed as the causing agent for subacute sclerosing panencephalitis (SSPE) developing several years after the recovery from measles infection. However, immune dysfunction may be considered related to a genetic susceptibility to this rare disease. Interleukin (IL)-2 -330 (rs2069 762) and +160 (rs2069 763), IL-12 p40 3′ UTR (rs3213113), and interferon (IFN)-γ +874 (rs2430561) polymorphisms are screened by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and PCR-sequence-specific priming (SSP) methods in 87 SSPE patients and 106 healthy controls (HCs) as candidate genes of susceptibility. The distribution of the IL12B genotypes (rs3213113) showed a trend for a significant difference (P = .053). The frequency of IL12B C allele (P = .04, OR: 1.6) and CC genotype (P = .03, OR: 3.2) were both higher in SSPE patients than in HC. The IL2 −330 genotypes revealed lower frequencies of GG genotype (P = .03, OR: 0.4) as well as G allele (P = .02, OR: 0.6) in SSPE. IL2 −330+160 TG haplotype was more frequent in patients (P = .005, OR: 1.8), whereas GG haplotype was less frequent, compared to controls (P = .02, OR: 0.6). IFNG +874 polymorphism revealed no difference. These findings implicate possible effects of genetic polymorphisms in the susceptibility to SSPE, which need to be confirmed in other populations.
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ISSN:1355-0284
1538-2443
DOI:10.1080/13550280701455383