Search Results - "Gökhan, S"

Metabolic functions of FABPs—mechanisms and therapeutic implications by Hotamisligil, Gökhan S., Bernlohr, David A.

“…Key Points Fatty acid-binding proteins (FABPs) are versatile proteins that can modulate lipid fluxes, trafficking, signalling and metabolism Fatty acid-binding…”
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Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes by Arruda, Ana Paula, Hotamisligil, Gökhan S.

“…A number of chronic metabolic pathologies, including obesity, diabetes, cardiovascular disease, asthma, and cancer, cluster together to present the greatest…”
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Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease by Hotamisligil, Gökhan S.

“…The endoplasmic reticulum (ER) is the major site in the cell for protein folding and trafficking and is central to many cellular functions. Failure of the ER's…”
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FABP4 Attenuates PPARγ and Adipogenesis and Is Inversely Correlated With PPARγ in Adipose Tissues by GARIN-SHKOLNIK, Tali, RUDICH, Assaf, HOTAMISLIGIL, Gökhan S, RUBINSTEIN, Menachem

“…Fatty acid binding protein 4 (FABP4, also known as aP2) is a cytoplasmic fatty acid chaperone expressed primarily in adipocytes and myeloid cells and…”
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Endoplasmic Reticulum Stress Is Reduced in Tissues of Obese Subjects After Weight Loss by GREGOR, Margaret F, LING YANG, FABBRINI, Elisa, MOHAMMED, B. Selma, EAGON, J. Christopher, HOTAMISLIGIL, Gökhan S, KLEIN, Samuel

“…Endoplasmic Reticulum Stress Is Reduced in Tissues of Obese Subjects After Weight Loss Margaret F. Gregor 1 , Ling Yang 1 , Elisa Fabbrini 2 , B. Selma…”
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Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity by Arruda, Ana Paula, Pers, Benedicte M, Parlakgül, Güneş, Güney, Ekin, Inouye, Karen, Hotamisligil, Gökhan S

“…Obesity-induced mitochondria stress and dysfunction results from disorganized mitochondria-associated ER membranes and excess calcium flux. Proper function of…”
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The Role of Endoplasmic Reticulum in Hepatic Lipid Homeostasis and Stress Signaling by Fu, Suneng, Watkins, Steven M., Hotamisligil, Gökhan S.

“…The endoplasmic reticulum (ER) is a critical site of protein, lipid, and glucose metabolism, lipoprotein secretion, and calcium homeostasis. Many of the…”
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Inflammatory mechanisms in obesity by Gregor, Margaret F, Hotamisligil, Gökhan S

“…The modern rise in obesity and its strong association with insulin resistance and type 2 diabetes have elicited interest in the underlying mechanisms of these…”
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Coordinated regulation of protein synthesis and degradation by mTORC1 by Zhang, Yinan, Nicholatos, Justin, Dreier, John R., Ricoult, Stéphane J. H., Widenmaier, Scott B., Hotamisligil, Gökhan S., Kwiatkowski, David J., Manning, Brendan D.

“…mTORC1 is known to stimulate protein synthesis; now, it is shown to also promote the synthesis of proteasomes, which degrade proteins into the amino acids…”
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Endoplasmic Reticulum Stress and Inflammation in Obesity and Diabetes by Hummasti, Sarah, Hotamisligil, Gökhan S

“…Obesity is a major problem worldwide that increases risk for a wide range of diseases, including diabetes and heart disease. As such, it is increasingly…”
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Adipokine FABP4 integrates energy stores and counterregulatory metabolic responses by Prentice, Kacey J., Saksi, Jani, Hotamisligil, Gökhan S.

“…Although counterregulatory hormones and mediators of the fight-or-flight responses are well defined at many levels, how energy stores per se are integrated…”
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Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity by Fu, Suneng, Yang, Ling, Li, Ping, Hofmann, Oliver, Dicker, Lee, Hide, Winston, Lin, Xihong, Watkins, Steven M., Ivanov, Alexander R., Hotamisligil, Gökhan S.

“…Lipid metabolism in obesity The function of the endoplasmic reticulum (ER) changes during obesity: in the liver, ER-associated protein synthesis slows down,…”
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Nutrient sensing and inflammation in metabolic diseases by Hotamisligil, Gökhan S, Erbay, Ebru

“…Key Points Mounting an immune response is a metabolically costly endeavour and cannot operate well under conditions of energy deficit. Energy surplus (for…”
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Inflammation and metabolic disorders by Hotamisligil, G.S

“…Metabolic and immune systems are among the most fundamental requirements for survival. Many metabolic and immune response pathways or nutrient- and…”
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Role of Endoplasmic Reticulum Stress and c-Jun NH2-Terminal Kinase Pathways in Inflammation and Origin of Obesity and Diabetes by HOTAMISLIGIL, Gökhan S

“…Metabolic and immune systems are the most fundamental requirements for survival, and many metabolic and immune response pathways or nutrient- and…”
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Endoplasmic reticulum stress and atherosclerosis by Hotamisligil, Gökhan S

“…Atherosclerosis and related cardiovascular diseases represent one of the greatest threats to human health worldwide. Despite important progress in prevention…”
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Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth by Nieman, Kristin M, Kenny, Hilary A, Penicka, Carla V, Ladanyi, Andras, Buell-Gutbrod, Rebecca, Zillhardt, Marion R, Romero, Iris L, Carey, Mark S, Mills, Gordon B, Hotamisligil, Gökhan S, Yamada, S Diane, Peter, Marcus E, Gwin, Katja, Lengyel, Ernst

“…Ovarian tumors preferentially metastasize to the omentum, a peritoneal fat layer. This report proposes that the reasons for this predilection stem from the…”
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Potential role for snoRNAs in PKR activation during metabolic stress by Youssef, Osama A., Safran, Sarah A., Nakamura, Takahisa, Nix, David A., Hotamisligil, Gökhan S., Bass, Brenda L.

“…Protein kinase RNA-activated (PKR) has long been known to be activated by viral double-stranded RNA (dsRNA) as part of the mammalian immune response. However,…”
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Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes by Özcan, Umut, Yilmaz, Erkan, Özcan, Lale, Furuhashi, Masato, Vaillancourt, Eric, Smith, Ross O, Görgün, Cem Z, Hotamisligil, Gökhan S

“…Endoplasmic reticulum (ER) stress is a key link between obesity, insulin resistance, and type 2 diabetes. Here, we provide evidence that this mechanistic link…”
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Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance by Yang, Ling, Li, Ping, Fu, Suneng, Calay, Ediz S., Hotamisligil, Gökhan S.

“…Autophagy is a homeostatic process involved in the bulk degradation of cytoplasmic components, including damaged organelles and proteins. In both genetic and…”
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