Search Results - "Göhlmann, Hinrich W"

Diarylquinoline Drug Active on the ATP Synthase of Mycobacterium tuberculosis by Andries, Koen, Verhasselt, Peter, Guillemont, Jerome, Göhlmann, Hinrich W. H, Neefs, Jean-Marc, Winkler, Hans, Van Gestel, Jef, Timmerman, Philip, Zhu, Min, Lee, Ennis, Williams, Peter, de Chaffoy, Didier, Huitric, Emma, Hoffner, Sven, Cambau, Emmanuelle, Truffot-Pernot, Chantal, Lounis, Nacer, Jarlier, Vincent

“…The incidence of tuberculosis has been increasing substantially on a worldwide basis over the past decade, but no tuberculosis-specific drugs have been…”
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FABIA: factor analysis for bicluster acquisition by Hochreiter, Sepp, Bodenhofer, Ulrich, Heusel, Martin, Mayr, Andreas, Mitterecker, Andreas, Kasim, Adetayo, Khamiakova, Tatsiana, Van Sanden, Suzy, Lin, Dan, Talloen, Willem, Bijnens, Luc, Göhlmann, Hinrich W. H., Shkedy, Ziv, Clevert, Djork-Arné

“…Motivation: Biclustering of transcriptomic data groups genes and samples simultaneously. It is emerging as a standard tool for extracting knowledge from gene…”
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Tales of 1,008 small molecules: phenomic profiling through live-cell imaging in a panel of reporter cell lines by Cox, Michael J., Jaensch, Steffen, Van de Waeter, Jelle, Cougnaud, Laure, Seynaeve, Daan, Benalla, Soulaiman, Koo, Seong Joo, Van Den Wyngaert, Ilse, Neefs, Jean-Marc, Malkov, Dmitry, Bittremieux, Mart, Steemans, Margino, Peeters, Pieter J., Wegner, Jörg Kurt, Ceulemans, Hugo, Gustin, Emmanuel, Chong, Yolanda T., Göhlmann, Hinrich W. H.

“…Phenomic profiles are high-dimensional sets of readouts that can comprehensively capture the biological impact of chemical and genetic perturbations in…”
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Integrating High-Dimensional Transcriptomics and Image Analysis Tools into Early Safety Screening: Proof of Concept for a New Early Drug Development Strategy by Verbist, Bie M. P, Verheyen, Geert R, Vervoort, Liesbet, Crabbe, Marjolein, Beerens, Dominiek, Bosmans, Cindy, Jaensch, Steffen, Osselaer, Steven, Talloen, Willem, Van den Wyngaert, Ilse, Van Hecke, Geert, Wuyts, Dirk, Van Goethem, Freddy, Göhlmann, Hinrich W. H

“…During drug discovery and development, the early identification of adverse effects is expected to reduce costly late-stage failures of candidate drugs. As…”
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Progressive leukoencephalopathy impairs neurobehavioral development in sialin-deficient mice by Stroobants, Stijn, Van Acker, Nathalie G.G., Verheijen, Frans W., Goris, Ilse, Daneels, Guy F.T., Schot, Rachel, Verbeek, Elly, Knaapen, Michiel W.M., De Bondt, An, Göhlmann, Hinrich W., Crauwels, Marion L.A., Mancini, Grazia M.S., Andries, Luc J., Moechars, Dieder W.E., D'Hooge, Rudi

“…Slc17a5−/− mice represent an animal model for the infantile form of sialic acid storage disease (SASD). We analyzed genetic and histological time-course…”
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I/NI-calls for the exclusion of non-informative genes: a highly effective filtering tool for microarray data by Talloen, Willem, Clevert, Djork-Arné, Hochreiter, Sepp, Amaratunga, Dhammika, Bijnens, Luc, Kass, Stefan, Göhlmann, Hinrich W.H.

“…Motivation: DNA microarray technology typically generates many measurements of which only a relatively small subset is informative for the interpretation of…”
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Alterations in the Brain–Gut Axis Underlying Visceral Chemosensitivity in Nippostrongylus brasiliensis- Infected Mice by Aerssens, Jeroen, Hillsley, Kirk, Peeters, Pieter J, de Hoogt, Ronald, Stanisz, Andrzej, Lin, Jia–Hui, Van den Wyngaert, Ilse, Göhlmann, Hinrich W, Grundy, David, Stead, Ronald H, Coulie, Bernard

“…Background & Aims: Visceral hypersensitivity, a hallmark of irritable bowel syndrome, is generally considered to be mechanosensitive in nature and mediated via…”
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Understanding drugs in breast cancer through drug sensitivity screening by Uhr, Katharina, Prager-van der Smissen, Wendy J. C., Heine, Anouk A. J., Ozturk, Bahar, Smid, Marcel, Göhlmann, Hinrich W. H., Jager, Agnes, Foekens, John A., Martens, John W. M.

“…With substantial numbers of breast tumors showing or acquiring treatment resistance, it is of utmost importance to develop new agents for the treatment of the…”
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A genetics-led approach defines the drug target landscape of 30 immune-related traits by Fang, Hai, De Wolf, Hans, Knezevic, Bogdan, Burnham, Katie L., Osgood, Julie, Sanniti, Anna, Lledó Lara, Alicia, Kasela, Silva, De Cesco, Stephane, Wegner, Jörg K., Handunnetthi, Lahiru, McCann, Fiona E., Chen, Liye, Sekine, Takuya, Brennan, Paul E., Marsden, Brian D., Damerell, David, O’Callaghan, Chris A., Bountra, Chas, Bowness, Paul, Sundström, Yvonne, Milani, Lili, Berg, Louise, Göhlmann, Hinrich W., Peeters, Pieter J., Fairfax, Benjamin P., Sundström, Michael, Knight, Julian C.

“…Most candidate drugs currently fail later-stage clinical trials, largely due to poor prediction of efficacy on early target selection 1 . Drug targets with…”
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Alterations in Mucosal Immunity Identified in the Colon of Patients With Irritable Bowel Syndrome by Aerssens, Jeroen, Camilleri, Michael, Talloen, Willem, Thielemans, Leen, Göhlmann, Hinrich W.H, Van den Wyngaert, Ilse, Thielemans, Theo, De Hoogt, Ronald, Andrews, Christopher N, Bharucha, Adil E, Carlson, Paula J, Busciglio, Irene, Burton, Duane D, Smyrk, Thomas, Urrutia, Raul, Coulie, Bernard

“…Background & Aims: Irritable bowel syndrome (IBS) has been associated with mucosal dysfunction, mild inflammation, and altered colonic bacteria. We used…”
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Connecting gene expression data from connectivity map and in silico target predictions for small molecule mechanism-of-action analysis by Ravindranath, Aakash Chavan, Perualila-Tan, Nolen, Kasim, Adetayo, Drakakis, Georgios, Liggi, Sonia, Brewerton, Suzanne C, Mason, Daniel, Bodkin, Michael J, Evans, David A, Bhagwat, Aditya, Talloen, Willem, Göhlmann, Hinrich W H, Shkedy, Ziv, Bender, Andreas

“…Integrating gene expression profiles with certain proteins can improve our understanding of the fundamental mechanisms in protein-ligand binding. This paper…”
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Identification and complementation of frameshift mutations associated with loss of cytadherence in Mycoplasma pneumoniae by Fisseha, M, Göhlmann, H W, Herrmann, R, Krause, D C

“…Mycoplasma pneumoniae cytadherence is mediated by a specialized, polar attachment organelle. Certain spontaneously arising cytadherence mutants (designated…”
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Weighted similarity-based clustering of chemical structures and bioactivity data in early drug discovery by Perualila-Tan, Nolen Joy, Shkedy, Ziv, Talloen, Willem, Göhlmann, Hinrich W H, Moerbeke, Marijke Van, Kasim, Adetayo

“…The modern process of discovering candidate molecules in early drug discovery phase includes a wide range of approaches to extract vital information from the…”
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Identification of a small RNA within the pdh gene cluster of Mycoplasma pneumoniae and Mycoplasma genitalium by Göhlmann, H W, Weiner, 3rd, J, Schön, A, Herrmann, R

“…A highly abundant and heterogeneous small RNA about 205 to 210 bases long named MP200 RNA has been identified in Mycoplasma pneumoniae. It was localized on the…”
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Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism by Koul, Anil, Vranckx, Luc, Dhar, Neeraj, Göhlmann, Hinrich W.H., Özdemir, Emre, Neefs, Jean-Marc, Schulz, Melanie, Lu, Ping, Mørtz, Ejvind, McKinney, John D., Andries, Koen, Bald, Dirk

“…Bedaquiline (BDQ), an ATP synthase inhibitor, is the first drug to be approved for treatment of multidrug-resistant tuberculosis in decades. Though BDQ has…”
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Graphical Exploration of Gene Expression Data: A Comparative Study of Three Multivariate Methods by Wouters, Luc, Göhlmann, Hinrich W., Bijnens, Luc, Kass, Stefan U., Molenberghs, Geert, Lewi, Paul J.

“…This article describes three multivariate projection methods and compares them for their ability to identify clusters of biological samples and genes using…”
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The high-level similarity of some disparate gene expression measures by Raghavan, Nandini, De Bondt, An M. I. M., Talloen, Willem, Moechars, Dieder, Göhlmann, Hinrich W. H., Amaratunga, Dhammika

“…Probe-level data from Affymetrix GeneChips can be summarized in many ways to produce probe-set level gene expression measures (GEMs). Disturbingly, the…”
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Genomic Biomarkers for a Binary Clinical Outcome in Early Drug Development Microarray Experiments by Van Sanden, Suzy, Shkedy, Ziv, Burzykowski, Tomasz, Göhlmann, Hinrich W. H., Talloen, Willem, Bijnens, Luc

“…In this article, we discuss methods to select three different types of genes (treatment related, response related, or both) and investigate whether they can…”
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Molecular profiling of murine sensory neurons in the nodose and dorsal root ganglia labeled from the peritoneal cavity by Peeters, Pieter J, Aerssens, Jeroen, de Hoogt, Ronald, Stanisz, Andrzej, Gohlmann, Hinrich W, Hillsley, Kirk, Meulemans, Ann, Grundy, David, Stead, Ronald H, Coulie, Bernard

“…1 Johnson and Johnson Pharmaceutical Research and Development, Department of Internal Medicine, Beerse, Belgium 2 Holburn Group of Companies, Bowmanville,…”
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Analysis of Affymetrix GeneChip data using amplified RNA by Cope, Leslie, Hartman, Scott M, Göhlmann, Hinrich W H, Tiesman, Jay P, Irizarry, Rafael A

“…When small biological samples are collected by microdissection or other methods, amplification techniques are required to provide sufficient target for…”
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