Search Results - "Górna, Maria Wiktoria"
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A unique mRNA decapping complex in trypanosomes
Published in Nucleic acids research (11-08-2023)“…Abstract Removal of the mRNA 5′ cap primes transcripts for degradation and is central for regulating gene expression in eukaryotes. The canonical decapping…”
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A Uniform Benchmark for Testing SsrA-Derived Degrons in the Escherichia coli ClpXP Degradation Pathway
Published in Molecules (Basel, Switzerland) (30-09-2021)“…The ssrA degron is commonly used in fusion proteins to control protein stability in bacteria or as an interaction module. These applications often rely on the…”
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Applications of Bacterial Degrons and Degraders - Toward Targeted Protein Degradation in Bacteria
Published in Frontiers in molecular biosciences (07-05-2021)“…A repertoire of proteolysis-targeting signals known as degrons is a necessary component of protein homeostasis in every living cell. In bacteria, degrons can…”
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Immunoinformatic design of a putative multi-epitope vaccine candidate against Trypanosoma brucei gambiense
Published in Computational and structural biotechnology journal (01-01-2022)“…[Display omitted] Human African trypanosomiasis (HAT) is a neglected tropical disease that is caused by flagellated parasites of the genus Trypanosoma. HAT…”
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Targeted protein degradation might present a novel therapeutic approach in the fight against African trypanosomiasis
Published in European journal of pharmaceutical sciences (01-07-2023)“…African trypanosomiasis (AT) is a hemoparasitic disease caused by infection with African trypanosomes and it is prevalent in many sub-Saharan African…”
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The Role of Electrostatic Interactions in IFIT5-RNA Complexes Predicted by the UBDB+EPMM Method
Published in The journal of physical chemistry. B (17-11-2022)“…Electrostatic energy has a significant contribution to intermolecular interaction energy, especially in biological systems. Unfortunately, precise quantum…”
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The Effect of Mutations in the TPR and Ankyrin Families of Alpha Solenoid Repeat Proteins
Published in Frontiers in bioinformatics (06-07-2021)“…Protein repeats are short, highly similar peptide motifs that occur several times within a single protein, for example the TPR and Ankyrin repeats…”
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β-Sitosterol could serve as a dual inhibitor of Trypanosoma congolense sialidase and phospholipase A2: in vitro kinetic analyses and molecular dynamic simulations
Published in Molecular diversity (01-08-2023)“…The involvement of Trypanosoma congolense sialidase alongside phospholipase A 2 has been widely accepted as the major contributing factor to anemia during…”
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β-Sitosterol could serve as a dual inhibitor of Trypanosoma congolense sialidase and phospholipase A 2 : in vitro kinetic analyses and molecular dynamic simulations
Published in Molecular diversity (01-08-2023)“…The involvement of Trypanosoma congolense sialidase alongside phospholipase A has been widely accepted as the major contributing factor to anemia during…”
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