Administration of loperamide and addition of wheat bran to the diets of weaner pigs decrease the incidence of diarrhoea and enhance their gut maturation

The influence of fibre inclusion and transit time regulation on the performance, health status, microbial activity and population, physico-chemical characteristics of the hindgut digesta and intestinal morphology in early weaned pigs were examined. For these experiments, wheat bran (WB) was used as...

Full description

Saved in:

Bibliographic Details
Published in:	British journal of nutrition Vol. 103; no. 6; pp. 879 - 885
Main Authors:	Molist Gasa, Francesc, Ywazaki, Mauro, Gómez de Segura Ugalde, Arantza, Hermes, Rafael Gustavo, Gasa Gasó, Josep, Pérez Hernández, José Francisco
Format:	Journal Article
Language:	English
Published:	Cambridge, UK Cambridge University Press 28-03-2010
Subjects:	Acetic acid Acetic Acid - analysis Acids animal development animal health animal nutrition animal performance Animals antidiarrhea agents Antidiarrheals - administration & dosage Biological and medical sciences Body weight Butyric Acid - analysis chemical concentration crude protein diarrhea Diarrhea - prevention & control Diarrhea - veterinary Diet Dietary fiber Dietary Fiber - administration & dosage digesta Digesta transit time digestible protein Digestion Enterobacteriaceae Enterobacteriaceae - growth & development Fatty Acids, Volatile - analysis Feces - chemistry Feces - microbiology feed intake feeder pigs Feeding. Feeding behavior Fermentation Fundamental and applied biological sciences. Psychology Gastroenterology Gastrointestinal Transit health status Hogs intestinal microorganisms intestines Intestines - chemistry Intestines - growth & development Intestines - microbiology Loperamide Loperamide - administration & dosage Metabolism and Metabolic Studies Microbial activity microbial colonization microbial population Microbiota nutrient-drug interactions Nutrition Organic matter physicochemical properties piglet feeding Piglets Propionates - analysis propionic acid short chain fatty acids Swine Swine Diseases - prevention & control Triticum aestivum Vertebrates: anatomy and physiology, studies on body, several organs or systems Weaning Weight Gain Wheat bran Digesta transit time Loperamide Microbiota Piglets Wheat bran Addition Transit time Digestive system Gut Diarrhea Microflora Feeding Incidence Pig Vertebrata Mammalia Decrease Diet Cereal Digestive diseases Intestinal disease Artiodactyla Wheat Ungulata
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The influence of fibre inclusion and transit time regulation on the performance, health status, microbial activity and population, physico-chemical characteristics of the hindgut digesta and intestinal morphology in early weaned pigs were examined. For these experiments, wheat bran (WB) was used as fibre source and loperamide as a drug (LOP) to increase the digesta transit time. In Expt 1, a total of 128 early weaned pigs were randomly distributed in a 2 × 2 factorial combination of WB inclusion (0 v. 40 g/kg) and LOP administration (0 v. 0·07 mg/kg body weight) during 13 d. For Expt 2, a total of twenty-four piglets were allotted to three dietary treatments for 15 d with the same basal diet (control diet) as Expt 1; a diet with 80 g/kg of WB and the combination of WB and LOP. In Expt 1, LOP improved the average daily feed intake and average daily gain of the animals (P = 0·001 and 0·007, respectively). The same result was obtained when WB was combined with LOP. The WB–LOP group also showed a higher concentration of SCFA (P = 0·013), acetic acid (P = 0·004) and propionic acid (P = 0·093). On the other hand, WB inclusion reduced the organic matter and crude protein digestibility (P = 0·001) and tended to decrease the enterobacteria population (P = 0·089). In Expt 2, WB increased the butyric acid concentration (P = 0·086). We concluded that the inclusion of WB to modify the intestinal microbiota activity combined with LOP may be beneficial to animal health and performance.
Bibliography:	http://dx.doi.org/10.1017/S0007114509992637 ArticleID:99263 ark:/67375/6GQ-WWK45X91-8 PII:S0007114509992637 istex:2D6E0EB0C90FBE3DE04B24A38B554C4EAA0FA2E6 Abbreviations: ADG, average daily gain; BW, body weight; CP, crude protein; CT, control diet; FM, fresh matter; GIT, gastrointestinal tract; LOP, loperamide; MTT, minimum transit time; OM, organic matter; WB, wheat bran; WRC, water retention capacity ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0007-1145 1475-2662
DOI:	10.1017/S0007114509992637