Search Results - "Gómez Barrio, Alicia"

Synthesis and Biophysical and Biological Studies of N‑Phenylbenzamide Derivatives Targeting Kinetoplastid Parasites by Nué-Martinez, J. Jonathan, Cisneros, David, Moreno-Blázquez, María del Valle, Fonseca-Berzal, Cristina, Manzano, José Ignacio, Kraeutler, Damien, Ungogo, Marzuq A., Aloraini, Maha A., Elati, Hamza A. A., Ibáñez-Escribano, Alexandra, Lagartera, Laura, Herraiz, Tomás, Gamarro, Francisco, de Koning, Harry P., Gómez-Barrio, Alicia, Dardonville, Christophe

“…The AT-rich mitochondrial DNA (kDNA) of trypanosomatid parasites is a target of DNA minor groove binders. We report the synthesis, antiprotozoal screening, and…”
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Thio- and selenosemicarbazones as antiprotozoal agents against Trypanosoma cruzi and Trichomonas vaginalis by Ibáñez-Escribano, Alexandra, Fonseca-Berzal, Cristina, Martínez-Montiel, Mónica, Álvarez-Márquez, Manuel, Gómez-Núñez, María, Lacueva-Arnedo, Manuel, Espinosa-Buitrago, Teresa, Martín-Pérez, Tania, Escario, José Antonio, Merino-Montiel, Penélope, Montiel-Smith, Sara, Gómez-Barrio, Alicia, López, Óscar, Fernández-Bolaños, José G

“…Herein, we report the preparation of a panel of Schiff bases analogues as antiprotozoal agents by modification of the stereoelectronic effects of the…”
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Development of novel benznidazole formulations: Physicochemical characterization and in vivo evaluation on parasitemia reduction in Chagas disease by Palmeiro-Roldán, Ricardo, Fonseca-Berzal, Cristina, Gómez-Barrio, Alicia, Arán, Vicente J., Escario, José A., Torrado-Durán, Susana, Torrado-Santiago, Santiago

“…[Display omitted] This work aims to develop novel benznidazole (BZN) solid dispersions (SD) to improve its solubility and bioavailability properties…”
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Antibacterial, Trichomonacidal, and Cytotoxic Activities of Pleopeltis crassinervata Extracts by Anacleto-Santos, Jhony, Vega-Ávila, Elisa, Pacheco, Leticia, Lacueva-Arnedo, Manuel, Gómez-Barrio, Alicia, Ibáñez-Escribano, Alexandra, López-Pérez, Teresa de Jesús, Casarrubias-Tabarez, Brenda, Calzada, Fernando, López-Camacho, Perla Yolanda, Rivera-Fernández, Norma

“…is a fern documented in ethnobotanical records for its use in Mexican traditional medicine to treat gastric disorders and mouth ulcers. Consequently,…”
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In vitro phenotypic screening of 7-chloro-4-amino(oxy)quinoline derivatives as putative anti-Trypanosoma cruzi agents by Fonseca-Berzal, Cristina, Rojas Ruiz, Fernando A, Escario, José A, Kouznetsov, Vladimir V, Gómez-Barrio, Alicia

“…In this study, a series of 22 pre-synthesized 7-chloro-4-amino(oxy)quinoline derivatives was assayed in vitro as potential antichagasic agents. A primary…”
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Synthesis and antimalarial activity of new heterocyclic hybrids based on chloroquine and thiazolidinone scaffolds by Rojas Ruiz, Fernando A., García-Sánchez, Rory N., Estupiñan, Santiago Villabona, Gómez-Barrio, Alicia, Torres Amado, Diego F., Pérez-Solórzano, Berta Martín, Nogal-Ruiz, Juan J., Martínez-Fernández, Antonio R., Kouznetsov, Vladimir V.

“…A series of new 21 chloroquine molecules 1–4, 8–24 were synthesized and screened for their antimalarial activity against chloroquine (CQ)-sensitive 3D7 and…”
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New Imidazole-Based Compounds Active Against Trypanosoma cruzi by Adeyemi, Oluyomi Stephen, Molina, María Teresa, Eseola, Abiodun Omokehinde, Fonseca-Berzal, Cristina, Gómez-Barrio, Alicia

“…Current drugs available for the treatment of Chagas disease are fraught with several challenges including severe toxicity and limited efficacy. These factors…”
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Sequestration of host-CD59 as potential immune evasion strategy of Trichomonas vaginalis by Ibáñez-Escribano, Alexandra, Nogal-Ruiz, Juan José, Pérez-Serrano, Jorge, Gómez-Barrio, Alicia, Escario, J. Antonio, Alderete, J.F.

“…•No sequence homology in Trichomonas vaginalis genome with CD59 human gene.•IFI detection of CD59 on T. vaginalis surface of flagellates recovered from…”
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Development of resazurin microtiter assay for drug sensibility testing of Trypanosoma cruzi epimastigotes by ROLON, Miriam, VEGA, Celeste, ESCARIO, José A, GOMEZ-BARRIO, Alicia

“…A quantitative colorimetric assay using the oxidation–reduction indicator resazurin was developed to measure cytotoxicity of compounds against the protozoan…”
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Trypanocidal Activity of Long Chain Diamines and Aminoalcohols by Legarda-Ceballos, Ana L, del Olmo, Esther, López-Abán, Julio, Escarcena, Ricardo, Bustos, Luis A, Fonseca-Berzal, Cristina, Gómez-Barrio, Alicia, Dib, Juan C, San Feliciano, Arturo, Muro, Antonio

“…Thirteen aminoalcohols and eight diamines were obtained and tested against Trypanosoma cruzi epimastigotes strains MG, JEM and CL-B5 clone. Some of them were…”
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A novel non-stochastic quadratic fingerprints-based approach for the ‘in silico’ discovery of new antitrypanosomal compounds by Montero-Torres, Alina, Vega, María Celeste, Marrero-Ponce, Yovani, Rolón, Miriam, Gómez-Barrio, Alicia, Escario, José Antonio, Arán, Vicente J., Martínez-Fernández, Antonio R., Meneses-Marcel, Alfredo

“…A non-stochastic quadratic fingerprints-based approach is introduced to classify and design, in a rational way, new antitrypanosomal compounds. A data set of…”
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New antitrichomonal drug-like chemicals selected by bond (edge)-based TOMOCOMD-CARDD descriptors by Meneses-Marcel, Alfredo, Rivera-Borroto, Oscar M, Marrero-Ponce, Yovani, Montero, Alina, Machado Tugores, Yanetsy, Escario, José Antonio, Gómez Barrio, Alicia, Montero Pereira, David, Nogal, Juan José, Kouznetsov, Vladimir V, Ochoa Puentes, Cristian, Bohórquez, Arnold R, Grau, Ricardo, Torrens, Francisco, Ibarra-Velarde, Froylán, Arán, Vicente J

“…Bond-based quadratic indices, new TOMOCOMD-CARDD molecular descriptors, and linear discriminant analysis (LDA) were used to discover novel lead…”
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Antichagasic, Leishmanicidal, and Trichomonacidal Activity of 2‐Benzyl‐5‐nitroindazole‐Derived Amines by Fonseca‐Berzal, Cristina, Ibáñez‐Escribano, Alexandra, Vela, Nerea, Cumella, José, Nogal‐Ruiz, Juan José, Escario, José Antonio, da Silva, Patrícia Bernardino, Batista, Marcos Meuser, Soeiro, Maria de Nazaré C., Sifontes‐Rodríguez, Sergio, Meneses‐Marcel, Alfredo, Gómez‐Barrio, Alicia, Arán, Vicente J.

“…Three different series of new 5‐nitroindazole derivatives—1‐(ω‐aminoalkyl)‐2‐benzylindazolin‐3‐ones (series A; ten compounds),…”
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Biological characterization of a beta-galactosidase expressing clone of Trypanosoma cruzi CL strain by Le-Senne, Ana, Muelas-Serrano, Susana, Fernández-Portillo, Carlos, Escario, José Antonio, Gómez-Barrio, Alicia

“…Clone CL B5 of Trypanosoma cruzi is a beta-galactosidase expressing organism that was genetically transfected to be used for in vitro pharmacological…”
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In vitro trichomonacidal activity and preliminary in silico chemometric studies of 5-nitroindazolin-3-one and 3-alkoxy-5-nitroindazole derivatives by Ibáñez-Escribano, Alexandra, Nogal-Ruiz, Juan José, Gómez-Barrio, Alicia, Arán, Vicente J, Escario, José Antonio

“…A selection of 1,2-disubstituted 5-nitroindazolin-3-ones (1-19) and 3-alkoxy-5-nitroindazoles substituted at positions 1 (20-24) or 2 (25-39) from our in-house…”
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In Vitro and in Vivo Anti- Trypanosoma cruzi Activity of a Novel Nitro-derivative by Susana Muelas-Serrano, Ana Le-Senne, Carlos Fernández-Portillo, Juan José Nogal, Carmen Ochoa, Alicia Gómez-Barrio

“…Nitroarylidenemalononitriles and their cyanoacetamide derivatives with remarkable anti-epimastigote properties, were synthesized attempting to obtain new…”
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2H-Benzimidazole 1,3-Dioxide Derivatives:  A New Family of Water-Soluble Anti-Trypanosomatid Agents by Boiani, Mariana, Boiani, Lucía, Denicola, Ana, Torres de Ortiz, Susana, Serna, Elva, Vera de Bilbao, Ninfa, Sanabria, Luis, Yaluff, Gloria, Nakayama, Héctor, Rojas de Arias, Antonieta, Vega, Celeste, Rolan, Miriam, Gómez-Barrio, Alicia, Cerecetto, Hugo, González, Mercedes

“…Three series of benzimidazole N-oxide derivatives were developed and were examined for their activity against trypanosomatid parasites (Trypanosoma cruzi and…”
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Synthesis and Antiparasitic Properties of New 4-N-Benzylamino-4-Hetarylbut-1-enes by Kouznetsov, Vladimir V., Castro, Juliette Rivero, Puentes, Cristian Ochoa, Stashenko, Elena E., Martínez, Jairo René, Ochoa, Carmen, Pereira, David Montero, Ruiz, Juan J. Nogal, Portillo, Carlos Fernández, Serrano, Susana Muelas, Barrio, Alicia Gómez, Bahsas, Alí, Amaro-Luis, Juan

“…New derivatives of 4‐N‐benzylamino‐4‐hetarylbut‐1‐ene containing a pyridyl nucleus were synthesized from benzylamines and pyridine aldehydes. N‐oxide…”
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Validation of a modified fluorimetric assay for the screening of trichomonacidal drugs by Escribano, Alexandra Ibáñez, Marcel, Alfredo Meneses, Tugores, Yanetsy Machado, Ruiz, Juan José Nogal, Redó, Vicente J Arán, García-Trevijano, José Antonio Escario, Barrio, Alicia Gómez

“…A fluorimetric microassay that uses a redox dye to determine the viability of the flagellate Trichomonas vaginalis has been optimised to provide a more…”
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Predicting antitrichomonal activity: A computational screening using atom-based bilinear indices and experimental proofs by Marrero-Ponce, Yovani, Meneses-Marcel, Alfredo, Castillo-Garit, Juan A., Machado-Tugores, Yanetsy, Escario, José Antonio, Barrio, Alicia Gómez, Pereira, David Montero, Nogal-Ruiz, Juan José, Arán, Vicente J., Martínez-Fernández, Antonio R., Torrens, Francisco, Rotondo, Richard, Ibarra-Velarde, Froylán, Alvarado, Ysaias J.

“…The two dimensions of TOMOCOMD-CARDD method: from dataset to QSAR models, and from QSAR models to biosilico drug discovery. Existing Trichomonas vaginalis…”
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