Search Results - "Gómez, Valentí"

Radiation therapy and the innate immune response: Clinical implications for immunotherapy approaches by Gómez, Valentí, Mustapha, Rami, Ng, Kenrick, Ng, Tony

“…Radiation therapy is an essential component of cancer care, contributing up to 40% of curative cancer treatment regimens. It creates DNA double‐strand breaks…”
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HER2 Mediates PSMA/mGluR1-Driven Resistance to the DS-7423 Dual PI3K/mTOR Inhibitor in PTEN Wild-type Prostate Cancer Models by Gómez, Valentí, Galazi, Myria, Weitsman, Gregory, Monypenny, James, Al-Salemee, Fahad, Barber, Paul R, Ng, Kenrick, Beatson, Richard, Szokol, Bálint, Orfi, László, Mullen, Greg, Vanhaesebroeck, Bart, Chowdhury, Simon, Leung, Hing Y, Ng, Tony

“…Prostate cancer remains a major cause of male mortality. Genetic alteration of the PI3K/AKT/mTOR pathway is one of the key events in tumor development and…”
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Regulatory and Functional Connection of Microphthalmia-Associated Transcription Factor and Anti-Metastatic Pigment Epithelium Derived Factor in Melanoma by Fernández-Barral, Asunción, Orgaz, Jose Luis, Baquero, Pablo, Ali, Zaheer, Moreno, Alberto, Tiana, María, Gómez, Valentí, Riveiro-Falkenbach, Erica, Cañadas, Carmen, Zazo, Sandra, Bertolotto, Corine, Davidson, Irwin, Rodríguez-Peralto, Jose Luis, Palmero, Ignacio, Rojo, Federico, Jensen, Lasse Dahl, del Peso, Luis, Jiménez, Benilde

“…Abstract Pigment epithelium-derived factor (PEDF), a member of the serine protease inhibitor superfamily, has potent anti-metastatic effects in cutaneous…”
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PTOV1 Enables the Nuclear Translocation and Mitogenic Activity of Flotillin-1, a Major Protein of Lipid Rafts by Santamaría, Anna, Castellanos, Elisabeth, Gómez, Valentí, Benedit, Patricia, Renau-Piqueras, Jaime, Morote, Juan, Reventós, Jaume, Thomson, Timothy M, Paciucci, Rosanna

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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RNA Activation-A Novel Approach to Therapeutically Upregulate Gene Transcription by Tan, Choon Ping, Sinigaglia, Laura, Gomez, Valentí, Nicholls, Joanna, Habib, Nagy A

“…RNA activation (RNAa) is a mechanism whereby RNA oligos complementary to genomic sequences around the promoter region of genes increase the transcription…”
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Hypoxia negatively regulates antimetastatic PEDF in melanoma cells by a hypoxia inducible factor-independent, autophagy dependent mechanism by Fernández-Barral, Asunción, Orgaz, José Luis, Gomez, Valentí, del Peso, Luis, Calzada, María José, Jiménez, Benilde

“…Pigment epithelium-derived factor (PEDF), a member of the serine protease inhibitor (SERPIN) superfamily, displays a potent antiangiogenic and antimetastatic…”
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Breast cancer-associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells by Gómez, Valentí, Eykyn, Thomas R, Mustapha, Rami, Flores-Borja, Fabián, Male, Victoria, Barber, Paul R, Patsialou, Antonia, Green, Ryan, Panagaki, Fani, Li, Chun W, Fruhwirth, Gilbert O, Ros, Susana, Brindle, Kevin M, Ng, Tony

“…Tumor-associated macrophages (TAMs) can exist in pro- and anti-inflammatory states. Anti-inflammatory TAMs (also referred to as M2-polarized) generally…”
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Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2 by Guilhamon, Paul, Eskandarpour, Malihe, Halai, Dina, Wilson, Gareth A., Feber, Andrew, Teschendorff, Andrew E., Gomez, Valenti, Hergovich, Alexander, Tirabosco, Roberto, Fernanda Amary, M., Baumhoer, Daniel, Jundt, Gernot, Ross, Mark T., Flanagan, Adrienne M., Beck, Stephan

“…Isocitrate dehydrogenase ( IDH ) genes 1 and 2 are frequently mutated in acute myeloid leukaemia (AML), low-grade glioma, cholangiocarcinoma (CC) and…”
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The Pro-apoptotic STK38 Kinase Is a New Beclin1 Partner Positively Regulating Autophagy by Joffre, Carine, Dupont, Nicolas, Hoa, Lily, Gomez, Valenti, Pardo, Raul, Gonçalves-Pimentel, Catarina, Achard, Pauline, Bettoun, Audrey, Meunier, Brigitte, Bauvy, Chantal, Cascone, Ilaria, Codogno, Patrice, Fanto, Manolis, Hergovich, Alexander, Camonis, Jacques

“…Autophagy plays key roles in development, oncogenesis, cardiovascular, metabolic, and neurodegenerative diseases. Hence, understanding how autophagy is…”
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The Hippo pathway in disease and therapy: cancer and beyond by Gomez, Marta, Gomez, Valenti, Hergovich, Alexander

“…The Hippo tumour suppressor pathway co-ordinates cell proliferation, cell death and cell differentiation to regulate tissue growth control. In mammals, a…”
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A novel DNA-binding motif in prostate tumor overexpressed-1 (PTOV1) required for the expression of ALDH1A1 and CCNG2 in cancer cells by Maggio, Valentina, Cánovas, Verónica, Félix, Alex J., Gómez, Valentí, de Torres, Inés, Semidey, María Eugenia, Morote, Juan, Noé, Verónique, Ciudad, Carlos J., Paciucci, Rosanna

“…PTOV1 is a transcription and translation regulator and a promoter of cancer progression. Its overexpression in prostate cancer induces transcription of drug…”
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Regulatory and Functional Connection of Microphthalmia-Associated Transcription Factor and Anti-Metastatic Pigment Epithelium Derived Factor in Melanoma1 by Fernández-Barral, Asunción, Orgaz, Jose Luis, Baquero, Pablo, Ali, Zaheer, Moreno, Alberto, Tiana, María, Gómez, Valentí, Riveiro-Falkenbach, Erica, Cañadas, Carmen, Zazo, Sandra, Bertolotto, Corine, Davidson, Irwin, Rodríguez-Peralto, Jose Luis, Palmero, Ignacio, Rojo, Federico, Jensen, Lasse Dahl, del Peso, Luis, Jiménez, Benilde

“…Pigment epithelium-derived factor (PEDF), a member of the serine protease inhibitor superfamily, has potent anti-metastatic effects in cutaneous melanoma…”
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Regulation of Aurora B Kinase by the Lipid Raft Protein Flotillin-1 by Gómez, Valentí, Sesé, Marta, Santamaría, Anna, Martínez, Juan D., Castellanos, Elisabet, Soler, Marta, Thomson, Timothy M., Paciucci, Rosanna

“…The lipid raft protein Flotillin-1 was previously shown to be required for cell proliferation. Here we show that it is critical for the maintenance of the…”
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Abstract 382: MTL-STING restores endogenous STING expression for improving efficacy of cancer therapeutics by Tan, Choon Ping, Stathaki, Konstantina Skourti, Ryan, Brid M, Gomez, Valentí, Sinigaglia, Laura, Hegre, Siv Anita, Habib, Robert, Rossi, John J, Habib, Nagy A

“…Abstract cGAS-cGAMP-STING is essential for sensing foreign DNA from pathogens or self-DNA from dying cancer cells. Activation of this pathway is critical for…”
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OLA1 in Centrosome Biology alongside the BRCA1/BARD1 Complex: Looking beyond Centrosomes by Gomez, Valenti, Hergovich, Alexander

“…In this issue of Molecular Cell, Chiba and colleagues (Matsuzawa et al., 2014) identify Obg-like ATPase 1 (OLA1) as an additional member of the…”
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The characterisation of LATS2 kinase regulation in Hippo-YAP signalling by Hoa, Lily, Kulaberoglu, Yavuz, Gundogdu, Ramazan, Cook, Dorthe, Mavis, Merdiye, Gomez, Marta, Gomez, Valenti, Hergovich, Alexander

“…By controlling the YAP1 proto-oncoprotein Hippo signalling plays important roles in cancer-associated processes. Current evidence suggests that the Hippo…”
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hMOB2 deficiency impairs homologous recombination-mediated DNA repair and sensitises cancer cells to PARP inhibitors by Gundogdu, Ramazan, Erdogan, M. Kadir, Ditsiou, Angeliki, Spanswick, Victoria, Garcia-Gomez, Juan Jose, Hartley, John A., Esashi, Fumiko, Hergovich, Alexander, Gomez, Valenti

“…Monopolar spindle-one binder (MOBs) proteins are evolutionarily conserved and contribute to various cellular signalling pathways. Recently, we reported that…”
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Regulation of DNA damage responses and cell cycle progression by hMOB2 by Gomez, Valenti, Gundogdu, Ramazan, Gomez, Marta, Hoa, Lily, Panchal, Neelam, O'Driscoll, Mark, Hergovich, Alexander

“…Mps one binder proteins (MOBs) are conserved regulators of essential signalling pathways. Biochemically, human MOB2 (hMOB2) can inhibit NDR kinases by…”
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Constitutively active NDR1-PIF kinase functions independent of MST1 and hMOB1 signalling by Cook, Dorthe, Hoa, Lily Y., Gomez, Valenti, Gomez, Marta, Hergovich, Alexander

“…The human MST1/hMOB1/NDR1 tumour suppressor cascade regulates important cellular processes, such as centrosome duplication. hMOB1/NDR1 complex formation…”
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Las nuevas tecnologías y los medios de comunicación y su incidencia en el consumo de los niños y los jóvenes by Gómez Oliver, Valentí

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