Search Results - "Gómez, Karina A."

Activation‐induced marker assays for identification of Trypanosoma cruzi‐specific CD4 or CD8 T cells in chronic Chagas disease patients by Ferragut, Fátima, Cruz, Karen M., Gallardo, Juan P., Fernández, Marisa, Hernández Vasquez, Yolanda, Gómez, Karina A.

“…Antigen‐specific T cells are central to the adaptive immune response against T. cruzi infection and underpin the efficacy of on‐going vaccine strategies. In…”
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Characterization of Novel Trypanosoma cruzi -Specific Antigen with Potential Use in the Diagnosis of Chagas Disease by Ossowski, Micaela S, Gallardo, Juan Pablo, Niborski, Leticia L, Rodríguez-Durán, Jessica, Lapadula, Walter J, Juri Ayub, Maximiliano, Chadi, Raúl, Hernandez, Yolanda, Fernandez, Marisa L, Potenza, Mariana, Gómez, Karina A

“…Chagas disease is caused by the parasite . In humans, it evolves into a chronic disease, eventually resulting in cardiac, digestive, and/or neurological…”
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Expression of Inhibitory Receptors TIGIT, TIM-3, and LAG-3 on CD4+ T Cells from Patients with Different Clinical Forms of Chronic Chagas Disease by Ferragut, Fátima, Alcaraz, Paula B, Beati, Paula, Girard, Magali C, Ossowski, Micaela S, Chadi, Raúl, Fernández, Marisa, Hernández-Vásquez, Yolanda, Acevedo, Gonzalo R, Gómez, Karina A

“…T cells are central to the adaptive immune response against Trypanosoma cruzi infection. In chronic Chagas disease (CCD), circulating parasite-specific memory…”
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Ex vivo characterization of Breg cells in patients with chronic Chagas disease by Girard, Magalí C., Acevedo, Gonzalo R., Ossowski, Micaela S., Fernández, Marisa, Hernández, Yolanda, Chadi, Raúl, Gómez, Karina A.

“…Despite the growing importance of the regulatory function of B cells in many infectious diseases, their immunosuppressive role remains elusive in chronic…”
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Galectin-1 Prevents Infection and Damage Induced by Trypanosoma cruzi on Cardiac Cells by Benatar, Alejandro F, García, Gabriela A, Bua, Jacqeline, Cerliani, Juan P, Postan, Miriam, Tasso, Laura M, Scaglione, Jorge, Stupirski, Juan C, Toscano, Marta A, Rabinovich, Gabriel A, Gómez, Karina A

“…Chronic Chagas cardiomyopathy caused by Trypanosoma cruzi is the result of a pathologic process starting during the acute phase of parasite infection. Among…”
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Interaction Between the Angiotensin-(1–7) Mas Receptor and the Dopamine D2 Receptor: Implications in Inflammation by Rukavina Mikusic, Natalia L., Silva, Mauro G., Mazzitelli, Luciana R., Santos, Robson A.S., Gómez, Karina A., Grecco, Hernán E., Gironacci, Mariela M.

“…Ang (angiotensin) 1–7 MasR (Mas receptor) and D2R (dopamine D2 receptor) stimulation is coupled to anti-inflammatory responses. In the present work, we…”
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Alamandine, a protective component of the renin-angiotensin system, reduces cellular proliferation and interleukin-6 secretion in human macrophages through MasR–MrgDR heteromerization by Rukavina Mikusic, Natalia L., Silva, Mauro G., Erra Díaz, Fernando A., Pineda, Angélica M., Ferragut, Fátima, Gómez, Karina A., Mazzitelli, Luciana, Gonzalez Maglio, Daniel H., Nuñez, Myriam, Santos, Robson A.S., Grecco, Hernán E., Gironacci, Mariela M.

“…[Display omitted] Alamandine (ALA) exerts protective effects similar to angiotensin (Ang) (1–7) through Mas-related G protein-coupled receptor type D receptor…”
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Galectin-1 Controls Cardiac Inflammation and Ventricular Remodeling during Acute Myocardial Infarction by Seropian, Ignacio M, Cerliani, Juan P, Toldo, Stefano, Van Tassell, Benjamín W, Ilarregui, Juan M, González, Germán E, Matoso, Mirian, Salloum, Fadi N, Melchior, Ryan, Gelpi, Ricardo J, Stupirski, Juan C, Benatar, Alejandro, Gómez, Karina A, Morales, Celina, Abbate, Antonio, Rabinovich, Gabriel A

“…Galectin-1 (Gal-1), an evolutionarily conserved β-galactoside-binding lectin, plays essential roles in the control of inflammation and neovascularization…”
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In Silico Guided Discovery of Novel Class I and II Trypanosoma cruzi Epitopes Recognized by T Cells from Chagas' Disease Patients by Acevedo, Gonzalo R, Juiz, Natalia A, Ziblat, Andrea, Pérez Perri, Lucas, Girard, Magalí C, Ossowski, Micaela S, Fernández, Marisa, Hernández, Yolanda, Chadi, Raúl, Wittig, Michael, Franke, Andre, Nielsen, Morten, Gómez, Karina A

“…T cell-mediated immune response plays a crucial role in controlling infection and parasite burden, but it is also involved in the clinical onset and…”
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The cytosolic tryparedoxin peroxidase from Trypanosoma cruzi induces a pro‐inflammatory Th1 immune response in a peroxidatic cysteine‐dependent manner by López, Lucía, Chiribao, María Laura, Girard, Magalí C., Gómez, Karina A., Carasi, Paula, Fernandez, Marisa, Hernandez, Yolanda, Robello, Carlos, Freire, Teresa, Piñeyro, María Dolores

“…Summary Trypanosoma cruzi cytosolic tryparedoxin peroxidase (c‐TXNPx) is a 2‐Cys peroxiredoxin (Prx) with an important role in detoxifying host cell oxidative…”
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Trypanosoma cruzi Induces Regulatory B Cell Alterations in Patients With Chronic Chagas Disease by Girard, Magalí C, Ossowski, Micaela S, Muñoz-Calderón, Arturo, Fernández, Marisa, Hernández-Vásquez, Yolanda, Chadi, Raúl, Gómez, Karina A

“…The clinical evolution of patients with chronic Chagas disease (CCD) is mainly associated with an excessive inflammation and a defective immunomodulatory…”
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Methodological approach to the ex vivo expansion and detection of T. cruzi-specific T cells from chronic Chagas disease patients by Acevedo, Gonzalo R, Longhi, Silvia A, Bunying, Alcinette, Sabri, Nazila, Atienza, Augusto, Zago, María P, Santos, Radleigh, Judkowski, Valeria A, Pinilla, Clemencia, Gómez, Karina A

“…The discovery of T cell epitopes is essential not only for gaining knowledge about host response to infectious disease but also for the development of…”
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Evaluation of the immune response against Trypanosoma cruzi cytosolic tryparedoxin peroxidase in human natural infection by Girard, Magalí C., Acevedo, Gonzalo R., López, Lucía, Ossowski, Micaela S., Piñeyro, María D., Grosso, Juan P., Fernandez, Marisa, Hernández Vasquez, Yolanda, Robello, Carlos, Gómez, Karina A.

“…Summary Trypanosoma cruzi, the aetiological agent of Chagas disease, has a highly efficient detoxification system to deal with the oxidative burst imposed by…”
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Recombinant antibody against Trypanosoma cruzi from patients with chronic Chagas heart disease recognizes mammalian nervous system by Niborski, Leticia L., Potenza, Mariana, Chirivi, Renato G.S., Simonetti, Leandro, Ossowski, Micaela S., Grippo, Vanina, May, Maria, Staquicini, Daniela I., Parodi-Talice, Adriana, Robello, Carlos, Comini, Marcelo A., Alonso, Guillermo D., Raats, Jos M.H., Gómez, Karina A.

“…To deeply understand the role of antibodies in the context of Trypanosoma cruzi infection, we decided to characterize A2R1, a parasite antibody selected from…”
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Correction: Methodological approach to the ex vivo expansion and detection of T. cruzi-specific T cells from chronic Chagas disease patients by Acevedo, Gonzalo R, Longhi, Silvia A, Bunying, Alcinette, Sabri, Nazila, Atienza, Augusto, Zago, María P, Santos, Radleigh, Judkowski, Valeria A, Pinilla, Clemencia, Gómez, Karina A

“…[This corrects the article DOI: 10.1371/journal.pone.0178380.]…”
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Serological based monitoring of a cohort of patients with chronic Chagas disease treated with benznidazole in a highly endemic area of northern Argentina by Niborski, Leticia L, Grippo, Vanina, Lafón, Sonia O, Levitus, Gabriela, García-Bournissen, Facundo, Ramirez, Juan C, Burgos, Juan M, Bisio, Margarita, Juiz, Natalia A, Ayala, Vilma, Coppede, María, Herrera, Verónica, López, Crescencia, Contreras, Ana, Gómez, Karina A, Elean, Juan C, Mujica, Hugo D, Schijman, Alejandro G, Levin, Mariano J, Longhi, Silvia A

“…This study aimed to evaluate well-documented diagnostic antigens, named B13, 1F8 and JL7 recombinant proteins, as potential markers of seroconversion in…”
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Antibodies against the Trypanosoma cruzi ribosomal P proteins induce apoptosis in HL-1 cardiac cells by Levy, Gabriela V., Tasso, Laura M., Longhi, Silvia A., Rivello, Hernán García, Kytö, Ville, Saukko, Pekka, Levin, Mariano J., Gómez, Karina A.

“…[Display omitted] ► The monoclonal antibody against the C-terminal end of the Trypanosoma cruzi ribosomal P2 protein (R13 peptide), called mAb 17.2, and its…”
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Crystal structure of the complex mAb 17.2 and the C-terminal region of Trypanosoma cruzi P2β protein: implications in cross-reactivity by Pizarro, Juan Carlos, Boulot, Ginette, Bentley, Graham A, Gómez, Karina A, Hoebeke, Johan, Hontebeyrie, Mireille, Levin, Mariano J, Smulski, Cristian R

“…Patients with Chronic Chagas' Heart Disease possess high levels of antibodies against the carboxyl-terminal end of the ribosomal P2ß protein of Trypanosoma…”
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The Unsolved Jigsaw Puzzle of the Immune Response in Chagas Disease by Acevedo, Gonzalo R, Girard, Magalí C, Gómez, Karina A

“…interacts with the different arms of the innate and adaptive host's immune response in a very complex and flowery manner. The history of host-parasite…”
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T Cell Specificity: A Great Challenge in Chagas Disease by Ferragut, Fátima, Acevedo, Gonzalo R., Gómez, Karina A.

“…The CD4 + and CD8 + T cell immune response against T. cruzi , the parasite causing Chagas disease, are relevant for both parasite control and disease…”
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