Search Results - "Géa, Luiza P"
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The role of macrophage polarization on bipolar disorder: Identifying new therapeutic targets
Published in Australian & New Zealand Journal of Psychiatry (01-07-2016)“…Objective: Bipolar disorder is a chronic, severe and disabling disease; however, its pathophysiology remains poorly understood. Recent evidence has suggested…”
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Book Review Journal Article -
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Effects of lithium on inflammatory and neurotrophic factors after an immune challenge in a lisdexamfetamine animal model of mania
Published in Revista brasileira de psiquiatria (01-10-2019)“…To evaluate whether an animal model of mania induced by lisdexamfetamine dimesylate (LDX) has an inflammatory profile and whether immune activation by…”
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BDNF prevents central oxidative damage in a chronic unpredictable mild stress model: The possible role of PRDX-1 in anhedonic behavior
Published in Behavioural brain research (27-01-2020)“…•Increased BDNF levels, but no oxidative damage in the hippocampus from animal exposed to the CUMS.•Anhedonic rats show PRDX-1 up-regulation and RELA, ASK-1…”
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Anhedonic-like behavior correlates with IFNγ serum levels in a two-hit model of depression
Published in Behavioural brain research (05-11-2019)“…•Male rats were exposed to an LPS-CUMS protocol to better mimic MDD pathophysiology.•LPS/CUMS + exhibited increased IFNγ serum levels.•Higher IFNγ serum levels…”
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The Costs of Coping: Different Strategies to Deal With Social Defeat Stress Might Come With Distinct Immunologic, Neuroplastic, and Oxidative Stress Consequences in Male Wistar Rats
Published in Behavioral neuroscience (01-10-2021)“…The impact of stress on health and well-being is determined by the ability of an individual to cope with challenges imposed by the stressor. Animals exposed to…”
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Journal Article -
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Reduction of hippocampal IL-6 levels in LPS-injected rats following acute exendin-4 treatment
Published in Naunyn-Schmiedeberg's archives of pharmacology (01-07-2020)“…Preclinical evidence on the role of glucagon-like peptide-1 receptor (GLP-1r) agonists in the brain led to an increased interest in repurposing these compounds…”
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Journal Article -
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Attenuated inflammatory response of monocyte-derived macrophage from patients with BD: a preliminary report
Published in International Journal of Bipolar Disorders (01-06-2019)“…Background Innate immune system dysfunction has been recognized as an important element in the pathophysiology of bipolar disorder (BD). We aimed to…”
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Journal Article -
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Cell therapy in the treatment of bipolar mania in an animal model: a proof of concept study
Published in Trends in psychiatry and psychotherapy (01-07-2017)“…The rationale of mesenchymal stem cells (MSCs) as a novel therapeutic approach in certain neurodegenerative diseases is based on their ability to promote…”
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Journal Article