Search Results - "GÜVEN, Ümmü"

New Psychoactive Substance 5-MeO-MiPT In vivo Acute Toxicity and Hystotoxicological Study by Altuncı, Yusuf Ali, Aydoğdu, Melike, Açıkgöz, Eda, Güven, Ümmü, Düzağaç, Fahriye, Atasoy, Aslı, Dağlıoğlu, Nebile, Annette Akgür, Serap

“…The hallucinogenic tryptamine analog 5-methoxy-N-methyl-N-isopropyltryptamine (5-MeO-MiPT) causes social problems worldwide. There are several studies on the…”
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IR spektroskopi kullanılarak in vitro meme kanser kök hücrelerinin araştırılması by GÜLER, Günnur, GÜVEN, Ümmü, AÇIKGÖZ, Eda, ÖKTEM, Gülperi

“…Amaç: Kanser kök hücreleri (KKH), tümör içinde kendi kendilerini yenileme ve diğer hücre tiplerine farklılaşabilme kapasitesi sebebiyle tümörün başlaması,…”
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Enhanced G2/M Arrest, Caspase Related Apoptosis and Reduced E-Cadherin Dependent Intercellular Adhesion by Trabectedin in Prostate Cancer Stem Cells by Acikgoz, Eda, Guven, Ummu, Duzagac, Fahriye, Uslu, Ruchan, Kara, Mikail, Soner, Burak Cem, Oktem, Gulperi

“…Trabectedin (Yondelis, ET-743) is a marine-derived tetrahydroisoquinoline alkaloid. It is originally derived from the Caribbean marine tunicate Ecteinascidia…”
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Targeting SMYD3 to Sensitize Homologous Recombination-Proficient Tumors to PARP-Mediated Synthetic Lethality by Sanese, Paola, Fasano, Candida, Buscemi, Giacomo, Bottino, Cinzia, Corbetta, Silvia, Fabini, Edoardo, Silvestri, Valentina, Valentini, Virginia, Disciglio, Vittoria, Forte, Giovanna, Lepore Signorile, Martina, De Marco, Katia, Bertora, Stefania, Grossi, Valentina, Guven, Ummu, Porta, Natale, Di Maio, Valeria, Manoni, Elisabetta, Giannelli, Gianluigi, Bartolini, Manuela, Del Rio, Alberto, Caretti, Giuseppina, Ottini, Laura, Simone, Cristiano

“…SMYD3 is frequently overexpressed in a wide variety of cancers. Indeed, its inactivation reduces tumor growth in preclinical in vivo animal models. However,…”
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“Double hit” strategy: Removal of sialic acid from the dendritic cell surface and loading with CD44+/CD24-/low cell lysate inhibits tumor growth and metastasis by targeting breast cancer stem cells by Acikgoz, Eda, Duzagac, Fahriye, Guven, Ummu, Yigitturk, Gurkan, Kose, Timur, Oktem, Gulperi

“…[Display omitted] •Gelsolin and WASp in the podosome-like region of DCs are associated with antigen-up.•Sialic acid free DCs pulsed with lysate inhibited…”
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Embryonic microenvironment suppresses YY1 and YY1-related genes in prostate cancer stem cells by Taskiran, Aysegul, Oktem, Gulperi, Demir, Aleyna, Oltulu, Fatih, Ozcinar, Emine, Duzagac, Fahriye, Guven, Ummu, Karakoc, Emre, Cakir, Asli, Ayla, Sule, Guven, Selcuk, Acikgoz, Eda

“…Yin yang 1 (YY1), a transcription factor, plays crucial roles in cell fate specification, differentiation, and pluripotency during embryonic development. It is…”
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Abstract 2591: miR-193b is a novel regulator of Inhibition of Notch signaling by for targeting cancer stem cell and tumor microenvironment by Guven, Ummu, Mokhlis, Hamada Ahmed, Kahraman, Nermin, Ivan, Cristina, Duzagac, Fahriye, Lopez-Berestein, Gabriel, Oktem, Gulperi, Ozpolat, Bulent

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive human cancers with extremely poor survival rates with 6 months of median patient…”
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Abstract 3686: Regulatory role cancer stem cells (CSCs)-derived exosomal miRNAs in ovarian cancer growth and progression by Duzagac, Fahriye, Lopez-Berestein, Gabriel, Kanlikilicer, Pinar, Rodriguez-Aguoya, Cristian, Cardenas-Zuniga, Roberto, Guven, Ummu, Oktem, Gulperi, Ozpolat, Bulent

“…Ovarian cancer (OC) is the most lethal cancer in all of the gynecological cancers.Despite the recent advancements in the treatment of OC, it remains the…”
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Discovery of the 4-aminopiperidine-based compound EM127 for the site-specific covalent inhibition of SMYD3 by Parenti, Marco Daniele, Naldi, Marina, Manoni, Elisabetta, Fabini, Edoardo, Cederfelt, Daniela, Talibov, Vladimir O., Gressani, Valeria, Guven, Ummu, Grossi, Valentina, Fasano, Candida, Sanese, Paola, De Marco, Katia, Shtil, Alexander A., Kurkin, Alexander V., Altieri, Andrea, Danielson, U. Helena, Caretti, Giuseppina, Simone, Cristiano, Varchi, Greta, Bartolini, Manuela, Del Rio, Alberto

“…Recent findings support the hypothesis that inhibition of SMYD3 methyltransferase may be a therapeutic avenue for some of the deadliest cancer types. Herein,…”
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Induced growth inhibition, cell cycle arrest and apoptosis in CD133+/CD44+ prostate cancer stem cells by flavopiridol by SONER, BURAK CEM, AKTUG, HUSEYIN, ACIKGOZ, EDA, DUZAGAC, FAHRIYE, GUVEN, UMMU, AYLA, SULE, CAL, CAG, OKTEM, GULPERI

“…Flavopiridol is a flavone that inhibits several cyclin-dependent kinases and exhibits potent growth-inhibitory activity, apoptosis and G1-phase arrest in a…”
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Ribosome biogenesis mediates antitumor activity of flavopiridol in CD44+/CD24− breast cancer stem cells by Erol, Ayse, Acikgoz, Eda, Guven, Ummu, Duzagac, Fahriye, Turkkani, Ayten, Colcimen, Nese, Oktem, Gulperi

“…Flavopiridol is a synthetically produced flavonoid that potently inhibits the proliferation of human tumor cell lines. Flavopiridol exerts strong antitumor…”
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Ribosome biogenesis mediates antitumor activity of flavopiridol in [CD44.sup.+]/[CD24.sup.-] breast cancer stem cells by Erol, Ayse, Acikgoz, Eda, Guven, Ummu, Duzagac, Fahriye, Turkkani, Ayten, Colcimen, Nese, Oktem, Gulperi

“…Flavopiridol is a synthetically produced flavonoid that potently inhibits the proliferation of human tumor cell lines. Flavopiridol exerts strong antitumor…”
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Repression of the Notch pathway prevents liver damage in streptozotocin-induced diabetic mice by Acikgoz, Eda, Aktug, Huseyin, Yigitturk, Gurkan, Demir, Kenan, Guven, Ummu, Duzagac, Fahriye, Oltulu, Fatih, Yavasoglu, Altug, Oktem, Gulperi

“…Sunitinib is an oral inhibitor of vascular endothelial growth factor that is used to treat a variety of cancer. There are limited data regarding the effect of…”
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Abstract 4072: Wnt1 gene expression alters heterogeneous population of prostate cancer cells; decreased expression pattern observed in CD133+/CD44+prostate cancer stem cells by Goksel, Gamze, Bilir, Ayhan, Uslu, Ruchan, Akbulut, Hakan, Guven, Ummu, Oktem, Gulperi

“…Tumor mass contains a complex and heterogeneous phenotypic population including a rare group of cancer cells that are capable of serving cancer- initiating…”
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Induced growth inhibition, cell cycle arrest and apoptosis in [CD133.sup.+]/[CD44.sup.+] prostate cancer stem cells by flavopiridol by Soner, Burak Cem, Aktug, Huseyin, Acikgoz, Eda, Duzagac, Fahriye, Guven, Ummu, Ayla, Sule, Cal, Cag, Oktem, Gulperi

“…Flavopiridol is a flavone that inhibits several cyclin-dependent kinases and exhibits potent growth-inhibitory activity, apoptosis and [G.sub.1]-phase arrest…”
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WNT1 gene expression alters in heterogeneous population of prostate cancer cells; decreased expression pattern observed in CD133+/CD44+ prostate cancer stem cell spheroids by Goksel, Gamze, Bilir, Ayhan, Uslu, Ruchan, Akbulut, Hakan, Guven, Ummu, Oktem, Gulperi

“…Established cancer cell lines contain cancer stem cells (CSCs) which can propagate to form three dimensional (3D) tumor spheroids in vitro. Aberrant activation…”
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JAK/STAT pathway interacts with intercellular cell adhesion molecule (ICAM) and vascular cell adhesion molecule (VCAM) while prostate cancer stem cells form tumor spheroids by Duzagac, Fahriye, Inan, Sevinc, Ela Simsek, Fatma, Acikgoz, Eda, Guven, Ummu, Khan, Shafiq A, Rouhrazi, Hadi, Oltulu, Fatih, Aktug, Huseyin, Erol, Ayse, Oktem, Gulperi

“…JAK/STAT is an evolutionarily conserved pathway and very important for second messenger system. This pathway is important in malignant transformation and…”
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Enhanced G2/M Arrest, Caspase Related Apoptosis and Reduced E-Cadherin Dependent Intercellular Adhesion by Trabectedin in Prostate Cancer Stem Cells: e0141090 by Acikgoz, Eda, Guven, Ummu, Duzagac, Fahriye, Uslu, Ruchan, Kara, Mikail, Soner, Burak Cem, Oktem, Gulperi

“…Trabectedin (Yondelis, ET-743) is a marine-derived tetrahydroisoquinoline alkaloid. It is originally derived from the Caribbean marine tunicate Ecteinascidia…”
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