Search Results - "GÖHRING, Gudrun"

Clonal evolution patterns in acute myeloid leukemia with NPM1 mutation by Cocciardi, Sibylle, Dolnik, Anna, Kapp-Schwoerer, Silke, Rücker, Frank G., Lux, Susanne, Blätte, Tamara J., Skambraks, Sabrina, Krönke, Jan, Heidel, Florian H., Schnöder, Tina M., Corbacioglu, Andrea, Gaidzik, Verena I., Paschka, Peter, Teleanu, Veronica, Göhring, Gudrun, Thol, Felicitas, Heuser, Michael, Ganser, Arnold, Weber, Daniela, Sträng, Eric, Kestler, Hans A., Döhner, Hartmut, Bullinger, Lars, Döhner, Konstanze

“…Mutations in the nucleophosmin 1 ( NPM1 ) gene are considered founder mutations in the pathogenesis of acute myeloid leukemia (AML). To characterize the…”
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Pulmonary Transplantation of Human Induced Pluripotent Stem Cell-derived Macrophages Ameliorates Pulmonary Alveolar Proteinosis by Happle, Christine, Lachmann, Nico, Ackermann, Mania, Mirenska, Anja, Göhring, Gudrun, Thomay, Kathrin, Mucci, Adele, Hetzel, Miriam, Glomb, Torsten, Suzuki, Takuji, Chalk, Claudia, Glage, Silke, Dittrich-Breiholz, Oliver, Trapnell, Bruce, Moritz, Thomas, Hansen, Gesine

“…Although the transplantation of induced pluripotent stem cell (iPSC)-derived cells harbors enormous potential for the treatment of pulmonary diseases, in vivo…”
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Measurable residual disease monitoring by NGS before allogeneic hematopoietic cell transplantation in AML by Thol, Felicitas, Gabdoulline, Razif, Liebich, Alessandro, Klement, Piroska, Schiller, Johannes, Kandziora, Christian, Hambach, Lothar, Stadler, Michael, Koenecke, Christian, Flintrop, Madita, Pankratz, Mira, Wichmann, Martin, Neziri, Blerina, Büttner, Konstantin, Heida, Bennet, Klesse, Sabrina, Chaturvedi, Anuhar, Kloos, Arnold, Göhring, Gudrun, Schlegelberger, Brigitte, Gaidzik, Verena I., Bullinger, Lars, Fiedler, Walter, Heim, Albert, Hamwi, Iyas, Eder, Matthias, Krauter, Jürgen, Schlenk, Richard F., Paschka, Peter, Döhner, Konstanze, Döhner, Hartmut, Ganser, Arnold, Heuser, Michael

“…Molecular measurable residual disease (MRD) assessment is not established in approximately 60% of acute myeloid leukemia (AML) patients because of the lack of…”
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Generation of non-transgenic iPS cells from human cord blood CD34+ cells under animal component-free conditions by Haase, Alexandra, Göhring, Gudrun, Martin, Ulrich

“…Recently, many hurdles and limitations for production of clinically applicable iPSC derivatives have been overcome. Transgene-free iPSCs can be efficiently…”
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A unique role of p53 haploinsufficiency or loss in the development of acute myeloid leukemia with FLT3-ITD mutation by Yang, Min, Pan, Zengkai, Huang, Kezhi, Büsche, Guntram, Liu, Hongyun, Göhring, Gudrun, Rumpel, Regina, Dittrich-Breiholz, Oliver, Talbot, Steven, Scherr, Michaela, Chaturvedi, Anuhar, Eder, Matthias, Skokowa, Julia, Zhou, Jianfeng, Welte, Karl, von Neuhoff, Nils, Liu, Ligen, Ganser, Arnold, Li, Zhixiong

“…With an incidence of ~50%, the absence or reduced protein level of p53 is much more common than TP53 mutations in acute myeloid leukemia (AML). AML with FLT3…”
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Gene therapy for Wiskott-Aldrich syndrome--long-term efficacy and genotoxicity by Braun, Christian Jörg, Boztug, Kaan, Paruzynski, Anna, Witzel, Maximilian, Schwarzer, Adrian, Rothe, Michael, Modlich, Ute, Beier, Rita, Göhring, Gudrun, Steinemann, Doris, Fronza, Raffaele, Ball, Claudia Regina, Haemmerle, Reinhard, Naundorf, Sonja, Kühlcke, Klaus, Rose, Martina, Fraser, Chris, Mathias, Liesl, Ferrari, Rudolf, Abboud, Miguel R, Al-Herz, Waleed, Kondratenko, Irina, Maródi, László, Glimm, Hanno, Schlegelberger, Brigitte, Schambach, Axel, Albert, Michael Heinrich, Schmidt, Manfred, von Kalle, Christof, Klein, Christoph

“…Wiskott-Aldrich syndrome (WAS) is characterized by microthrombocytopenia, immunodeficiency, autoimmunity, and susceptibility to malignancies. In our…”
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A novel classification of hematologic conditions in patients with Fanconi anemia by Behrens, Yvonne Lisa, Göhring, Gudrun, Bawadi, Randa, Cöktü, Sümeyye, Reimer, Christina, Hoffmann, Beatrice, Sänger, Birte, Käfer, Simon, Thol, Felicitas, Erlacher, Miriam, Niemeyer, Charlotte M, Baumann, Irith, Kalb, Reinhard, Schindler, Detlev, Kratz, Christian Peter

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Knockout of the HMG domain of the porcine SRY gene causes sex reversal in gene-edited pigs by Kurtz, Stefanie, Lucas-Hahn, Andrea, Schlegelberger, Brigitte, Göhring, Gudrun, Niemann, Heiner, Mettenleiter, Thomas C., Petersen, Björn

“…The sex-determining region on the Y chromosome (SRY) is thought to be the central genetic element of male sex development in mammals. Pathogenic modifications…”
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Incidence and Prognostic Influence of DNMT3A Mutations in Acute Myeloid Leukemia by THOL, Felicitas, DAMM, Frederik, LÜBBERT, Michael, KANZ, Lothar, FIEDLER, Walter, KIRCHNER, Hartmut, HEIL, Gerhard, KRAUTER, Jürgen, GANSER, Arnold, HEUSER, Michael, LÜDEKING, Andrea, WINSCHEL, Claudia, WAGNER, Katharina, MORGAN, Michael, HAIYANG YUN, GÖHRING, Gudrun, SCHLEGELBERGER, Brigitte, HOELZER, Dieter

“…To study the incidence and prognostic impact of mutations in DNA methyltransferase 3A (DNMT3A) in patients with acute myeloid leukemia. A total of 489 patients…”
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Relapses and treatment-related events contributed equally to poor prognosis in children with ABL-class fusion positive B-cell acute lymphoblastic leukemia treated according to AIEOP-BFM protocols by Cario, Gunnar, Leoni, Veronica, Conter, Valentino, Attarbaschi, Andishe, Zaliova, Marketa, Sramkova, Lucie, Cazzaniga, Gianni, Fazio, Grazia, Sutton, Rosemary, Elitzur, Sarah, Izraeli, Shai, Lauten, Melchior, Locatelli, Franco, Basso, Giuseppe, Buldini, Barbara, Bergmann, Anke K, Lentes, Jana, Steinemann, Doris, Göhring, Gudrun, Schlegelberger, Brigitte, Haas, Oskar A, Schewe, Denis, Buchmann, Swantje, Moericke, Anja, White, Deborah, Revesz, Tamas, Stanulla, Martin, Mann, Georg, Bodmer, Nicole, Arad-Cohen, Nira, Zuna, Jan, Valsecchi, Maria Grazia, Zimmermann, Martin, Schrappe, Martin, Biondi, Andrea

“…ABL-class fusions other than characterize around 2-3% of precursor B-cell acute lymphoblastic leukemia. Case series indicated that patients suffering from…”
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Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease by Karakaya, Kadin, Ball, Claudia, Ott, Marion G, Seger, Reinhard, Schultze-Strasser, Stephan, Grez, Manuel, Koehl, Ulrike, Preiss, Carolin, Kinner, Andrea, von Kalle, Christof, Stein, Stefan, Schwäble, Joachim, Kühlcke, Klaus, Göhring, Gudrun, Jauch, Anna, Martin, Hans, Schwarzwaelder, Kerstin, Schmidt, Manfred, Yang, Rongxi, Thrasher, Adrian J, Tchatchou, Sandrine, Glimm, Hanno, Krämer, Alwin, Schlegelberger, Brigitte, Reinecke, Petra, Hofmann, Wolf-Karsten, Burwinkel, Barbara, Hoelzer, Dieter

“…Transduced hematopoietic stem cells can benefit patients with X-linked chronic granulomatous disease (a genetic immunodeficiency), but it's not risk free. In…”
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TP53 Mutations in Low-Risk Myelodysplastic Syndromes With del(5q) Predict Disease Progression by JÄDERSTEN, Martin, SAFT, Leonie, HELLSTRÖM-LINDBERG, Eva, MUFTI, Ghulam J, SMITH, Alexander, KULASEKARARAJ, Austin, POMPLUN, Sabine, GÖHRING, Gudrun, HEDLUND, Anette, HAST, Robert, SCHLEGELBERGER, Brigitte, PORWIT, Anna

“…To determine the frequency of TP53 mutations and the level of p53 protein expression by immunohistochemistry (IHC) in low-risk myelodysplastic syndromes (MDS)…”
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IDH1/2 mutations in acute myeloid leukemia patients and risk of coronary artery disease and cardiac dysfunction—a retrospective propensity score analysis by Kattih, Badder, Shirvani, Amir, Klement, Piroska, Garrido, Abel Martin, Gabdoulline, Razif, Liebich, Alessandro, Brandes, Maximilian, Chaturvedi, Anuhar, Seeger, Timon, Thol, Felicitas, Göhring, Gudrun, Schlegelberger, Brigitte, Geffers, Robert, John, David, Bavendiek, Udo, Bauersachs, Johann, Ganser, Arnold, Heineke, Joerg, Heuser, Michael

“…Clonal hematopoiesis of indeterminate potential (CHIP) is linked to leukemia gene mutations and associates with an increased risk for coronary artery disease…”
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Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells by Kempf, Henning, Olmer, Ruth, Haase, Alexandra, Franke, Annika, Bolesani, Emiliano, Schwanke, Kristin, Robles-Diaz, Diana, Coffee, Michelle, Göhring, Gudrun, Dräger, Gerald, Pötz, Oliver, Joos, Thomas, Martinez-Hackert, Erik, Haverich, Axel, Buettner, Falk F. R., Martin, Ulrich, Zweigerdt, Robert

“…In vitro differentiation of human pluripotent stem cells (hPSCs) recapitulates early aspects of human embryogenesis, but the underlying processes are poorly…”
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Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia by Krönke, Jan, Bullinger, Lars, Teleanu, Veronica, Tschürtz, Florian, Gaidzik, Verena I., Kühn, Michael W.M., Rücker, Frank G., Holzmann, Karlheinz, Paschka, Peter, Kapp-Schwörer, Silke, Späth, Daniela, Kindler, Thomas, Schittenhelm, Marcus, Krauter, Jürgen, Ganser, Arnold, Göhring, Gudrun, Schlegelberger, Brigitte, Schlenk, Richard F., Döhner, Hartmut, Döhner, Konstanze

“…Mutations in the nucleophosmin 1 (NPM1) gene are considered a founder event in the pathogenesis of acute myeloid leukemia (AML). To address the role of clonal…”
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Reduced-Intensity Delayed Intensification in Standard-Risk Pediatric Acute Lymphoblastic Leukemia Defined by Undetectable Minimal Residual Disease: Results of an International Randomized Trial (AIEOP-BFM ALL 2000) by Schrappe, Martin, Bleckmann, Kirsten, Zimmermann, Martin, Biondi, Andrea, Möricke, Anja, Locatelli, Franco, Cario, Gunnar, Rizzari, Carmelo, Attarbaschi, Andishe, Valsecchi, Maria Grazia, Bartram, Claus R, Barisone, Elena, Niggli, Felix, Niemeyer, Charlotte, Testi, Anna Maria, Mann, Georg, Ziino, Ottavio, Schäfer, Beat, Panzer-Grümayer, Renate, Beier, Rita, Parasole, Rosanna, Göhring, Gudrun, Ludwig, Wolf-Dieter, Casale, Fiorina, Schlegel, Paul-Gerhardt, Basso, Giuseppe, Conter, Valentino

“…Purpose Delayed intensification (DI) is an integral part of treatment of childhood acute lymphoblastic leukemia (ALL), but it is associated with relevant…”
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Mutations in the cohesin complex in acute myeloid leukemia: clinical and prognostic implications by Thol, Felicitas, Bollin, Robin, Gehlhaar, Marten, Walter, Carolin, Dugas, Martin, Suchanek, Karl Josef, Kirchner, Aylin, Huang, Liu, Chaturvedi, Anuhar, Wichmann, Martin, Wiehlmann, Lutz, Shahswar, Rabia, Damm, Frederik, Göhring, Gudrun, Schlegelberger, Brigitte, Schlenk, Richard, Döhner, Konstanze, Döhner, Hartmut, Krauter, Jürgen, Ganser, Arnold, Heuser, Michael

“…Mutations in the cohesin complex are novel, genetic lesions in acute myeloid leukemia (AML) that are not well characterized. In this study, we analyzed the…”
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CRISPR-Cas9-induced t(11;19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells in vivo by Reimer, Jana, Knöß, Sabine, Labuhn, Maurice, Charpentier, Emmanuelle M, Göhring, Gudrun, Schlegelberger, Brigitte, Klusmann, Jan-Henning, Heckl, Dirk

“…Chromosomal translocations that generate oncogenic fusion proteins are causative for most pediatric leukemias and frequently affect the gene. modeling of…”
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Prognostic Significance of ASXL1 Mutations in Patients With Myelodysplastic Syndromes by THOL, Felicitas, FRIESEN, Inna, GÖHRING, Gudrun, SCHUMANN, Christiane, BUG, Gesine, OTTMANN, Oliver, HOFMANN, Wolf-Karsten, SCHLEGELBERGER, Brigitte, HEUSER, Michael, GANSER, Arnold, DAMM, Frederik, YUN, Haiyang, WEISSINGER, Eva M, KRAUTER, Jürgen, WAGNER, Katharina, CHATURVEDI, Anuhar, SHARMA, Amit, WICHMANN, Martin

“…To study the incidence and prognostic impact of mutations in Additional sex comb-like 1 (ASXL1) in a large cohort of patients with myelodysplastic syndrome…”
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Monitoring of Minimal Residual Disease in NPM1-Mutated Acute Myeloid Leukemia: A Study From the German-Austrian Acute Myeloid Leukemia Study Group by KRÖNKE, Jan, SCHLENK, Richard F, SPÄTH, Daniela, LÜBBERT, Michael, WATTAD, Mohammed, KINDLER, Thomas, SALIH, Helmut R, HELD, Gerhard, NACHBAUR, David, VON LILIENFELD-TOAL, Marie, GERMING, Ulrich, HAASE, Detlef, JENSEN, Kai-Ole, MERGENTHALER, Hans-Günther, KRAUTER, Jürgen, GANSER, Arnold, GÖHRING, Gudrun, SCHLEGELBERGER, Brigitte, DÖHNER, Hartmut, DÖHNER, Konstanze, TSCHÜRTZ, Florian, CORBACIOGLU, Andrea, GAIDZIK, Verena I, PASCHKA, Peter, ONKEN, Shiva, EIWEN, Karina, HABDANK, Marianne

“…To evaluate the prognostic value of minimal residual disease (MRD) in patients with acute myeloid leukemia (AML) with NPM1 mutation (NPM1(mut)). RNA-based…”
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