Search Results - "G, Palmer"

Chemical exchange in biomacromolecules: Past, present, and future by Palmer, Arthur G.

“…[Display omitted] •Chemical exchange methods for application to biomacromolecules are reviewed.•A unified description of spin-locking experiments from weak to…”
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Non-native plants add to the British flora without negative consequences for native diversity by Thomas, Chris D., Palmer, G.

“…Significance Non-native plants dominate global lists of invasive (harmful) species, yet plants introduced to Britain are both less widespread than native…”
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Integrated control of Na transport along the nephron by Palmer, Lawrence G, Schnermann, Jürgen

“…The kidney filters vast quantities of Na at the glomerulus but excretes a very small fraction of this Na in the final urine. Although almost every nephron…”
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NMR Characterization of the Dynamics of Biomacromolecules by Palmer, Arthur G

“…Palmer describes the principal applications of spin relaxation methods for investigating conformational dynamic processes in proteins and nucleic acids. He…”
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Directing two-way traffic in the kidney: A tale of two ions by Palmer, Lawrence G

“…The kidneys regulate levels of Na+ and K+ in the body by varying urinary excretion of the electrolytes. Since transport of each of the two ions can affect the…”
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Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes by Herrero, Ana, Pinto, Adán, Colón-Bolea, Paula, Casar, Berta, Jones, Mary, Agudo-Ibáñez, Lorena, Vidal, Rebeca, Tenbaum, Stephan P., Nuciforo, Paolo, Valdizán, Elsa M., Horvath, Zoltan, Orfi, Laszlo, Pineda-Lucena, Antonio, Bony, Emilie, Keri, Gyorgy, Rivas, Germán, Pazos, Angel, Gozalbes, Rafael, Palmer, Héctor G., Hurlstone, Adam, Crespo, Piero

“…Nearly 50% of human malignancies exhibit unregulated RAS-ERK signaling; inhibiting it is a valid strategy for antineoplastic intervention. Upon activation, ERK…”
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Enzyme Dynamics from NMR Spectroscopy by Palmer, Arthur G.

“…Biological activities of enzymes, including regulation or coordination of mechanistic stages preceding or following the chemical step, may depend upon kinetic…”
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Breaking down walls: Continuous potential models for internal motions in NMR spin relaxation by Palmer, Arthur G.

“…Simple physical models for restricted diffusion in a potential, which provide important insights for NMR spin relaxation, usually are based on free diffusion…”
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Clinical Exome Sequencing for Genetic Identification of Rare Mendelian Disorders by Lee, Hane, Deignan, Joshua L, Dorrani, Naghmeh, Strom, Samuel P, Kantarci, Sibel, Quintero-Rivera, Fabiola, Das, Kingshuk, Toy, Traci, Harry, Bret, Yourshaw, Michael, Fox, Michelle, Fogel, Brent L, Martinez-Agosto, Julian A, Wong, Derek A, Chang, Vivian Y, Shieh, Perry B, Palmer, Christina G. S, Dipple, Katrina M, Grody, Wayne W, Vilain, Eric, Nelson, Stanley F

“…IMPORTANCE: Clinical exome sequencing (CES) is rapidly becoming a common molecular diagnostic test for individuals with rare genetic disorders. OBJECTIVE: To…”
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Colorectal Cancer Consensus Molecular Subtypes Translated to Preclinical Models Uncover Potentially Targetable Cancer Cell Dependencies by Sveen, Anita, Bruun, Jarle, Eide, Peter W, Eilertsen, Ina A, Ramirez, Lorena, Murumägi, Astrid, Arjama, Mariliina, Danielsen, Stine A, Kryeziu, Kushtrim, Elez, Elena, Tabernero, Josep, Guinney, Justin, Palmer, Hector G, Nesbakken, Arild, Kallioniemi, Olli, Dienstmann, Rodrigo, Lothe, Ragnhild A

“…Response to standard oncologic treatment is limited in colorectal cancer. The gene expression-based consensus molecular subtypes (CMS) provide a new paradigm…”
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Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective by Kaplan, Anna, Gaschler, Michael M., Dunn, Denise E., Colligan, Ryan, Brown, Lewis M., Palmer, Arthur G., Lo, Donald C., Stockwell, Brent R.

“…Protein disulfide isomerase (PDI) is a chaperone protein in the endoplasmic reticulum that is up-regulated in mouse models of, and brains of patients with,…”
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Characterization of the Dynamics of Biomacromolecules Using Rotating-Frame Spin Relaxation NMR Spectroscopy by Palmer, Arthur G, Massi, Francesca

“…The purpose of this review is to provide a comprehensive description of theory, techniques, and applications of R1 rho measurements to biobarcromolecules…”
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Interrogating open issues in cancer precision medicine with patient-derived xenografts by Byrne, Annette T., Alférez, Denis G., Amant, Frédéric, Annibali, Daniela, Arribas, Joaquín, Biankin, Andrew V., Bruna, Alejandra, Budinská, Eva, Caldas, Carlos, Chang, David K., Clarke, Robert B., Clevers, Hans, Coukos, George, Dangles-Marie, Virginie, Eckhardt, S. Gail, Gonzalez-Suarez, Eva, Hermans, Els, Hidalgo, Manuel, Jarzabek, Monika A., de Jong, Steven, Jonkers, Jos, Kemper, Kristel, Lanfrancone, Luisa, Mælandsmo, Gunhild Mari, Marangoni, Elisabetta, Marine, Jean-Christophe, Medico, Enzo, Norum, Jens Henrik, Palmer, Héctor G., Peeper, Daniel S., Pelicci, Pier Giuseppe, Piris-Gimenez, Alejandro, Roman-Roman, Sergio, Rueda, Oscar M., Seoane, Joan, Serra, Violeta, Soucek, Laura, Vanhecke, Dominique, Villanueva, Alberto, Vinolo, Emilie, Bertotti, Andrea, Trusolino, Livio

“…This Opinion article discusses progress and challenges in using patient-derived xenograft (PDX) models in cancer precision medicine. It is primarily…”
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Interpreting Protein Structural Dynamics from NMR Chemical Shifts by Robustelli, Paul, Stafford, Kate A, Palmer, Arthur G

“…In this investigation, semiempirical NMR chemical shift prediction methods are used to evaluate the dynamically averaged values of backbone chemical shifts…”
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Dynamics of GCN4 facilitate DNA interaction: a model-free analysis of an intrinsically disordered region by Gill, Michelle L, Byrd, R Andrew, Palmer, III, Arthur G

“…Intrinsically disordered proteins (IDPs) and proteins with intrinsically disordered regions (IDRs) are known to play important roles in regulatory and…”
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β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer by Tenbaum, Stephan P, Ordóñez-Morán, Paloma, Puig, Isabel, Chicote, Irene, Arqués, Oriol, Landolfi, Stefania, Fernández, Yolanda, Herance, José Raúl, Gispert, Juan D, Mendizabal, Leire, Aguilar, Susana, Cajal, Santiago Ramón y, Schwartz, Simó, Vivancos, Ana, Espín, Eloy, Rojas, Santiago, Baselga, José, Tabernero, Josep, Muñoz, Alberto, Palmer, Héctor G

“…The crosstalk between the transcriptional activity of β-catenin and FOXO3a reveals unexpected pro-metastatic cooperative effects of these pathways through…”
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Effects of dietary K on cell-surface expression of renal ion channels and transporters by Frindt, Gustavo, Palmer, Lawrence G

“…Changes in apical surface expression of ion channels and transporters in the superficial rat renal cortex were assessed using biotinylation and immunoblotting…”
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Population‐based study of surgical treatment with and without tumour resection in patients with locally recurrent rectal cancer by Westberg, K., Palmer, G., Hjern, F., Holm, T., Martling, A.

“…Background Population‐based studies of treatment of locally recurrent rectal cancer (LRRC) are lacking. The aim was to investigate the surgical treatment of…”
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Seven Centuries of Reconstructed Brahmaputra River Discharge Demonstrate Underestimated High Discharge and Flood Hazard Frequency by Rao, Mukund P, Cook, Edward R, Cook, Benjamin I, Arrigo, Rosanne D D', Palmer, Jonathan G, Lall, Upmanu, Woodhouse, Connie A, Buckley, Brendan M, Uriarte, Maria, Bishop, Daniel A, Jian, Jun, Webster, Peter J

“…The lower Brahmaputra River in Bangladesh and Northeast India often floods during the monsoon season, with catastrophic consequences for people throughout the…”
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Mechanism of E-cadherin dimerization probed by NMR relaxation dispersion by Li, Ying, Altorelli, Nicole L., Bahna, Fabiana, Honig, Barry, Shapiro, Lawrence, Palmer, Arthur G.

“…Epithelial cadherin (E-cadherin), a member of the classical cadherin family, mediates calcium-dependent homophilic cell–cell adhesion. Crystal structures of…”
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