Regression of morphological alterations and oxidative stress-related parameters after acute lindane-induced hepatotoxicity in rats

Changes in rat liver oxidative stress-related parameters, morphological alterations, as well as circulating and tissue levels of lindane were studied 1–7 days after the administration of a single dose of 60 mg of lindane/kg. One day after lindane treatment, a significant enhancement in the oxidative...

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Published in:	Toxicology (Amsterdam) Vol. 117; no. 2; pp. 199 - 205
Main Authors:	Junqueira, Virginia B.C., Koch, Osvaldo R., Arisi, Ana Carolina M., Fuzaro, Ana Paula, Azzalis, Ligia A., Barros, Silvia B.M., Cravero, Amerys, Farré, Stella, Videla, Luis A.
Format:	Journal Article
Language:	English
Published:	Shannon Elsevier Ireland Ltd 28-02-1997 Amsterdam Elsevier Science
Subjects:	Adipose Tissue - chemistry Animals Biological and medical sciences Catalase - drug effects Catalase - metabolism Hexachlorocyclohexane - blood Hexachlorocyclohexane - pharmacokinetics Hexachlorocyclohexane - toxicity In Vitro Techniques Lindane Liver - drug effects Liver - metabolism Liver - pathology Liver morphological alterations Male Medical sciences Microscopy, Electron Mitochondria - ultrastructure Organelles - ultrastructure Oxidative stress Oxidative Stress - drug effects Pesticides, fertilizers and other agrochemicals toxicology Rats Rats, Wistar Regression Superoxide Dismutase - drug effects Superoxide Dismutase - metabolism Thiobarbituric Acid Reactive Substances - metabolism Tissue Distribution Toxicology Liver morphological alterations Regression Oxidative stress Lindane Intraperitoneal administration Insecticide Rat Toxicity Rodentia Pesticides Hepatic disease Time response relation Free radical Vertebrata Hyperoxides Mammalia Organochlorine compounds Ultrastructure Animal Digestive diseases Reversibility Mechanism of action
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Summary:	Changes in rat liver oxidative stress-related parameters, morphological alterations, as well as circulating and tissue levels of lindane were studied 1–7 days after the administration of a single dose of 60 mg of lindane/kg. One day after lindane treatment, a significant enhancement in the oxidative stress status of the liver was observed, characterized by an increase in thiobarbituric acid reactants production and in the microsomal generation of superoxide radical (O 2 .−) coupled to cytochrome P450 induction, and a decrement in the activity of superoxide dismutase (SOD) and catalase. Consequently, the O 2 .− production/SOD activity ratio was enhanced two-fold. In this condition, light microscopy studies revealed the incidence of liver lesions in periportal areas, together with significant changes at the mitochondrial] level observed by electron microscopy, which coincide with the maximal levels of lindane in the liver, adipose tissue, plasma and whole blood. Changes in oxidative stress-related parameters observed after 1 day of lindane treatment regressed to normal from the third day and thereafter, together with the decrement in circulating and tissue levels of the insecticide. It is concluded that morphological and oxidative stress-related changes induced in the liver by acute lindane intoxication are readily reversible, depend on the hepatic content of the insecticide, and seem to be conditioned by the changes in O 2 − generation.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0300-483X 1879-3185
DOI:	10.1016/S0300-483X(96)03580-9