Search Results - "Futosi, Krisztina"

Tyrosine kinase signaling pathways in neutrophils by Futosi, Krisztina, Mócsai, Attila

“…Summary Neutrophils play a critical role in antimicrobial host defense, but their improper activation also contributes to inflammation‐induced tissue damage…”
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Neutrophil-specific deletion of the CARD9 gene expression regulator suppresses autoantibody-induced inflammation in vivo by Németh, Tamás, Futosi, Krisztina, Sitaru, Cassian, Ruland, Jürgen, Mócsai, Attila

“…Neutrophils are terminally differentiated cells with limited transcriptional activity. The biological function of their gene expression changes is poorly…”
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The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment by Kovács, Miklós, Németh, Tamás, Jakus, Zoltán, Sitaru, Cassian, Simon, Edina, Futosi, Krisztina, Botz, Bálint, Helyes, Zsuzsanna, Lowell, Clifford A, Mócsai, Attila

“…Although Src family kinases participate in leukocyte function in vitro, such as integrin signal transduction, their role in inflammation in vivo is poorly…”
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Dasatinib inhibits proinflammatory functions of mature human neutrophils by Futosi, Krisztina, Németh, Tamás, Pick, Robert, Vántus, Tibor, Walzog, Barbara, Mócsai, Attila

“…Dasatinib is a tyrosine kinase inhibitor used to treat imatinib-resistant chronic myeloid leukemia and Philadelphia chromosome–positive acute lymphoblastic…”
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Analysis of intracellular tyrosine phosphorylation in circulating neutrophils as a rapid assay for the in vivo effect of oral tyrosine kinase inhibitors by Futosi, Krisztina, Bajza, Boglárka, Deli, Dorottya, Erdélyi, András, Tusnády, Simon, Mócsai, Attila

“…Tyrosine kinases are crucial signaling components of diverse biological processes and are major therapeutic targets in various malignancies and immune-mediated…”
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Importance of Fc Receptor γ-Chain ITAM Tyrosines in Neutrophil Activation and in vivo Autoimmune Arthritis by Németh, Tamás, Futosi, Krisztina, Szabó, Marcell, Aradi, Petra, Saito, Takashi, Mócsai, Attila, Jakus, Zoltán

“…Activating Fcγ receptors associated with Fc receptor γ-chain (FcRγ) are critical for mediating neutrophil effector functions in immune complex-mediated…”
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Lineage-Specific Analysis of Syk Function in Autoantibody-Induced Arthritis by Németh, Tamás, Futosi, Krisztina, Szilveszter, Kata, Vilinovszki, Olivér, Kiss-Pápai, Levente, Mócsai, Attila

“…Autoantibody production and autoantibody-mediated inflammation are hallmarks of a number of autoimmune diseases. The K/BxN serum-transfer arthritis is one of…”
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MASP-1 induces a unique cytokine pattern in endothelial cells: a novel link between complement system and neutrophil granulocytes by Jani, Péter K, Kajdácsi, Erika, Megyeri, Márton, Dobó, József, Doleschall, Zoltán, Futosi, Krisztina, Tímár, Csaba I, Mócsai, Attila, Makó, Veronika, Gál, Péter, Cervenak, László

“…Microbial infection urges prompt intervention by the immune system. The complement cascade and neutrophil granulocytes are the predominant contributors to this…”
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Correction: Targeting Vascular Endothelial Growth Factor Receptor 2 and Protein Kinase D1 Related Pathways by a Multiple Kinase Inhibitor in Angiogenesis and Inflammation Related Processes In Vitro by Varga, Attila, Gyulavári, Pál, Greff, Zoltán, Futosi, Krisztina, Németh, Tamás, Simon-Szabó, Laura, Kerekes, Krisztina, Szántai-Kis, Csaba, Brauswetter, Diána, Kokas, Márton, Borbély, Gábor, Erdei, Anna, Mócsai, Attila, Kéri, György, Vántus, Tibor

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Targeting vascular endothelial growth factor receptor 2 and protein kinase D1 related pathways by a multiple kinase inhibitor in angiogenesis and inflammation related processes in vitro by Varga, Attila, Gyulavári, Pál, Greff, Zoltán, Futosi, Krisztina, Németh, Tamás, Simon-Szabó, Laura, Kerekes, Krisztina, Szántai-Kis, Csaba, Brauswetter, Diána, Kokas, Márton, Borbély, Gábor, Erdei, Anna, Mócsai, Attila, Kéri, György, Vántus, Tibor

“…Emerging evidence suggests that the vascular endothelial growth factor receptor 2 (VEGFR2) and protein kinase D1 (PKD1) signaling axis plays a critical role in…”
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Neutrophil functions and autoimmune arthritis in the absence of p190RhoGAP: generation and analysis of a novel null mutation in mice by Németh, Tamás, Futosi, Krisztina, Hably, Csilla, Brouns, Madeleine R, Jakob, Sascha M, Kovács, Miklós, Kertész, Zsuzsanna, Walzog, Barbara, Settleman, Jeffrey, Mócsai, Attila

“…Beta(2) integrins of neutrophils play a critical role in innate immune defense, but they also participate in tissue destruction during autoimmune inflammation…”
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Neutrophil cell surface receptors and their intracellular signal transduction pathways by Futosi, Krisztina, Fodor, Szabina, Mócsai, Attila

“…Neutrophils play a critical role in the host defense against bacterial and fungal infections, but their inappropriate activation also contributes to tissue…”
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Antimigratory and antimetastatic effect of heparin-derived 4-18 unit oligosaccharides in a preclinical human melanoma metastasis model by Kenessey, István, Simon, Erika, Futosi, Krisztina, Bereczky, Bíborka, Kiss, Andrea, Erdödi, Ferenc, Gallagher, John T, Tímár, József, Tóvári, József

“…Heparin and its derivatives have been shown to inhibit angiogenesis and metastasis formation. Accordingly, we investigated the effect of heparin fragments…”
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Neutrophil IL-26 fuels autoinflammation by Futosi, Krisztina, Mócsai, Attila

“…Pustular psoriasis is an inflammatory skin disease with features of neutrophil-mediated sterile autoinflammation. In this issue of JEM, Baldo et al…”
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Reprint of Neutrophil cell surface receptors and their intracellular signal transduction pathways by Futosi, Krisztina, Fodor, Szabina, Mócsai, Attila

“…Neutrophils play a critical role in the host defense against bacterial and fungal infections, but their inappropriate activation also contributes to tissue…”
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Neutrophil Phospholipase Cγ2 Drives Autoantibody‐Induced Arthritis Through the Generation of the Inflammatory Microenvironment by Futosi, Krisztina, Kása, Orsolya, Szilveszter, Kata P., Mócsai, Attila

“…Objective Gain‐of‐function mutations and genome‐wide association studies have linked phospholipase Cγ2 (PLCγ2) to various inflammatory diseases, including…”
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Myeloid Src-family kinases are critical for neutrophil-mediated autoinflammation in gout and motheaten models by Futosi, Krisztina, Németh, Tamás, Horváth, Ádám I, Abram, Clare L, Tusnády, Simon, Lowell, Clifford A, Helyes, Zsuzsanna, Mócsai, Attila

“…Autoinflammatory diseases include a number of monogenic systemic inflammatory diseases, as well as acquired autoinflammatory diseases such as gout. Here, we…”
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Boyden chamber-based method for characterizing the distribution of adhesions and cytoskeletal structure in HT1080 fibrosarcoma cells by Tóvári, József, Futosi, Krisztina, Bartal, Alexandra, Tátrai, Enikő, Gacs, Alexandra, Kenessey, István, Paku, Sándor

“…A 2D model was previously presented that describes the gliding motility of human fibrosarcoma cells. The model was based on the observation that adhesions are…”
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MASP-1 Induces a Unique Cytokine Pattern in Endothelial Cells: A Novel Link between Complement System and Neutrophil Granulocytes: e87104 by Jani, Peter K, Kajdacsi, Erika, Megyeri, Marton, Dobo, Jozsef, Doleschall, Zoltan, Futosi, Krisztina, Timar, Csaba I, Mocsai, Attila, Mako, Veronika, Gal, Peter

“…Microbial infection urges prompt intervention by the immune system. The complement cascade and neutrophil granulocytes are the predominant contributors to this…”
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Optimization of important early ADME(T) parameters of NADPH oxidase-4 inhibitor molecules by Borbély, Gábor, Huszár, Ménika, Varga, Attila, Futosi, Krisztina, Mócsai, Attila, Orfi, László, Idei, Miklós, Mandl, József, Kéri, György, Vántus, Tibor

“…Through their reactive oxygen species (ROS) producing function, NADPH oxidase (NOX) enzymes have been linked to several oxidative stress related diseases. In…”
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