Search Results - "Futoshi Nara"

Neuromuscular stimulation ameliorates ischemia-induced walking impairment in the rat claudication model by Shiragaki-Ogitani, Momoko, Kono, Keita, Nara, Futoshi, Aoyagi, Atsushi

“…Intermittent claudication (IC) is the most common symptom of peripheral arterial disease which significantly deteriorates the quality of life of patients…”
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Discovery and pharmacological effects of a novel GPR142 antagonist by Murakoshi, Michiko, Kuwabara, Harumi, Nagasaki, Miyuki, Xiong, Yu Mei, Reagan, Jeff D., Maeda, Hiroaki, Nara, Futoshi

“…GPR142 is a G-protein-coupled receptor (GPCR), whose most potent and efficacious ligand has been reported as being the natural amino acid l-tryptophan. GPR142…”
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Discovery and optimization of a novel series of GPR142 agonists for the treatment of type 2 diabetes mellitus by Lizarzaburu, Mike, Turcotte, Simon, Du, Xiaohui, Duquette, Jason, Fu, Angela, Houze, Jonathan, Li, Leping, Liu, Jinqian, Murakoshi, Michiko, Oda, Kozo, Okuyama, Ryo, Nara, Futoshi, Reagan, Jeff, Yu, Ming, Medina, Julio C.

“…The discovery and initial optimization of a series of phenylalanine based agonists for GPR142 is described. The structure-activity-relationship around the…”
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Novel Keap1-Nrf2 Protein-Protein Interaction Inhibitor UBE-1099 Ameliorates Progressive Phenotype in Alport Syndrome Mouse Model by Kaseda, Shota, Sannomiya, Yuya, Horizono, Jun, Kuwazuru, Jun, Suico, Mary Ann, Ogi, Sayaka, Sasaki, Ryoko, Sunamoto, Hidetoshi, Fukiya, Hirohiko, Nishiyama, Hayato, Kamura, Misato, Niinou, Saki, Koyama, Yuimi, Nara, Futoshi, Shuto, Tsuyoshi, Onuma, Kazuhiro, Kai, Hirofumi

“…BackgroundBardoxolone methyl activates nuclear factor erythroid 2-related factor 2 (Nrf2) via covalent binding and irreversible inhibition of Kelch-like…”
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Efficacy of Keap1-Nrf2 protein-protein interaction inhibitor for progressive phenotype in Alport syndrome mouse model by Shota Kaseda, Yuya Sannomiya, Jun Horizono, Jun Kuwazuru, Mary Ann Suico, Sayaka Ogi, Ryoko Sasaki, Hidetoshi Sunamoto, Hirohiko Fukiya, Hayato Nishiyama, Misato Kamura, Saki Niinou, Yuimi Koyama, Futoshi Nara, Tsuyoshi Shuto, Kazuhiro Onuma, Hirofumi Kai

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Identification of metals from osteoblastic ST-2 cell supernatants as novel OGR1 agonists by Abe-Ohya, Rie, Ishikawa, Tomio, Shiozawa, Hideyuki, Suda, Koji, Nara, Futoshi

“…Ovarian cancer G-protein-coupled receptor 1 (OGR1) is a G-protein-coupled receptor (GPCR), which has previously been identified as a receptor for protons. It…”
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MRGD, a MAS-related G-protein coupled receptor, promotes tumorigenisis and is highly expressed in lung cancer by Nishimura, Satoko, Uno, Makiko, Kaneta, Yasuyuki, Fukuchi, Keisuke, Nishigohri, Haruyuki, Hasegawa, Jun, Komori, Hironobu, Takeda, Shigeki, Enomoto, Katsuhiko, Nara, Futoshi, Agatsuma, Toshinori

“…To elucidate the function of MAS-related GPCR, member D (MRGD) in cancers, we investigated the in vitro and in vivo oncogenic function of MRGD using murine…”
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Purification and Identification of Activating Enzymes of CS-0777, a Selective Sphingosine 1-Phosphate Receptor 1 Modulator, in Erythrocytes by Yonesu, Kiyoaki, Kubota, Kazuishi, Tamura, Masakazu, Inaba, Shin-ichi, Honda, Tomohiro, Yahara, Chizuko, Watanabe, Nobuaki, Matsuoka, Tatsuji, Nara, Futoshi

“…CS-0777 is a selective sphingosine 1-phosphate (S1P) receptor 1 modulator with potential benefits in the treatment of autoimmune diseases, including multiple…”
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Novel CC chemokine receptor 4 antagonist RS-1154 inhibits ovalbumin-induced ear swelling in mice by Nakagami, Yasuhiro, Kawashima, Kayo, Yonekubo, Kazuki, Etori, Maki, Jojima, Takaaki, Miyazaki, Shojiro, Sawamura, Ryoko, Hirahara, Kazuki, Nara, Futoshi, Yamashita, Makoto

“…CC chemokine ligand 17 (CCL17/thymus and activation-regulated chemokine: TARC) and CCL22 (macrophage-derived chemokine: MDC) selectively bind to CC chemokine…”
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Identification of Physiologically Active Substances as Novel Ligands for MRGPRD by Uno, Makiko, Nishimura, Satoko, Fukuchi, Keisuke, Kaneta, Yasuyuki, Oda, Yoko, Komori, Hironobu, Takeda, Shigeki, Haga, Tatsuya, Agatsuma, Toshinori, Nara, Futoshi

“…Mas-related G-protein coupled receptor member D (MRGPRD) is a G protein-coupled receptor (GPCR) which belongs to the Mas-related GPCRs expressed in the dorsal…”
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Discovery of CS-2100, a potent, orally active and S1P3-sparing S1P1 agonist by Nakamura, Tsuyoshi, Asano, Masayoshi, Sekiguchi, Yukiko, Mizuno, Yumiko, Tamaki, Kazuhiko, Kimura, Takako, Nara, Futoshi, Kawase, Yumi, Shimozato, Takaichi, Doi, Hiromi, Kagari, Takashi, Tomisato, Wataru, Inoue, Ryotaku, Nagasaki, Miyuki, Yuita, Hiroshi, Oguchi-Oshima, Keiko, Kaneko, Reina, Watanabe, Nobuaki, Abe, Yasuyuki, Nishi, Takahide

“…A description of the discovery process of CS-2100, a potent, orally active, S1P3-sparing S1P1 agonist has been provided. Its 4-ethyl thiophene structure…”
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Potent and Orally Bioavailable GPR142 Agonists as Novel Insulin Secretagogues for the Treatment of Type 2 Diabetes by Toda, Narihiro, Hao, Xiaolin, Ogawa, Yasuyuki, Oda, Kozo, Yu, Ming, Fu, Zice, Chen, Yi, Kim, Yongjae, Lizarzaburu, Mike, Lively, Sarah, Lawlis, Shauna, Murakoshi, Michiko, Nara, Futoshi, Watanabe, Nobuaki, Reagan, Jeff D, Tian, Hui, Fu, Angela, Motani, Alykhan, Liu, Qingxiang, Lin, Yi-Jyun, Zhuang, Run, Xiong, Yumei, Fan, Peter, Medina, Julio, Li, Leping, Izumi, Masanori, Okuyama, Ryo, Shibuya, Satoshi

“…GPR142 is a G protein-coupled receptor that is predominantly expressed in pancreatic β-cells. GPR142 agonists stimulate insulin secretion in the presence of…”
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RS-1748, a Novel CC Chemokine Receptor 4 Antagonist, Inhibits Ovalbumin-Induced Airway Inflammation in Guinea Pigs by Nakagami, Yasuhiro, Kawase, Yumi, Yonekubo, Kazuki, Nosaka, Emi, Etori, Maki, Takahashi, Sakiko, Takagi, Nana, Fukuda, Takeshi, Kuribayashi, Takeshi, Nara, Futoshi, Yamashita, Makoto

“…CC chemokine receptor 4 (CCR4) is generally recognized as a preferential marker for T helper 2 cells, and we have previously reported morpholine-derivative…”
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EX-10. Efficacy of Keap1-Nrf2 protein-protein interaction inhibitor for progressive phenotype in Alport syndrome mouse model by Shota Kaseda, Yuya Sannomiya, Jun Horizono, Jun Kuwazuru, Sayaka Ogi, Ryoko Sasaki, Hidetoshi Sunamoto, Hirohiko Fukiya, Hayato Nishiyama, Misato Kamura, Saki Niinou, Suico Mary Ann, Futoshi Nara, Tsuyoshi Shuto, Kazuhiro Onuma, Hirofumi Kai

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Ascotricins A and B, novel antagonists of sphingosine-1-phosphate receptor 1 from Ascotricha chartarum Berk. SANK 14186 by Yonesu, Kiyoaki, Ohnuki, Takashi, Ono, Yasunori, Takatsu, Toshio, Nara, Futoshi

“…Ascotricins A and B were isolated as novel sphingosine-1-phosphate receptor 1 (S1P 1 ) antagonists from a cultured broth of a fungus identified as Ascotricha…”
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Nerve Growth Factor-induced Glutamate Release Is via p75 Receptor, Ceramide, and Ca2+ from Ryanodine Receptor in Developing Cerebellar Neurons by Numakawa, Tadahiro, Nakayama, Hitoshi, Suzuki, Shingo, Kubo, Takekazu, Nara, Futoshi, Numakawa, Yumiko, Yokomaku, Daisaku, Araki, Toshiyuki, Ishimoto, Tetsuya, Ogura, Akihiko, Taguchi, Takahisa

“…Very little is known about the contribution of a low affinity neurotrophin receptor, p75, to neurotransmitter release. Here we show that nerve growth factor…”
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A Novel Sphingosine-1-Phosphate Receptor 1 Antagonist Prevents the Proliferation and Relaxation of Vascular Endothelial Cells by Sphingosine-1-Phosphate by Yonesu, Kiyoaki, Nakamura, Tsuyoshi, Mizuno, Yumiko, Suzuki, Chie, Nagayama, Takahiro, Satoh, Susumu, Nara, Futoshi

“…A sphingosine-1-phosphate receptor 1 (S1P1) antagonist is expected to be an anti-angiogenic compound; however, there are few reports that demonstrated that a…”
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Synthesis and SAR of 1,3-thiazolyl thiophene and pyridine derivatives as potent, orally active and S1P3-sparing S1P1 agonists by Asano, Masayoshi, Nakamura, Tsuyoshi, Sekiguchi, Yukiko, Mizuno, Yumiko, Yamaguchi, Takahiro, Tamaki, Kazuhiko, Shimozato, Takaichi, Doi-Komuro, Hiromi, Kagari, Takashi, Tomisato, Wataru, Inoue, Ryotaku, Yuita, Hiroshi, Oguchi-Oshima, Keiko, Kaneko, Reina, Nara, Futoshi, Kawase, Yumi, Masubuchi, Noriko, Nakayama, Shintaro, Koga, Tetsufumi, Namba, Eiko, Nasu, Hatsumi, Nishi, Takahide

“…A series of 1,3-thiazole derivatives were synthesized as potent, orally bioavailable S1P3-sparing S1P1 agonists. One of them, 24c, exhibited favorable efficacy…”
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Synthesis and evaluation of CS-2100, a potent, orally active and S1P3- sparing S1P1 agonist by Nakamura, Tsuyoshi, Asano, Masayoshi, Sekiguchi, Yukiko, Mizuno, Yumiko, Tamaki, Kazuhiko, Nara, Futoshi, Kawase, Yumi, Yabe, Yoshiyuki, Nakai, Daisuke, Kamiyama, Emi, Urasaki-Kaneno, Yoko, Shimozato, Takaichi, Doi-Komuro, Hiromi, Kagari, Takashi, Tomisato, Wataru, Inoue, Ryotaku, Nagasaki, Miyuki, Yuita, Hiroshi, Oguchi-Oshima, Keiko, Kaneko, Reina, Nishi, Takahide

“…Modulators of sphingosine phosphate receptor-1 (S1P1) have recently been focused as a suppressant of autoimmunity. We have discovered a 4-ethylthiophene-based…”
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Deorphanization of Dresden G Protein-Coupled Receptor for an Odorant Receptor by FUJITA, YOSHIFUMI, TAKAHASHI, TOMOKO, SUZUKI, AKIKO, KAWASHIMA, KAYO, NARA, FUTOSHI, KOISHI, RYUTA

“…Dresden G protein-coupled receptor (D-GPCR) is one of orphan G protein-coupled receptors (GPCR). Here we report the identification of the ligands and the…”
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