Search Results - "Futers, T Simon"

Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance by Rode, Baptiste, Shi, Jian, Endesh, Naima, Drinkhill, Mark J., Webster, Peter J., Lotteau, Sabine J., Bailey, Marc A., Yuldasheva, Nadira Y., Ludlow, Melanie J., Cubbon, Richard M., Li, Jing, Futers, T. Simon, Morley, Lara, Gaunt, Hannah J., Marszalek, Katarzyna, Viswambharan, Hema, Cuthbertson, Kevin, Baxter, Paul D., Foster, Richard, Sukumar, Piruthivi, Weightman, Andrew, Calaghan, Sarah C., Wheatcroft, Stephen B., Kearney, Mark T., Beech, David J.

“…Mammalian biology adapts to physical activity but the molecular mechanisms sensing the activity remain enigmatic. Recent studies have revealed how Piezo1…”
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Endothelial Piezo1 sustains muscle capillary density and contributes to physical activity by Bartoli, Fiona, Debant, Marjolaine, Chuntharpursat-Bon, Eulashini, Evans, Elizabeth L, Musialowski, Katie E, Parsonage, Gregory, Morley, Lara C, Futers, T Simon, Sukumar, Piruthivi, Bowen, T Scott, Kearney, Mark T, Lichtenstein, Laeticia, Roberts, Lee D, Beech, David J

“…Piezo1 forms mechanically activated nonselective cation channels that contribute to endothelial response to fluid flow. Here we reveal an important role in the…”
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Shear stress activates ADAM10 sheddase to regulate Notch1 via the Piezo1 force sensor in endothelial cells by Caolo, Vincenza, Debant, Marjolaine, Endesh, Naima, Futers, T Simon, Lichtenstein, Laeticia, Bartoli, Fiona, Parsonage, Gregory, Jones, Elizabeth Av, Beech, David J

“…Mechanical force is a determinant of Notch signalling but the mechanism of force detection and its coupling to Notch are unclear. We propose a role for Piezo1…”
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Sphingomyelinase Disables Inactivation in Endogenous PIEZO1 Channels by Shi, Jian, Hyman, Adam J., De Vecchis, Dario, Chong, Jiehan, Lichtenstein, Laeticia, Futers, T. Simon, Rouahi, Myriam, Salvayre, Anne Negre, Auge, Nathalie, Kalli, Antreas C., Beech, David J.

“…Endogenous PIEZO1 channels of native endothelium lack the hallmark inactivation often seen when these channels are overexpressed in cell lines. Because prior…”
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Sexual dimorphism in adipose tissue mitochondrial function and metabolic flexibility in obesity by MacCannell, Amanda D. V., Futers, T. Simon, Whitehead, Anna, Moran, Amy, Witte, Klaus K., Roberts, Lee D.

“…Objective The prevalence of obesity is growing globally. Adiposity increases the risk for metabolic syndrome, type 2 diabetes and cardiovascular disease…”
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Independent endothelial functions of PIEZO1 and TRPV4 in hepatic portal vein and predominance of PIEZO1 in mechanical and osmotic stress by Endesh, Naima, Chuntharpursat‐Bon, Eulashini, Revill, Charlotte, Yuldasheva, Nadira Y., Futers, T. Simon, Parsonage, Gregory, Humphreys, Neil, Adamson, Antony, Morley, Lara C., Cubbon, Richard M., Prasad, K. Raj, Foster, Richard, Lichtenstein, Laeticia, Beech, David J.

“…Background & Aims PIEZO1 and TRPV4 are mechanically and osmotically regulated calcium‐permeable channels. The aim of this study was to determine the relevance…”
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PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing by Chuntharpursat-Bon, Eulashini, Povstyan, Oleksandr V., Ludlow, Melanie J., Carrier, David J., Debant, Marjolaine, Shi, Jian, Gaunt, Hannah J., Bauer, Claudia C., Curd, Alistair, Simon Futers, T., Baxter, Paul D., Peckham, Michelle, Muench, Stephen P., Adamson, Antony, Humphreys, Neil, Tumova, Sarka, Bon, Robin S., Cubbon, Richard, Lichtenstein, Laeticia, Beech, David J.

“…Two prominent concepts for the sensing of shear stress by endothelium are the PIEZO1 channel as a mediator of mechanically activated calcium ion entry and the…”
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Global PIEZO1 Gain-of-Function Mutation Causes Cardiac Hypertrophy and Fibrosis in Mice by Bartoli, Fiona, Evans, Elizabeth L, Blythe, Nicola M, Stewart, Leander, Chuntharpursat-Bon, Eulashini, Debant, Marjolaine, Musialowski, Katie E, Lichtenstein, Laeticia, Parsonage, Gregory, Futers, T Simon, Turner, Neil A, Beech, David J

“…PIEZO1 is a subunit of mechanically-activated, nonselective cation channels. Gain-of-function PIEZO1 mutations are associated with dehydrated hereditary…”
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Effects of Novel Polymorphisms in the RAGE Gene on Transcriptional Regulation and Their Association With Diabetic Retinopathy by HUDSON, Barry I, STICKLAND, Max H, FUTERS, T. Simon, GRANT, Peter J

“…Effects of Novel Polymorphisms in the RAGE Gene on Transcriptional Regulation and Their Association With Diabetic Retinopathy Barry I. Hudson , Max H…”
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RBCs prevent rapid PIEZO1 inactivation and expose slow deactivation as a mechanism of dehydrated hereditary stomatocytosis by Evans, Elizabeth L., Povstyan, Oleksandr V., De Vecchis, Dario, Macrae, Fraser, Lichtenstein, Laeticia, Futers, T. Simon, Parsonage, Gregory, Humphreys, Neil E., Adamson, Antony, Kalli, Antreas C., Ludlow, Melanie J., Beech, David J.

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The Human Hydroxyacylglutathione Hydrolase (HAGH) Gene Encodes Both Cytosolic and Mitochondrial Forms of Glyoxalase II by Cordell, Paul A, Futers, T Simon, Grant, Peter J, Pease, Richard J

“…In yeast and higher plants, separate genes encode the cytosolic and mitochondrial forms of glyoxalase II. In contrast, although glyoxalase II activity has been…”
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Joint Linkage and Association of Six Single-Nucleotide Polymorphisms in the Factor XIII-A Subunit Gene Point to V34L As the Main Functional Locus by de Lange, Marlies, Andrew, Toby, Snieder, Harold, Ge, Dongliang, Futers, T Simon, Standeven, Kristina, Spector, Tim D, Grant, Peter J, Ariëns, Robert A.S

“…OBJECTIVE—Activated factor XIII (FXIII) crosslinks fibrin to enhance the mechanical strength of a blood clot and increase its resistance to fibrinolysis. The…”
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Novel Paracrine Action of Endothelium Enhances Glucose Uptake in Muscle and Fat by Viswambharan, Hema, Yuldasheva, Nadira Y., Imrie, Helen, Bridge, Katherine, Haywood, Natalie J., Skromna, Anna, Hemmings, Karen E., Clark, Emily R., Gatenby, V. Kate, Cordell, Paul, Simmons, Katie J., Makava, Natallia, Abudushalamu, Yilizila, Endesh, Naima, Brown, Jane, Walker, Andrew M.N., Futers, Simon T., Porter, Karen E., Cubbon, Richard M., Naseem, Khalid, Shah, Ajay M., Beech, David J., Wheatcroft, Stephen B., Kearney, Mark T., Sukumar, Piruthivi

“…[Figure: see text]…”
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Novel Role of the IGF-1 Receptor in Endothelial Function and Repair: Studies in Endothelium-Targeted IGF-1 Receptor Transgenic Mice by IMRIE, Helen, VISWAMBHARAN, Hema, TAQWEER RASHID, Sheik, FUTERS, T. Simon, SHOUHONG XUAN, GATENBY, V. Kate, GRANT, Peter J, CHANNON, Keith M, BEECH, David J, WHEATCROFT, Stephen B, KEARNEY, Mark T, SUKUMAR, Piruthivi, ABBAS, Afroze, CUBBON, Richard M, YULDASHEVA, Nadira, GAGE, Matthew, SMITH, Jessica, GALLOWAY, Stacey, SKROMNA, Anna

“…We recently demonstrated that reducing IGF-1 receptor (IGF-1R) numbers in the endothelium enhances nitric oxide (NO) bioavailability and endothelial cell…”
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Analysis of the tissue factor pathway inhibitor gene and antigen levels in relation to venous thrombosis by Amini‐Nekoo, Ali, Futers, T. Simon, Moia, Marco, Mannucci, Pier M., Grant, Peter J., Ariëns, Robert A. S.

“…Tissue factor pathway inhibitor (TFPI) inhibits tissue factor‐induced coagulation. The major part of TFPI is releasable by heparin. We recently found eight…”
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Endothelial force sensing signals to parenchymal cells to regulate bile and plasma lipids by Lichtenstein, Laeticia, Cheng, Chew W, Bajarwan, Muath, Evans, Elizabeth L, Gaunt, Hannah J, Bartoli, Fiona, Chuntharpursat-Bon, Eulashini, Patel, Shaili, Konstantinou, Charalampos, Futers, T Simon, Reay, Melanie, Parsonage, Gregory, Moore, J Bernadette, Bertrand-Michel, Justine, Sukumar, Piruthivi, Roberts, Lee D, Beech, David J

“…How cardiovascular activity interacts with lipid homeostasis is incompletely understood. We postulated a role for blood flow acting at endothelium in lipid…”
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Characterization of Allelic and Nucleotide Variation Between the RAGE Gene on Chromosome 6 and a Homologous Pseudogene Sequence to Its 5′ Regulatory Region on Chromosome 3 by Hudson, Barry I., Stickland, Max H., Grant, Peter J., Futers, T. Simon

“…Characterization of Allelic and Nucleotide Variation Between the RAGE Gene on Chromosome 6 and a Homologous Pseudogene Sequence to Its 5′ Regulatory Region on…”
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Human endothelial cell-derived nuclear proteins that recognise polymorphic DNA elements in the von Willebrand factor gene promoter include YY1 by Costa, M, Grant, P J, Rice, G I, Futers, T S, Medcalf, R L

“…Four common base-change polymorphisms have been found in the von Willebrand factor gene promoter: (-1793 C/G, -1234 T/C, -1185 G/A and -1051 A/G). All four…”
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CCAAT/enhancer binding protein alpha, beta and delta gene variants: associations with obesity related phenotypes in the Leeds Family Study by Bennett, Claire E, Nsengimana, Jérémie, Bostock, Jacqueline A, Cymbalista, Charlotte, Futers, T Simon, Knight, Bernice L, McCormack, Lynn J, Prasad, Usha K, Riches, Kirsten, Rolton, Daniel, Scarrott, Thomas, Barrett, Jennifer H, Carter, Angela M

“…To identify novel polymorphisms in the genes encoding the transcription factors CCAAT/enhancer binding protein alpha, beta and delta ( CEBPA, CEBPB, CEBPD) and…”
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Polymorphic Variants of Extracellular Superoxide Dismutase Gene in a Romanian Population with Atheroma by Samoila, Olguta C, Carter, Angela M, Futers, Simon T, Otiman, Gabriela, Anghel, Andrei, Tamas, Liviu, Seclaman, Edward

“…Extracellular superoxide dismutase (EC-SOD) is the main SOD isoform in the arterial wall contributing to cardiovascular defense against oxidative stress by…”
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