Usefulness of quantitative susceptibility mapping for the diagnosis of Parkinson disease

Quantitative susceptibility mapping allows overcoming several nonlocal restrictions of susceptibility-weighted and phase imaging and enables quantification of magnetic susceptibility. We compared the diagnostic accuracy of quantitative susceptibility mapping and R2* (1/T2*) mapping to discriminate b...

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Published in:	American journal of neuroradiology : AJNR Vol. 36; no. 6; pp. 1102 - 1108
Main Authors:	Murakami, Y, Kakeda, S, Watanabe, K, Ueda, I, Ogasawara, A, Moriya, J, Ide, S, Futatsuya, K, Sato, T, Okada, K, Uozumi, T, Tsuji, S, Liu, T, Wang, Y, Korogi, Y
Format:	Journal Article
Language:	English
Published:	United States American Society of Neuroradiology 01-06-2015
Subjects:	Aged Brain Brain - pathology Brain Mapping - methods Case-Control Studies Female Humans Image Enhancement - methods Image Interpretation, Computer-Assisted - methods Imaging, Three-Dimensional - methods Iron - metabolism Magnetic Resonance Imaging - methods Male Middle Aged Parkinson Disease - diagnosis Parkinson Disease - pathology Sensitivity and Specificity Substantia Nigra - pathology
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Summary:	Quantitative susceptibility mapping allows overcoming several nonlocal restrictions of susceptibility-weighted and phase imaging and enables quantification of magnetic susceptibility. We compared the diagnostic accuracy of quantitative susceptibility mapping and R2* (1/T2) mapping to discriminate between patients with Parkinson disease and controls. For 21 patients with Parkinson disease and 21 age- and sex-matched controls, 2 radiologists measured the quantitative susceptibility mapping values and R2 values in 6 brain structures (the thalamus, putamen, caudate nucleus, pallidum, substantia nigra, and red nucleus). The quantitative susceptibility mapping values and R2* values of the substantia nigra were significantly higher in patients with Parkinson disease (P < .01); measurements in other brain regions did not differ significantly between patients and controls. For the discrimination of patients with Parkinson disease from controls, receiver operating characteristic analysis suggested that the optimal cutoff values for the substantia nigra, based on the Youden Index, were >0.210 for quantitative susceptibility mapping and >28.8 for R2. The sensitivity, specificity, and accuracy of quantitative susceptibility mapping were 90% (19 of 21), 86% (18 of 21), and 88% (37 of 42), respectively; for R2 mapping, they were 81% (17 of 21), 52% (11 of 21), and 67% (28 of 42). Pair-wise comparisons showed that the areas under the receiver operating characteristic curves were significantly larger for quantitative susceptibility mapping than for R2* mapping (0.91 versus 0.69, P < .05). Quantitative susceptibility mapping showed higher diagnostic performance than R2* mapping for the discrimination between patients with Parkinson disease and controls.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0195-6108 1936-959X
DOI:	10.3174/ajnr.a4260