Search Results - "Futakawa, Satoshi"
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Structural basis for specific inhibition of Autotaxin by a DNA aptamer
Published in Nature structural & molecular biology (01-05-2016)“…SELEX selections and crystallographic analyses have allowed development of a DNA aptamer that inhibits autotaxin with high potency and specificity, and…”
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Anti-Angiogenic and Anti-Scarring Dual Action of an Anti-Fibroblast Growth Factor 2 Aptamer in Animal Models of Retinal Disease
Published in Molecular therapy. Nucleic acids (06-09-2019)“…Currently approved therapies for age-related macular degeneration (AMD) are inhibitors against vascular endothelial growth factor (VEGF), which is a major…”
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α2,6-Sialic Acid on Platelet Endothelial Cell Adhesion Molecule (PECAM) Regulates Its Homophilic Interactions and Downstream Antiapoptotic Signaling
Published in The Journal of biological chemistry (26-02-2010)“…Antiangiogenesis therapies are now part of the standard repertoire of cancer therapies, but the mechanisms for the proliferation and survival of endothelial…”
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4
High affinity sialoside ligands of myelin associated glycoprotein
Published in Bioorganic & medicinal chemistry letters (01-09-2011)“…Myelin associated glycoprotein (Siglec-4) is a myelin adhesion receptor, that is, well established for its role as an inhibitor of axonal outgrowth in nerve…”
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High Throughput ELISAs to Measure a Unique Glycan on Transferrin in Cerebrospinal Fluid : A Possible Extension toward Alzheimer's Disease Biomarker Development
Published in International journal of alzheimer's disease (2011)“…We have established high-throughput lectin-antibody ELISAs to measure different glycans on transferrin (Tf) in cerebrospinal fluid (CSF) using lectins and an…”
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'Glyco'-protein in cerebrospinal fluid as a diagnostic marker for dementia
Published in Nihon rinshō (01-10-2011)Get more information
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Glycan biomaker in CSF
Published in Rinsho shinkeigaku = Clinical neurology (2010)Get more information
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Sialoside Analogue Arrays for Rapid Identification of High Affinity Siglec Ligands
Published in Journal of the American Chemical Society (28-05-2008)“…The siglec family of sialic acid binding proteins participates in diverse cell surface biology that includes regulation of immune cell signaling and the…”
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A unique N-glycan on human transferrin in CSF: a possible biomarker for iNPH
Published in Neurobiology of aging (01-08-2012)“…Abstract Idiopathic normal pressure hydrocephalus (iNPH) is an elderly dementia caused by abnormal metabolism in the cerebrospinal fluid (CSF). The tap test is…”
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β-Galactoside α2,6-Sialyltransferase I Cleavage by BACE1 Enhances the Sialylation of Soluble Glycoproteins: A NOVEL REGULATORY MECHANISM FOR α2,6-SIALYLATION
Published in The Journal of biological chemistry (30-11-2007)“…BACE1 (β-site amyloid precursor protein-cleaving enzyme-1) is a membrane-bound aspartic protease that cleaves amyloid precursor protein to produce a neurotoxic…”
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beta -Galactoside alpha 2,6-Sialyltransferase I Cleavage by BACE1 Enhances the Sialylation of Soluble Glycoproteins: A NOVEL REGULATORY MECHANISM FOR alpha 2,6-SIALYLATION
Published in The Journal of biological chemistry (30-11-2007)“…BACE1 ( beta -site amyloid precursor protein-cleaving enzyme-1) is a membrane-bound aspartic protease that cleaves amyloid precursor protein to produce a…”
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12
Molecular insights into beta -galactoside alpha 2,6-sialyltransferase secretion in vivo
Published in Glycobiology (Oxford) (01-05-2009)“…beta -Galactoside alpha 2,6-sialyltransferase (ST6Gal I), which is highly expressed in the liver, is mainly cleaved by Alzheimer's beta -site amyloid precursor…”
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Molecular insights into β-galactoside α2,6-sialyltransferase secretion in vivo
Published in Glycobiology (Oxford) (01-05-2009)“…β-Galactoside α2,6-sialyltransferase (ST6Gal I), which is highly expressed in the liver, is mainly cleaved by Alzheimer's β-site amyloid precursor…”
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Development of sandwich enzyme-linked immunosorbent assay systems for plasma β-galactoside α2,6-sialyltransferase, a possible hepatic disease biomarker
Published in Analytica chimica acta (2009)“…Previous reports, including our work, have shown that plasma β-galactoside α2,6-sialyltransferase (ST6Gal I) activity is significantly increased in particular…”
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Development of sandwich enzyme-linked immunosorbent assay systems for plasma beta -galactoside alpha 2,6-sialyltransferase, a possible hepatic disease biomarker
Published in Analytica chimica acta (05-01-2009)“…Previous reports, including our work, have shown that plasma beta - galactoside alpha 2,6-sialyltransferase (ST6Gal I) activity is significantly increased in…”
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16
Development of sandwich enzyme-linked immunosorbent assay systems for plasma beta-galactoside alpha2,6-sialyltransferase, a possible hepatic disease biomarker
Published in Analytica chimica acta (05-01-2009)“…Previous reports, including our work, have shown that plasma beta-galactoside alpha2,6-sialyltransferase (ST6Gal I) activity is significantly increased in…”
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α2,6-Sialic Acid on Platelet Endothelial Cell Adhesion Molecule (PECAM) Regulates Its Homophilic Interactions and Downstream Antiapoptotic Signaling
Published in The Journal of biological chemistry (26-02-2010)“…Antiangiogenesis therapies are now part of the standard repertoire of cancer therapies, but the mechanisms for the proliferation and survival of endothelial…”
Get full text
Journal Article -
19
Beta-galactoside alpha2,6-sialyltransferase I cleavage by BACE1 enhances the sialylation of soluble glycoproteins. A novel regulatory mechanism for alpha2,6-sialylation
Published in The Journal of biological chemistry (30-11-2007)“…BACE1 (beta-site amyloid precursor protein-cleaving enzyme-1) is a membrane-bound aspartic protease that cleaves amyloid precursor protein to produce a…”
Get full text
Journal Article -
20
β-Galactoside α2,6-Sialyltransferase I Cleavage by BACE1 Enhances the Sialylation of Soluble Glycoproteins
Published in The Journal of biological chemistry (30-11-2007)“…BACE1 ( β -site a myloid precursor protein- c leaving e nzyme- 1 ) is a membrane-bound aspartic protease that cleaves amyloid precursor protein to produce a…”
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