Search Results - "Fuster, Mark M."

Integrating electromagnetic cancer stress with immunotherapy: a therapeutic paradigm by Fuster, Mark M

“…An array of published cell-based and small animal studies have demonstrated a variety of exposures of cancer cells or experimental carcinomas to…”
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Characterization of heparin and severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike glycoprotein binding interactions by Kim, So Young, Jin, Weihua, Sood, Amika, Montgomery, David W., Grant, Oliver C., Fuster, Mark M., Fu, Li, Dordick, Jonathan S., Woods, Robert J., Zhang, Fuming, Linhardt, Robert J.

“…Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has resulted in a pandemic and continues to spread around the globe at an unprecedented…”
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The sweet and sour of cancer: glycans as novel therapeutic targets by Esko, Jeffrey D, Fuster, Mark M

“…A growing body of evidence supports crucial roles for glycans at various pathophysiological steps of tumour progression. Glycans regulate tumour proliferation,…”
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The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions by Dyer, Douglas P., Salanga, Catherina L., Johns, Scott C., Valdambrini, Elena, Fuster, Mark M., Milner, Caroline M., Day, Anthony J., Handel, Tracy M.

“…TNF-stimulated gene-6 (TSG-6) is a multifunctional protein secreted in response to pro-inflammatory stimuli by a wide range of cells, including neutrophils,…”
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Pulsed Low-Frequency Magnetic Fields Induce Tumor Membrane Disruption and Altered Cell Viability by Ashdown, Christopher P., Johns, Scott C., Aminov, Edward, Unanian, Michael, Connacher, William, Friend, James, Fuster, Mark M.

“…Tumor cells express a unique cell surface glycocalyx with upregulation of sulfated glycosaminoglycans and charged glycoproteins. Little is known about how…”
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Targeting glycan sulfation in a CD11c+ myeloid population inhibits early KRAS-mutant lung neoplasia by Kim, So Young, Johns, Scott C., Gupta, Purva, Varki, Nissi, Fuster, Mark M

“…Early lung carcinoma development may be modulated by innate host cellular mechanisms that promote tumor growth and invasion. We recently identified how a…”
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Genetic alteration of heparan sulfate in CD11c + immune cells inhibits inflammation and facilitates pathogen clearance during influenza A virus infection by Kim, So Young, Gupta, Purva, Johns, Scott C., Zuniga, Elina I., Teijaro, John R., Fuster, Mark M.

“…Survival from influenza A virus (IAV) infection largely depends on an intricate balance between pathogen clearance and immunomodulation in the lung. We…”
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Functional Cellular Anti-Tumor Mechanisms are Augmented by Genetic Proteoglycan Targeting by Gupta, Purva, Johns, Scott C., Kim, So Young, El Ghazal, Roland, Zuniga, Elina I., Fuster, Mark M.

“…While recent research points to the importance of glycans in cancer immunity, knowledge on functional mechanisms is lacking. In lung carcinoma among other…”
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Surfen, a small molecule antagonist of heparan sulfate by Schuksz, Manuela, Fuster, Mark M, Brown, Jillian R, Crawford, Brett E, Ditto, David P, Lawrence, Roger, Glass, Charles A, Wang, Lianchun, Tor, Yitzhak, Esko, Jeffrey D

“…In a search for small molecule antagonists of heparan sulfate, we examined the activity of bis-2-methyl-4-amino-quinolyl-6-carbamide, also known as surfen…”
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Glycan Sulfation Modulates Dendritic Cell Biology and Tumor Growth by El Ghazal, Roland, Yin, Xin, Johns, Scott C, Swanson, Lee, Macal, Monica, Ghosh, Pradipta, Zuniga, Elina I, Fuster, Mark M

“…Abstract In cancer, proteoglycans have been found to play roles in facilitating the actions of growth factors, and effecting matrix invasion and remodeling…”
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Genetic Alteration of Endothelial Heparan Sulfate Selectively Inhibits Tumor Angiogenesis by Fuster, Mark M., Wang, Lianchun, Castagnola, Janice, Sikora, Lyudmila, Reddi, Krisanavane, Lee, Phillip H. A., Radek, Katherine A., Schuksz, Manuela, Bishop, Joseph R., Gallo, Richard L., Sriramarao, P., Esko, Jeffrey D.

“…To examine the role of endothelial heparan sulfate during angiogenesis, we generated mice bearing an endothelial-tarqceted deletion in the biosyn- thetic…”
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A general method for site specific fluorescent labeling of recombinant chemokines by Kawamura, Tetsuya, Stephens, Bryan, Qin, Ling, Yin, Xin, Dores, Michael R, Smith, Thomas H, Grimsey, Neil, Abagyan, Ruben, Trejo, Joann, Kufareva, Irina, Fuster, Mark M, Salanga, Catherina L, Handel, Tracy M

“…Chemokines control cell migration in many contexts including development, homeostasis, immune surveillance and inflammation. They are also involved in a wide…”
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IL‐33/ST2 receptor‐dependent signaling in the development of pulmonary hypertension in Sugen/hypoxia mice by Indralingam, Cynthia S., Gutierrez‐Gonzalez, Alma K., Johns, Scott C., Tsui, Tzuhan, Cannon, Daniel T., Fuster, Mark M., Bigby, Timothy D., Jennings, Patricia A., Breen, Ellen C.

“…Pulmonary arterial hypertension (PAH) is associated with significant morbidity and mortality. PAH is characterized by pulmonary artery remodeling, elevated…”
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Deficiency of Endothelial Heparan Sulfates Attenuates Allergic Airway Inflammation by Zuberi, Riaz I, Ge, Xiao Na, Jiang, Shuxia, Bahaie, Nooshin S, Kang, Bit Na, Hosseinkhani, Reza M, Frenzel, Elizabeth M, Fuster, Mark M, Esko, Jeffrey D, Rao, Savita P, Sriramarao, P

“…The effect of targeted inactivation of the gene encoding N-deacetylase/N-sulfotransferase-1 (Ndst1), a key enzyme involved in the biosynthesis of heparan…”
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A critical role for lymphatic endothelial heparan sulfate in lymph node metastasis by Yin, Xin, Truty, Jadwiga, Lawrence, Roger, Johns, Scott C, Srinivasan, R Sathish, Handel, Tracy M, Fuster, Mark M

“…Lymph node metastasis constitutes a key event in tumor progression. The molecular control of this process is poorly understood. Heparan sulfate is a linear…”
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Comparison of outcomes following stereotactic body radiotherapy for non-small cell lung cancer in patients with and without pathological confirmation by Haidar, Yarah M, Rahn, 3rd, Douglas A, Nath, Sameer, Song, William, Bazhenova, Lyudmila, Makani, Samir, Fuster, Mark M, Sandhu, Ajay P

“…Treatment of presumed early-stage lung cancer with definitive radiation therapy in the absence of a pathologically confirmed specimen frequently occurs…”
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A Disaccharide-Based Inhibitor of Glycosylation Attenuates Metastatic Tumor Cell Dissemination by Brown, Jillian R, Fuster, Mark M, Li, Ruixia, Varki, Nissi, Glass, Charles A, Esko, Jeffrey D

“…Purpose: The binding of hematogenously borne malignant cells that express the carbohydrate sialyl Lewis X (sLe X ) to selectin adhesion receptors on…”
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Glycocalyx transduces membrane leak in brain tumor cells exposed to sharp magnetic pulsing by Johns, Scott C, Gupta, Purva, Lee, Yi-Hung, Friend, James, Fuster, Mark M

“…Mechanisms by which electric (E) or magnetic (B) fields might be harnessed to affect tumor cell behavior remain poorly defined, presenting a barrier to…”
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Broad targeting of angiogenesis for cancer prevention and therapy by Wang, Zongwei, Dabrosin, Charlotta, Yin, Xin, Fuster, Mark M, Arreola, Alexandra, Rathmell, W. Kimryn, Generali, Daniele, Nagaraju, Ganji P, El-Rayes, Bassel, Ribatti, Domenico, Chen, Yi Charlie, Honoki, Kanya, Fujii, Hiromasa, Georgakilas, Alexandros G, Nowsheen, Somaira, Amedei, Amedeo, Niccolai, Elena, Amin, Amr, Ashraf, S. Salman, Helferich, Bill, Yang, Xujuan, Guha, Gunjan, Bhakta, Dipita, Ciriolo, Maria Rosa, Aquilano, Katia, Chen, Sophie, Halicka, Dorota, Mohammed, Sulma I, Azmi, Asfar S, Bilsland, Alan, Keith, W. Nicol, Jensen, Lasse D

“…Abstract Deregulation of angiogenesis – the growth of new blood vessels from an existing vasculature – is a main driving force in many severe human diseases…”
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Heparan Sulfate Regulates VEGF165- and VEGF121-mediated Vascular Hyperpermeability by Xu, Ding, Fuster, Mark M., Lawrence, Roger, Esko, Jeffrey D.

“…VEGF was first described as vascular permeability factor, a potent inducer of vascular leakage. Genetic evidence indicates that VEGF-stimulated endothelial…”
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