Search Results - "Fuster, J."

Obesity-Induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease by Fuster, José J, Ouchi, Noriyuki, Gokce, Noyan, Walsh, Kenneth

“…Obesity is causally linked with the development of cardiovascular disorders. Accumulating evidence indicates that cardiovascular disease is the collateral…”
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Somatic Mutations and Clonal Hematopoiesis: Unexpected Potential New Drivers of Age-Related Cardiovascular Disease by Fuster, José J, Walsh, Kenneth

“…Increasing evidence shows that conventional cardiovascular risk factors are incompletely predictive of cardiovascular disease, particularly in elderly…”
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Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice by Fuster, José J., MacLauchlan, Susan, Zuriaga, María A., Polackal, Maya N., Ostriker, Allison C., Chakraborty, Raja, Wu, Chia-Ling, Sano, Soichi, Muralidharan, Sujatha, Rius, Cristina, Vuong, Jacqueline, Jacob, Sophia, Muralidhar, Varsha, Robertson, Avril A. B., Cooper, Matthew A., Andrés, Vicente, Hirschi, Karen K., Martin, Kathleen A., Walsh, Kenneth

“…Human aging is associated with an increased frequency of somatic mutations in hematopoietic cells. Several of these recurrent mutations, including those in the…”
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Clonal hematopoiesis and cardiovascular disease in cancer patients and survivors by Fuster, José J.

“…Cancer genomes have long been known to carry a high number of somatic mutations distributed across many genes. However, recent sequencing studies have unveiled…”
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Telomere Biology and Cardiovascular Disease by Fuster, José J, Andrés, Vicente

“…Accumulation of cellular damage with advancing age leads to atherothrombosis and associated cardiovascular disease. Ageing is also characterized by shortening…”
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Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome by Sano, Soichi, Oshima, Kosei, Wang, Ying, MacLauchlan, Susan, Katanasaka, Yasufumi, Sano, Miho, Zuriaga, María A., Yoshiyama, Minoru, Goukassian, David, Cooper, Matthew A., Fuster, José J., Walsh, Kenneth

“…Recent studies have shown that hematopoietic stem cells can undergo clonal expansion secondary to somatic mutations in leukemia-related genes, thus leading to…”
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The Good, the Bad, and the Ugly of interleukin-6 signaling by Fuster, José J, Walsh, Kenneth

“…Interleukin‐6 (IL‐6) is a pleiotropic cytokine with complex roles in inflammation and metabolic disease. While typically regarded as a pro‐inflammatory…”
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Clonal Hematopoiesis and Incident Heart Failure Risk: The Clone Wars Reach the Myocardium by Fuster, José J.

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TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity by Fuster, José J., Zuriaga, María A., Zorita, Virginia, MacLauchlan, Susan, Polackal, Maya N., Viana-Huete, Vanesa, Ferrer-Pérez, Alba, Matesanz, Nuria, Herrero-Cervera, Andrea, Sano, Soichi, Cooper, Matthew A., González-Navarro, Herminia, Walsh, Kenneth

“…Human aging is frequently accompanied by the acquisition of somatic mutations in the hematopoietic system that induce clonal hematopoiesis, leading to the…”
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Jet reconstruction at high-energy electron–positron colliders by Boronat, M., Fuster, J., Garcia, I., Roloff, Ph, Simoniello, R., Vos, M.

“…In this paper we study the performance in e + e - collisions of classical e + e - jet reconstruction algorithms, longitudinally invariant algorithms and the…”
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Secreted Frizzled-related Protein 5 Diminishes Cardiac Inflammation and Protects the Heart from Ischemia/Reperfusion Injury by Nakamura, Kazuto, Sano, Soichi, Fuster, José J., Kikuchi, Ryosuke, Shimizu, Ippei, Ohshima, Kousei, Katanasaka, Yasufumi, Ouchi, Noriyuki, Walsh, Kenneth

“…Wnt signaling has diverse actions in cardiovascular development and disease processes. Secreted frizzled-related protein 5 (Sfrp5) has been shown to function…”
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Noncanonical Wnt signaling promotes obesity-induced adipose tissue inflammation and metabolic dysfunction independent of adipose tissue expansion by Fuster, José J, Zuriaga, María A, Ngo, Doan Thi-Minh, Farb, Melissa G, Aprahamian, Tamar, Yamaguchi, Terry P, Gokce, Noyan, Walsh, Kenneth

“…Adipose tissue dysfunction plays a pivotal role in the development of insulin resistance in obese individuals. Cell culture studies and gain-of-function mouse…”
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Clonal haematopoiesis and atherosclerosis: a chicken or egg question? by Sánchez-Cabo, Fátima, Fuster, José J.

“…Sequencing studies demonstrate a strong clinical association between clonal haematopoiesis driven by acquired mutations and atherosclerotic disease. Previous…”
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Clonal Hematopoiesis in Patients With Atherosclerotic Cardiovascular Disease: One Step Closer to the Clinical Scenario by Fuster, José J., Izzi, Benedetta

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Functional recovery in patients with schizophrenia: recommendations from a panel of experts by Lahera, Guillermo, Gálvez, José L, Sánchez, Pedro, Martínez-Roig, Miguel, Pérez-Fuster, J V, García-Portilla, Paz, Herrera, Berta, Roca, Miquel

“…The management of schizophrenia is evolving towards a more comprehensive model based on functional recovery. The concept of functional recovery goes beyond…”
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Integrated Stress Response Inhibition in Atherosclerosis: Preventing the Stressed-Out Plaque by Fuster, José J.

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Clonal Hematopoiesis and Risk of Progression of Heart Failure With Reduced Left Ventricular Ejection Fraction by Pascual-Figal, Domingo A, Bayes-Genis, Antoni, Díez-Díez, Miriam, Hernández-Vicente, Álvaro, Vázquez-Andrés, David, de la Barrera, Jorge, Vazquez, Enrique, Quintas, Ana, Zuriaga, María A, Asensio-López, Mari C, Dopazo, Ana, Sánchez-Cabo, Fátima, Fuster, José J

“…Clonal hematopoiesis driven by somatic mutations in hematopoietic cells, frequently called clonal hematopoiesis of indeterminate potential (CHIP), has been…”
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Emerging Role of Acquired Mutations and Clonal Hematopoiesis in Atherosclerosis　― Beyond Conventional Cardiovascular Risk Factors by Zuriaga, María A., Fuster, José J.

“…Accumulating evidence suggests that conventional cardiovascular risk factors are incompletely predictive of cardiovascular disease, as a substantial risk…”
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Clonal hematopoiesis driven by somatic mutations: A new player in atherosclerotic cardiovascular disease by Amorós-Pérez, Marta, Fuster, José J.

“…The accumulation of acquired mutations is an inevitable consequence of the aging process, but its pathophysiological relevance has remained largely unexplored…”
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TLR4 in Atherogenesis: Paying the Toll for Antimicrobial Defense by Fuster, José J.

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