Search Results - "Fuso Nerini, Ilaria"

Role of Macrophage Targeting in the Antitumor Activity of Trabectedin by Germano, Giovanni, Frapolli, Roberta, Belgiovine, Cristina, Anselmo, Achille, Pesce, Samantha, Liguori, Manuela, Erba, Eugenio, Uboldi, Sarah, Zucchetti, Massimo, Pasqualini, Fabio, Nebuloni, Manuela, van Rooijen, Nico, Mortarini, Roberta, Beltrame, Luca, Marchini, Sergio, Fuso Nerini, Ilaria, Sanfilippo, Roberta, Casali, Paolo G., Pilotti, Silvana, Galmarini, Carlos M., Anichini, Andrea, Mantovani, Alberto, D’Incalci, Maurizio, Allavena, Paola

“…There is widespread interest in macrophages as a therapeutic target in cancer. Here, we demonstrate that trabectedin, a recently approved chemotherapeutic…”
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Heterogeneity of paclitaxel distribution in different tumor models assessed by MALDI mass spectrometry imaging by Giordano, Silvia, Zucchetti, Massimo, Decio, Alessandra, Cesca, Marta, Fuso Nerini, Ilaria, Maiezza, Marika, Ferrari, Mariella, Licandro, Simonetta Andrea, Frapolli, Roberta, Giavazzi, Raffaella, Maurizio, D’Incalci, Davoli, Enrico, Morosi, Lavinia

“…The penetration of anticancer drugs in solid tumors is important to ensure the therapeutic effect, so methods are needed to understand drug distribution in…”
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Association between miR-200c and the survival of patients with stage I epithelial ovarian cancer: a retrospective study of two independent tumour tissue collections by Marchini, Sergio, PhD, Cavalieri, Duccio, Prof, Fruscio, Robert, MD, Calura, Enrica, BSc, Garavaglia, Daniela, BSc, Nerini, Ilaria Fuso, BSc, Mangioni, Costantino, Prof, Cattoretti, Giorgio, Prof, Clivio, Luca, Eng, Beltrame, Luca, PhD, Katsaros, Dionyssios, MD, Scarampi, Luca, MD, Menato, Guido, MD, Perego, Patrizia, MD, Chiorino, Giovanna, PhD, Buda, Alessandro, MD, Romualdi, Chiara, PhD, D'Incalci, Maurizio, Dr

“…Summary Background International Federation of Gynecology and Obstetrics stage I epithelial ovarian cancer (EOC) has a significantly better prognosis than…”
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PEGylated recombinant human hyaluronidase (PEGPH20) pre-treatment improves intra-tumour distribution and efficacy of paclitaxel in preclinical models by Morosi, Lavinia, Meroni, Marina, Ubezio, Paolo, Fuso Nerini, Ilaria, Minoli, Lucia, Porcu, Luca, Panini, Nicolò, Colombo, Marika, Blouw, Barbara, Kang, David W, Davoli, Enrico, Zucchetti, Massimo, D'Incalci, Maurizio, Frapolli, Roberta

“…Scarce drug penetration in solid tumours is one of the possible causes of the limited efficacy of chemotherapy and is related to the altered tumour…”
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Combination therapy in cancer：effects of angiogenesis inhibitors on drug pharmacokinetics and pharmacodynamics by Fuso Nerini, Ilaria, Cesca, Marta, Bizzaro, Francesca, Giavazzi, Raffaella

“…Validated preclinical studies have provided evidence that anti-vascular endothelial growth factor（VEGF） compounds enhance the activity of subsequent antitumor…”
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miRNA Landscape in Stage I Epithelial Ovarian Cancer Defines the Histotype Specificities by CALURA, Enrica, FRUSCIO, Robert, DI MARINO, Mariacristina, NERINI, Ilaria Fuso, ZANOTTI, Laura, CAVALIERI, Duccio, CATTORETTI, Giorgio, PEREGO, Patrizia, MILANI, Rodolfo, KATSAROS, Dionyssios, TOGNON, Germana, SARTORI, Enrico, PARACCHINI, Lara, PECORELLI, Sergio, MANGIONI, Costantino, D'INCALCI, Maurizio, ROMUALDI, Chiara, MARCHINI, Sergio, BIGNOTTI, Eliana, RAVAGGI, Antonella, MARTINI, Paolo, SALES, Gabriele, BELTRAME, Luca, CLIVIO, Luca, CEPPI, Lorenzo

“…Epithelial ovarian cancer (EOC) is one of the most lethal gynecologic diseases, with survival rate virtually unchanged for the past 30 years. EOC comprises…”
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A systems biology approach to characterize the regulatory networks leading to trabectedin resistance in an in vitro model of myxoid liposarcoma by Uboldi, Sarah, Calura, Enrica, Beltrame, Luca, Fuso Nerini, Ilaria, Marchini, Sergio, Cavalieri, Duccio, Erba, Eugenio, Chiorino, Giovanna, Ostano, Paola, D'Angelo, Daniela, D'Incalci, Maurizio, Romualdi, Chiara

“…Trabectedin, a new antitumor compound originally derived from a marine tunicate, is clinically effective in soft tissue sarcoma. The drug has shown a high…”
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Is DNA repair a potential target for effective therapies against malignant mesothelioma? by Fuso Nerini, Ilaria, Roca, Elisa, Mannarino, Laura, Grosso, Federica, Frapolli, Roberta, D'Incalci, Maurizio

“…•Defects in DNA repair affect pathogenesis of malignant pleural mesothelioma.•Mutations in homologous recombination are frequent in mesothelioma.•Alterations…”
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Quantitative measurement of pioglitazone in neoplastic and normal tissues by AP-MALDI mass spectrometry imaging by Morosi, Lavinia, Matteo, Cristina, Meroni, Marina, Ceruti, Tommaso, Fuso Nerini, Ilaria, Bello, Ezia, Frapolli, Roberta, D'Incalci, Maurizio, Zucchetti, Massimo, Davoli, Enrico

“…Pioglitazone is a Peroxisome Proliferator-Activated Receptor (PPAR) agonist of the thiazolidinedione class of compounds with promising anticancer activity. An…”
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Resistance to platinum-based chemotherapy is associated with epithelial to mesenchymal transition in epithelial ovarian cancer by Marchini, Sergio, Fruscio, Robert, Clivio, Luca, Beltrame, Luca, Porcu, Luca, Nerini, Ilaria Fuso, Cavalieri, Duccio, Chiorino, Giovanna, Cattoretti, Giorgio, Mangioni, Costantino, Milani, Rodolfo, Torri, Valter, Romualdi, Chiara, Zambelli, Alberto, Romano, Michela, Signorelli, Mauro, Giandomenico, Silvana di, D’Incalci, Maurizio

“…Abstract Background The present study is aimed to identify genetic pathways correlated with chemoresistance in epithelial ovarian cancer (EOC). Methods We…”
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Bevacizumab-Induced Inhibition of Angiogenesis Promotes a More Homogeneous Intratumoral Distribution of Paclitaxel, Improving the Antitumor Response by Cesca, Marta, Morosi, Lavinia, Berndt, Alexander, Fuso Nerini, Ilaria, Frapolli, Roberta, Richter, Petra, Decio, Alessandra, Dirsch, Olaf, Micotti, Edoardo, Giordano, Silvia, D'Incalci, Maurizio, Davoli, Enrico, Zucchetti, Massimo, Giavazzi, Raffaella

“…The antitumor activity of angiogenesis inhibitors is reinforced in combination with chemotherapy. It is debated whether this potentiation is related to a…”
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VEGF pathway inhibition potentiates PARP inhibitor efficacy in ovarian cancer independent of BRCA status by Bizzaro, Francesca, Fuso Nerini, Ilaria, Taylor, Molly A, Anastasia, Alessia, Russo, Massimo, Damia, Giovanna, Guffanti, Federica, Guana, Francesca, Ostano, Paola, Minoli, Lucia, Hattersley, Maureen M, Arnold, Stephanie, Ramos-Montoya, Antonio, Williamson, Stuart C, Galbiati, Alessandro, Urosevic, Jelena, Leo, Elisabetta, Cavallaro, Ugo, Ghilardi, Carmen, Barry, Simon T, Bani, Maria Rosa, Giavazzi, Raffaella

“…Poly ADP-ribose polymerase inhibitors (PARPi) have transformed ovarian cancer (OC) treatment, primarily for tumours deficient in homologous recombination…”
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Genomic instability analysis in DNA from Papanicolaou test provides proof-of-principle early diagnosis of high-grade serous ovarian cancer by Paracchini, Lara, Mannarino, Laura, Romualdi, Chiara, Zadro, Riccardo, Beltrame, Luca, Fuso Nerini, Ilaria, Zola, Paolo, Laudani, Maria E, Pagano, Eva, Giordano, Livia, Fruscio, Robert, Landoni, Fabio, Franceschi, Silvia, Dalessandro, Maria L, Canzonieri, Vincenzo, Bocciolone, Luca, Lorusso, Domenica, Bosetti, Cristina, Raspagliesi, Francesco, Garassino, Isabella M G, D'Incalci, Maurizio, Marchini, Sergio

“…Late diagnosis and the lack of screening methods for early detection define high-grade serous ovarian cancer (HGSOC) as the gynecological malignancy with the…”
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Abstract 3377: Bevacizumab-improved distribution of paclitaxel in ovarian cancer xenografts potentiates antitumor efficacy by Cesca, Marta, Morosi, Lavinia, Berndt, Alexander, Fuso Nerini, Ilaria, Decio, Alessandra, Zucchetti, Massimo, Giavazzi, Raffaella

“…Angiogenesis inhibitors have shown antitumor efficacy when combined with chemotherapy. It has been proposed that this potentiation is related to better drug…”
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Pharmacodynamic effects in the cerebrospinal fluid of rats after intravenous administration of different asparaginase formulations by Ballerini, Andrea, Moro, Federico, Nerini, Ilaria Fuso, Marzo, Claudio Marcello, Di Clemente, Angelo, Ferrari, Mariella, D’Incalci, Maurizio, Biondi, Andrea, Colombini, Antonella, Conter, Valentino, Porcu, Luca, Cervo, Luigi, Rizzari, Carmelo, Zucchetti, Massimo

“…Purpose Asparaginase (ASNase) is used to treat various hematological malignancies for its capacity to deplete asparagine (ASN) in serum and cerebrospinal fluid…”
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Trabectedin and indole-3-carbinol combination in heavily pretreated metastatic breast cancer: Results of a pilot clinical study by Zambelli, Alberto, Tancredi, Richard, Negri, Sara, Cattrini, Carlo, Ponchio, Luisa, Frascaroli, Mara, Da Prada, Gian Antonio, Fregoni, Vittorio, Pavesi, Lorenzo, Riccardi, Alberto, Zucchetti, Massimo, Fuso Nerini, Ilaria, D'Incalci, Maurizio

“…Abstract only…”
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