Search Results - "Fusenig, Norbert E"

The need for a worldwide consensus for cell line authentication: Experience implementing a mandatory requirement at the International Journal of Cancer by Fusenig, Norbert E, Capes-Davis, Amanda, Bianchini, Franca, Sundell, Sherryl, Lichter, Peter

“…Cell lines are used in life science research worldwide as biological surrogates. All cell lines are subject to major limitations when used as research tools,…”
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IL‐6 promotes malignant growth of skin SCCs by regulating a network of autocrine and paracrine cytokines by Lederle, Wiltrud, Depner, Sofia, Schnur, Sabine, Obermueller, Eva, Catone, Nicola, Just, Alexandra, Fusenig, Norbert E., Mueller, Margareta M.

“…Cytokines play a crucial role in tumor initiation and progression. Here, we demonstrate that interleukin (IL)‐6 is a key factor by driving tumor progression…”
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Granulocyte colony-stimulating factor and granulocyte- macrophage colony-stimulating factor promote malignant growth of cells from head and neck squamous cell carcinomas in vivo by GUTSCHALK, Claudia M, HEROLD-MENDE, Christel C, FUSENIG, Norbert E, MUELLER, Margareta M

“…Granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) are used to ameliorate cancer therapy-induced…”
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Effects of fibroblasts and microenvironment on epidermal regeneration and tissue function in long-term skin equivalents by Boehnke, Karsten, Mirancea, Nicolae, Pavesio, Alessandra, Fusenig, Norbert E., Boukamp, Petra, Stark, Hans-Jürgen

“…In vitro generated skin models find growing interest as promising tools in basic research and clinical application in regenerative medicine. Here, we present…”
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Epidermal homeostasis in long-term scaffold-enforced skin equivalents by Stark, Hans-Jürgen, Boehnke, Karsten, Mirancea, Nicolae, Willhauck, Michael J, Pavesio, Alessandra, Fusenig, Norbert E, Boukamp, Petra

“…Epidermal homeostasis is understood as the maintenance of epidermal tissue structure and function by a fine tuned regulatory mechanism balancing proliferation…”
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Angiogenesis inhibition by vascular endothelial growth factor receptor-2 blockade reduces stromal matrix metalloproteinase expression, normalizes stromal tissue, and reverts epithelial tumor phenotype in surface heterotransplants by VOSSELER, Silvia, MIRANCEA, Nicolae, BOHLEN, Peter, MUELLER, Margareta M, FUSENIG, Norbert E

“…Inhibition of vascular endothelial growth factor (VEGF) signaling, a key regulator of tumor angiogenesis, through blockade of VEGF receptor (VEGFR)-2 by the…”
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c-Jun and JunB Antagonistically Control Cytokine-Regulated Mesenchymal–Epidermal Interaction in Skin by Szabowski, Axel, Maas-Szabowski, Nicole, Andrecht, Sven, Kolbus, Andrea, Schorpp-Kistner, Marina, Fusenig, Norbert E, Angel, Peter

“…Interactions between mesenchymal and epithelial cells are responsible for organogenesis and tissue homeostasis. This mutual cross-talk involves cell surface…”
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Volumetric computed tomography (VCT): a new technology for noninvasive, high-resolution monitoring of tumor angiogenesis by Kiessling, Fabian, Greschus, Susanne, Lichy, Matthias P, Bock, Michael, Fink, Christian, Vosseler, Silvia, Moll, Jens, Mueller, Margareta M, Fusenig, Norbert E, Traupe, Horst, Semmler, Wolfhard

“…Volumetric computed tomography (VCT) is a technology in which area detectors are used for imaging large volumes of a subject with isotropic imaging resolution…”
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Cooperative autocrine and paracrine functions of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor in the progression of skin carcinoma cells by OBERMUELLER, Eva, VOSSELER, Silvia, FUSENIG, Norbert E, MUELLER, Margareta M

“…Tumor growth and progression are critically controlled by alterations in the microenvironment often caused by an aberrant expression of growth factors and…”
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Tumor-stroma interactions directing phenotype and progression of epithelial skin tumor cells by Mueller, Margareta M., Fusenig, Norbert E.

“…Tumor-stroma interactions play a significant role in tumor development and progression. Alterations in the stromal microenvironment, including enhanced…”
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E-cadherin suppression accelerates squamous cell carcinoma progression in three-dimensional, human tissue constructs by MARGULIS, Alexander, ZHANG, Weitian, ALT-HOLLAND, Addy, CRAWFORD, Howard C, FUSENIG, Norbert E, GARLICK, Jonathan A

“…We studied the link between loss of E-cadherin-mediated adhesion and acquisition of malignant properties in three-dimensional, human tissue constructs that…”
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Targeting Perlecan in Human Keratinocytes Reveals Novel Roles for Perlecan in Epidermal Formation by Sher, Ifat, Zisman-Rozen, Simona, Eliahu, Liat, Whitelock, John M., Maas-Szabowski, Nicole, Yamada, Yoshihiko, Breitkreutz, Dirk, Fusenig, Norbert E., Arikawa-Hirasawa, Eri, Iozzo, Renato V., Bergman, Reuven, Ron, Dina

“…Heparin-binding growth factors are crucial for the formation of human epidermis, but little is known about the role of heparan sulfate proteoglycans in this…”
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Tumorigenic Conversion of Immortal Human Keratinocytes through Stromal Cell Activation by Skobe, Mihaela, Fusenig, Norbert E.

“…The stromal microenvironment plays a crucial role in tumor development and progression. One of the most potent activators of stromal cells is the…”
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Keratinocyte Growth Regulation in Defined Organotypic Cultures Through IL-1-Induced Keratinocyte Growth Factor Expression in Resting Fibroblasts by Maas-Szabowski, Nicole, Stark, Hans-Jürgen, Fusenig, Norbert E.

“…Balanced keratinocyte proliferation and differentiation resulting in regular tissue organization strictly depend on dermal support. Organotypic cultures…”
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E-cadherin loss promotes the initiation of squamous cell carcinoma invasion through modulation of integrin-mediated adhesion by Zhang, Weitian, Alt-Holland, Addy, Margulis, Alexander, Shamis, Yulia, Fusenig, Norbert E, Rodeck, Ulrich, Garlick, Jonathan A

“…Much remains to be learned about how cell-cell and cell-matrix interactions are coordinated to influence the earliest development of neoplasia. We used novel…”
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Cell line authentication: a necessity for reproducible biomedical research by Souren, Nicole Y, Fusenig, Norbert E, Heck, Stefanie, Dirks, Wilhelm G, Capes‐Davis, Amanda, Bianchini, Franca, Plass, Christoph

“…Immortalized or continuous cell lines are invaluable tools in basic and preclinical research. However, the widespread use of misidentified cell lines is a…”
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Friends or foes - bipolar effects of the tumour stroma in cancer by Fusenig, Norbert E, Mueller, Margareta M

“…The restricted view of tumour progression as a multistep process defined by the accumulation of mutations in cancer cells has largely ignored the substantial…”
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Vascular anomalies in lipoid proteinosis ( hyalinosis cutis et mucosae): Basement membrane components and ultrastructure by Mirancea, Nicolae, Hausser, Ingrid, Beck, Regina, Metze, Dieter, Fusenig, Norbert E., Breitkreutz, Dirk

“…In lipoid proteinosis (LP) vascular anomalies represent severe functional defects caused by excessive deposition of basement membrane (BM)-like matrix,…”
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Potential Applications of Flat-Panel Volumetric CT in Morphologic, Functional Small Animal Imaging by Greschus, Susanne, Kiessling, Fabian, Lichy, Matthias P., Moll, Jens, Mueller, Margareta M., Savai, Rajkumar, Rose, Frank, Ruppert, Clemens, Günther, Andreas, Luecke, Marcus, Fusenig, Norbert E., Semmler, Wolfhard, Traupe, Horst

“…Noninvasive radiologic imaging has recently gained considerable interest in basic, preclinical research for monitoring disease progression, therapeutic…”
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Tumor Suppression in Human Skin Carcinoma Cells by Chromosome 15 Transfer or Thrombospondin-1 Overexpression Through Halted Tumor Vascularization by Bleuel, Kerstin, Popp, Susanne, Fusenig, Norbert E., Stanbridge, Eric J., Boukamp, Petra

“…The development of skin carcinomas presently is believed to be correlated with mutations in the p53 tumor suppressor and ras gene as well as with the loss of…”
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