Search Results - "Furuichi, Masato"

The association of COVID-19 employment shocks with suicide and safety net use: An early-stage investigation by Ando, Michihito, Furuichi, Masato

“…This paper examines whether the COVID-19-induced employment shocks are associated with increases in suicides and safety net use in the second and third…”
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Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs by Oka, Sugako, Ohno, Mizuki, Tsuchimoto, Daisuke, Sakumi, Kunihiko, Furuichi, Masato, Nakabeppu, Yusaku

“…Oxidative base lesions, such as 8‐oxoguanine (8‐oxoG), accumulate in nuclear and mitochondrial DNAs under oxidative stress, resulting in cell death. However,…”
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An Oxidized Purine Nucleoside Triphosphatase, MTH1, Suppresses Cell Death Caused by Oxidative Stress by Yoshimura, Daisuke, Sakumi, Kunihiko, Ohno, Mizuki, Sakai, Yasunari, Furuichi, Masato, Iwai, Shigenori, Nakabeppu, Yusaku

“…MTH1 hydrolyzes oxidized purine nucleoside triphosphates such as 8-oxo-2′-deoxyguanosine 5′-triphosphate (8-oxo-dGTP) and 2-hydroxy-2′-deoxyadenosine…”
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Oxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell death by Ichikawa, Junji, Tsuchimoto, Daisuke, Oka, Sugako, Ohno, Mizuki, Furuichi, Masato, Sakumi, Kunihiko, Nakabeppu, Yusaku

“…Human MutT homolog (hMTH1) hydrolyzes oxidized purine nucleoside triphosphates to monophosphates, thereby avoiding incorporation of such oxidized purines into…”
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MTH1, an Oxidized Purine Nucleoside Triphosphatase, Suppresses the Accumulation of Oxidative Damage of Nucleic Acids in the Hippocampal Microglia during Kainate-Induced Excitotoxicity by Kajitani, Kosuke, Yamaguchi, Hiroo, Dan, Yukihiko, Furuichi, Masato, Kang, Dongchon, Nakabeppu, Yusaku

“…Enhanced oxidative stress has been implicated in the excitotoxicity of the CNS, and 8-oxo-7,8-dihydro-guanine (8-oxoG), a major type of oxidative damage in…”
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The Oxidized Deoxynucleoside Triphosphate Pool Is a Significant Contributor to Genetic Instability in Mismatch Repair-Deficient Cells by Russo, Maria Teresa, Blasi, Monica Francesca, Chiera, Federica, Fortini, Paola, Degan, Paolo, Macpherson, Peter, Furuichi, Masato, Nakabeppu, Yusaku, Karran, Peter, Aquilina, Gabriele, Bignami, Margherita

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Biological Significance of the Defense Mechanisms against Oxidative Damage in Nucleic Acids Caused by Reactive Oxygen Species: From Mitochondria to Nuclei by NAKABEPPU, YUSAKU, TSUCHIMOTO, DAISUKE, ICHINOE, AKIMASA, OHNO, MIZUKI, IDE, YASUHITO, HIRANO, SEIKI, YOSHIMURA, DAISUKE, TOMINAGA, YOHEI, FURUICHI, MASATO, SAKUMI, KUNIHIKO

“…: In mammalian cells, more than one genome in a single cell has to be maintained throughout the entire life of the cell, namely, one in the nucleus and the…”
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Structure of Human MTH1, a Nudix Family Hydrolase That Selectively Degrades Oxidized Purine Nucleoside Triphosphates by Mishima, Masaki, Sakai, Yasunari, Itoh, Noriyuki, Kamiya, Hiroyuki, Furuichi, Masato, Takahashi, Masayuki, Yamagata, Yuriko, Iwai, Shigenori, Nakabeppu, Yusaku, Shirakawa, Masahiro

“…Oxygen radicals generated through normal cellular respiration processes can cause mutations in genomic and mitochondrial DNA. Human MTH1 hydrolyzes oxidized…”
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Accumulation of 8-oxoguanine in the cellular DNA and the alteration of the OGG1 expression during ischemia-reperfusion injury in the rat kidney by Tsuruya, Kazuhiko, Furuichi, Masato, Tominaga, Yohei, Shinozaki, Michiya, Tokumoto, Masanori, Yoshimitsu, Takahiro, Fukuda, Kyoichi, Kanai, Hidetoshi, Hirakata, Hideki, Iida, Mitsuo, Nakabeppu, Yusaku

“…During ischemia-reperfusion (I/R) injury in the rat kidney, apoptosis was observed in the distal tubules of the cortico-medullary region and outer medulla (OM)…”
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A Molecular Basis for the Selective Recognition of 2-Hydroxy-dATP and 8-Oxo-dGTP by Human MTH1 by Sakai, Yasunari, Furuichi, Masato, Takahashi, Masayuki, Mishima, Masaki, Iwai, Shigenori, Shirakawa, Masahiro, Nakabeppu, Yusaku

“…MTH1 hydrolyzes oxidized purine nucleoside triphosphates such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP to monophosphates, and thus avoids…”
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Intracellular Localization of 8-Oxo-dGTPase in Human Cells, with Special Reference to the Role of the Enzyme in Mitochondria by Kang, Dongchon, Nishida, Jun-ichi, Iyama, Akihiro, Nakabeppu, Yusaku, Furuichi, Masato, Fujiwara, Toshiyuki, Sekiguchi, Mutsuo, Takeshige, Koichiro

“…We examined the intracellular distribution of 8-oxo-dGTPase (8-oxo-7,8-dihydrodeoxyguanosine triphosphatase) encoded by the MTH1 gene, a human mutator…”
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2D-01 8-Oxoguanine increases the frequency of meiotic homologus recombination via DNA strand breaks in mouse tissues by OHNO Mizuki, SAKUMI Kunihiko, FURUICHI Masato, NAKANISHI Megumi, TSUZUKI Teruhisa, NAKABEPPU Yusaku

“…To evaluate the contribution of 8-oxoguanine (8-oxoG) in meiotic homologous recombination, we compared the frequency of meiotic recombination in spermatocytes…”
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General sessions1D-05 The influence of oxidative damaged base on germ-line mutation by OHNO Mizuki, SAKUMI Kunihiko, FURUICHI Masato, TSUZUKI Teruhisa, NAKABEPPU Yusaku

“…We have suggested that 8-oxoguanine (8-oxoG) is one of the main causes of base substitution and chromosome recombination in the mammalian genome. To elucidate…”
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8-oxoguanine causes spontaneous de novo germline mutations in mice by Ohno, Mizuki, Sakumi, Kunihiko, Fukumura, Ryutaro, Furuichi, Masato, Iwasaki, Yuki, Hokama, Masaaki, Ikemura, Toshimichi, Tsuzuki, Teruhisa, Gondo, Yoichi, Nakabeppu, Yusaku

“…Spontaneous germline mutations generate genetic diversity in populations of sexually reproductive organisms and are thus regarded as a driving force of…”
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Accumulation of Adenine DNA Glycosylase-sensitive Sites in Human Mitochondrial DNA by Miyako, Kenichi, Takamatsu, Chihiro, Umeda, Shuyo, Tajiri, Tatsurou, Furuichi, Masato, Nakabeppu, Yusaku, Sekiguchi, Mutsuo, Hamasaki, Naotaka, Takeshige, Koichiro, Kang, Dongchon

“…The mitochondrial respiratory chain inevitably produces reactive oxygen species as byproducts of aerobic ATP synthesis. Mitochondrial DNA (mtDNA), which is…”
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Regulation of Expression of the Human MTH1 Gene Encoding 8-Oxo-dGTPase by Oda, Hisanobu, Nakabeppu, Yusaku, Furuichi, Masato, Sekiguchi, Mutsuo

“…The enzyme 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase (8-oxo-dGTPase) hydrolyzes 8-oxo-dGTP to 8-oxo-dGMP, thereby preventing misincorporation of…”
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Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption by SAKUMI, Kunihiko, TOMINAGA, Yohei, FURUICHI, Masato, PING XU, TSUZUKI, Teruhisa, SEKIGUCHI, Mutsuo, NAKABEPPU, Yusaku

“…Using Mth1 and Ogg1 knockout mice, we evaluated the roles of these enzymes to prevent tumorigenesis and the accumulation of 8-oxoguanine (8-oxoG) in DNA. We…”
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A genome-wide distribution of 8-oxoguanine correlates with the preferred regions for recombination and single nucleotide polymorphism in the human genome by Ohno, Mizuki, Miura, Tomofumi, Furuichi, Masato, Tominaga, Yohei, Tsuchimoto, Daisuke, Sakumi, Kunihiko, Nakabeppu, Yusaku

“…8-Oxoguanine (8-oxoG), a major spontaneous form of oxidative DNA damage, is considered to be a natural cause of genomic diversity in organisms because of its…”
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The defense mechanisms in mammalian cells against oxidative damage in nucleic acids and their involvement in the suppression of mutagenesis and cell death by Nakabeppu, Yusaku, Tsuchimoto, Daisuke, Furuichi, Masato, Sakumi, Kunihiko

“…To counteract oxidative damage in nucleic acids, mammalian cells are equipped with several defense mechanisms. We herein review that MTH1, MUTYH and OGG1 play…”
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The GT to GC single nucleotide polymorphism at the beginning of an alternative exon 2C of human MTH1 gene confers an amino terminal extension that functions as a mitochondrial targeting signal by SAKAI, Yasunari, ODA, Hisanobu, YOSHIMURA, Daisuke, FURUICHI, Masato, KANG, Dongchon, IWAI, Shigenori, HARA, Toshiro, NAKABEPPU, Yusaku

“…Human MTH1 protein hydrolyzes oxidized purine nucleotides 8-oxo-2'-deoxyguanosine triphosphate (8-oxo-dGTP), 2-OH-dATP or their ribo-forms to their…”
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