Search Results - "Furugohri, T."

DU‐176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles by FURUGOHRI, T., ISOBE, K., HONDA, Y., KAMISATO‐MATSUMOTO, C., SUGIYAMA, N., NAGAHARA, T., MORISHIMA, Y., SHIBANO, T.

“…Background: Factor Xa (FXa), a key serine protease that converts prothrombin to thrombin in the coagulation cascade, is a promising target enzyme for the…”
Get full text

Antithrombin-independent thrombin inhibitors, but not direct factor Xa inhibitors, enhance thrombin generation in plasma through inhibition of thrombin-thrombomodulin-protein C system by Furugohri, Taketoshi, Sugiyama, Nobutoshi, Morishima, Yoshiyuki, Shibano, Toshiro

“…There is increasing concern that some anticoagulants can paradoxically increase thrombogenesis under certain circumstances. Previously, we demonstrated that at…”
Get more information

Different antithrombotic properties of factor Xa inhibitor and thrombin inhibitor in rat thrombosis models by Furugohri, Taketoshi, Shiozaki, Yoko, Muramatsu, Sumie, Honda, Yuko, Matsumoto, Chikako, Isobe, Koji, Sugiyama, Nobutoshi

“…We compared the antithrombotic properties of a factor Xa inhibitor (DX-9065a) with those of a thrombin inhibitor (melagatran) in a rat disseminated…”
Get full text

The effect of direct FXa inhibitor and direct thrombin inhibitor on TF induced DIC and venous thrombosis models in anesthetized rat - thrombin inhibitor enhance the platelet consumption in DIC model by Furugohri, T., Shiozaki, Y., Muramatsu, S., Honda, Y., Matsumoto, C., Isobe, K., Sugiyama, N.

Get full text

Asp278 of Human β-Adrenergic Receptor Kinase 1 Is Essential for Phosphorylation Activity by Iino, Minoru, Furugohri, Taketoshi, Fukuzawa, Akiko, Shibano, Toshiro

“…Asp278 of β-adrenergic receptor kinase 1 (βARK1) was suggested to play a key role in substrate recognition of β2-adrenergic receptors in our previous study, in…”
Get full text

Potent inhibitors of neutral endopeptidase. 2-Biphenyl- methylglutaric acid amide derivatives by Kanno, Hideyuki, Osanai, Ken, Furugohri, Taketoshi, Watanabe, Yoshifumi

“…A series of glutaric acid amide derivatives were synthesized and tested for NEP inhibitory activity. Compounds 14a, 14b, 16a and 22, with a biphenylmethyl…”
Get full text

Synthesis and evaluation of 2-(biphenylmethyl)glutaric acid amide derivatives as neutral endopeptidase inhibitors by Kanno, Hideyuki, Osanai, Ken, Nishi, Tatsuya, Iino, Minoru, Katakura, Shin-ichi, Furugohri, Taketoshi, Watanabe, Yoshifumi

“…A series of 2-(biphenylmethyl)glutaric acid amide derivatives were synthesized and evaluated for NEP inhibitory activity. The mode of inhibitor-enzyme…”
Get full text

Activation of glucose transport by activatory receptor agonists of adenylate cyclase in rat adipocytes by Shirakura, S, Furugohri, T, Tokumitsu, Y

“…1. Catecholamine, glucagon, and adrenocorticotropic hormone stimulated 2-deoxyglucose (2-DG) uptake via an increase in glucose transporters in plasma…”
Get more information