Search Results - "Furspan, Philip B."

Dynamic reciprocity of sodium and potassium channel expression in a macromolecular complex controls cardiac excitability and arrhythmia by Milstein, Michelle L., Musa, Hassan, Balbuena, Daniela Ponce, Anumonwo, Justus M. B., Auerbach, David S., Furspan, Philip B., Hou, Luqia, Hu, Bin, Schumacher, Sarah M., Vaidyanathan, Ravi, Martens, Jeffrey R., Jalife, José

“…The cardiac electrical impulse depends on an orchestrated interplay of transmembrane ionic currents in myocardial cells. Two critical ionic current mechanisms…”
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Structural heterogeneity promotes triggered activity, reflection and arrhythmogenesis in cardiomyocyte monolayers by Auerbach, David S., Grzȩda, Krzysztof R., Furspan, Philip B., Sato, Priscila Y., Mironov, Sergey, Jalife, José

“…Non‐technical summary  The heartbeat depends on the spread of electrical waves through the cardiac muscle. If that spread becomes disturbed, arrhythmias and…”
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Loss of H3K4 methylation destabilizes gene expression patterns and physiological functions in adult murine cardiomyocytes by Stein, Adam B, Jones, Thomas A, Herron, Todd J, Patel, Sanjeevkumar R, Day, Sharlene M, Noujaim, Sami F, Milstein, Michelle L, Klos, Matthew, Furspan, Philip B, Jalife, José, Dressler, Gregory R

“…Histone H3 lysine 4 (H3K4me) methyltransferases and their cofactors are essential for embryonic development and the establishment of gene expression patterns…”
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Decreased ATP sensitivity of a K+ channel and enhanced vascular smooth muscle relaxation in genetically hypertensive rats by Furspan, P B, Webb, R C

“…To characterize an ATP-sensitive K+ channel at the single-channel and tissue level in the vascular smooth muscle of normotensive and genetically hypertensive…”
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Calcium Current in Smooth Muscle Cells From Normotensive and Genetically Hypertensive Rats by Wilde, Dixon W, Furspan, Philip B, Szocik, James F

“…Genetic hypertension results from numerous phenotypic expressions. We hypothesized that increased calcium current in vascular smooth muscle of genetically…”
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Effect of Modulators of Protein Tyrosine Kinase Activity on Gender-Related Differences in Vascular Reactivity at Reduced Temperature by Furspan, Philip B, Freedman, Robert R

“…We used the isolated-muscle-bath technique to examine the effect of protein tyrosine kinase (PTK) and protein tyrosine phosphatase (PTP) inhibitors on the…”
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Cooling‐induced contraction in different types of smooth muscle is mediated by increased protein tyrosine kinase activity by Furspan, Philip B.

“…Many types of smooth muscle, vascular and non‐vascular, contract in response to a reduction in temperature. We have reported that the contraction by rat tail…”
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Dietary Calcium and Cell Membrane Abnormality in Genetic Hypertension by Furspan, Philip B, Rinaldi, Gustavo J, Hoffman, Kenneth, Bohr, David F

“…Adult stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar-Kyoto (WKY) rats were maintained for 10 weeks on one of two diets1.0% calcium content and…”
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Increased tyrosine phosphorylation mediates the cooling‐induced contraction and increased vascular reactivity of Raynaud's disease by Furspan, Philip B., Chatterjee, Soumya, Freedman, Robert R.

“…Objective Increased levels of protein tyrosine kinase (PTK) are mechanistically associated with increased contractile responsiveness to cooling. This study…”
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Calcium-Related Abnormalities in Lymphocytes from Genetically Hypertensive Rats by FURSPAN, PHILIP B, BOHR, DAVID F

“…We examined the effect of various external calcium concentrations on net potassium efflux and net sodium influx in lymphocytes from spontaneously hypertensive…”
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Reciprocal Modulation of Nav1.5 and kir2.1 in a Macromolecular Complex Controls Cardiac Excitability and Arrhythmias by Milstein, Michelle L., Vaidyanathan, Ravi, Furspan, Philip B., Hou, Luqia, Hu, Bin, Auerbach, David S., Anumonwo, Justus M.B., Jalife, José

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Reciprocal Modulation of Na v1.5 and kir2.1 in a Macromolecular Complex Controls Cardiac Excitability and Arrhythmias by Milstein, Michelle L., Vaidyanathan, Ravi, Furspan, Philip B., Hou, Luqia, Hu, Bin, Auerbach, David S., Anumonwo, Justus M.B., Jalife, José

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Reciprocal Modulation of Nav 1.5 and kir2.1 in a Macromolecular Complex Controls Cardiac Excitability and Arrhythmias by Milstein, Michelle L, Vaidyanathan, Ravi, Furspan, Philip B, Hou, Luqia, Hu, Bin, Auerbach, David S, Anumonwo, Justus M.B, Jalife, José

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Effects of felodipine on blood pressure and lymphocyte membrane characteristics in spontaneously hypertensive stroke-prone rats by Furspan, P B, Bohr, D F

“…Adult spontaneously hypertensive stroke-prone rats (SHRSP) and age- and sex-matched Wistar-Kyoto rats (WKY) were treated with the calcium-channel antagonist…”
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Evidence that Increased Transmural Pressure is the Main Stimulus for Vascular Remodeling by Watson, Ralph Edward, Pereira‐Hicks, Cristiane Neves, Wang, Hui, Galligan, James Joseph, Furspan, Philip B, Fink, Gregory

“…Abstract only Remodeling of arteries occurs in hypertension (HTN). Intraluminal pressure stimulates growth. Venous pressure is not increased in systemic (HTN),…”
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Genetic relationship between a lymphocyte membrane abnormality and blood pressure in spontaneously hypertensive stroke prone and Wistar-Kyoto rats by Furspan, P B, Jokelainen, P T, Sing, C F, Bohr, D F

“…The fluxes of sodium and potassium across the lymphocyte membrane in spontaneously hypertensive, stroke prone rats (SHRSP) are greater than those in…”
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Lymphocyte Abnormalities in Three Types of Hypertension in the Rat by FURSPAN, PHILIP B, BOHR, DAVID F

“…Lymphocyte number and weight and their sodium and potassium contents and net passive fluxes were measured in spontaneously hypertensive stroke-prone rats,…”
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Evolution of Neurohypophyseal Hormone Actions in Vertebrates by Peter K. T. Pang, Philip B. Furspan, Sawyer, Wilbur H.

“…Arginine vasotocin (AVT) is one neurohypophyseal principle that has been found in all vertebrates including the cyclostomes. Although many effects have been…”
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Antihypertensive action of felodipine in stroke-prone spontaneously hypertensive rats by Bohr, D F, Furspan, P B, Bruner, C A, Luong, V V, Jokelainen, P T, Webb, R C

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Effect of temperature and modulators of protein tyrosine kinase activity on the reactivity of isolated venules in secondary Raynaud's phenomenon by FURSPAN, Philip B, MAYES, Maureen D, FREEDMAN, Robert R

“…OBJECTIVE: To investigate the response of skin venules from healthy controls and scleroderma patients with Raynaud's phenomenon (RP/SSc) to cooling and to…”
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