Search Results - "Furr, Johnathan R"

Cumulative Effects of In Utero Administration of Mixtures of “Antiandrogens” on Male Rat Reproductive Development by Rider, Cynthia V., Wilson, Vickie S., Howdeshell, Kembra L., Hotchkiss, Andrew K., Furr, Johnathan R., Lambright, Christy R., Earl Gray, L.

“…Although risk assessments are typically conducted on a chemical-by-chemical basis, the 1996 Food Quality Protection Act (FQPA) required the Environmental…”
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A short-term in vivo screen using fetal testosterone production, a key event in the phthalate adverse outcome pathway, to predict disruption of sexual differentiation by Furr, Johnathan R, Lambright, Christy S, Wilson, Vickie S, Foster, Paul M, Gray, Jr, Leon E

“…This study was designed to develop and validate a short-term in vivo protocol termed the Fetal Phthalate Screen (FPS) to detect phthalate esters (PEs) and…”
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In Utero Exposure to a Mixture of the Perfluoroalkyl-Isopropyl Pesticide Pyrifluquinazon With Dibutyl Phthalate Cumulatively Disrupts Male Rat Reproductive Development via Different Mechanisms of Action by Gray, Leon Earl, Conley, Justin M, Lambright, Christy S, Furr, Johnathan R

“…Abstract Administration of individual chemicals and mixtures during sexual differentiation that disrupt the androgen signaling pathway can induce reproductive…”
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Dose Addition Models Based on Biologically Relevant Reductions in Fetal Testosterone Accurately Predict Postnatal Reproductive Tract Alterations by a Phthalate Mixture in Rats by Howdeshell, Kembra L, Rider, Cynthia V, Wilson, Vickie S, Furr, Johnathan R, Lambright, Christy R, Gray, Jr, L Earl

“…Challenges in cumulative risk assessment of anti-androgenic phthalate mixtures include a lack of data on all the individual phthalates and difficulty…”
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A Demonstration of the Uncertainty in Predicting the Estrogenic Activity of Individual Chemicals and Mixtures From an In Vitro Estrogen Receptor Transcriptional Activation Assay (T47D-KBluc) to the In Vivo Uterotrophic Assay Using Oral Exposure by Conley, Justin M, Hannas, Bethany R, Furr, Johnathan R, Wilson, Vickie S, Gray, Jr, L Earl

“…In vitro estrogen receptor assays are valuable tools for identifying environmental samples and chemicals that display estrogenic activity. However, in vitro…”
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Genomic and Hormonal Biomarkers of Phthalate-Induced Male Rat Reproductive Developmental Toxicity Part II: A Targeted RT-qPCR Array Approach That Defines a Unique Adverse Outcome Pathway by Gray, Leon Earl, Lambright, Christy S, Conley, Justin M, Evans, Nicola, Furr, Johnathan R, Hannas, Bethany R, Wilson, Vickie S, Sampson, Hunter, Foster, Paul M D

“…Abstract Previously, we demonstrated that exposure to some diortho-phthalate esters during sexual differentiation disrupts male reproductive development by…”
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Oral deoxynivalenol toxicity in Harlan Sprague Dawley (Hsd:Sprague Dawley® SD®) rat dams and their offspring by Huang, Madelyn C., Furr, Johnathan R., Robinson, Veronica G., Betz, Laura, Shockley, Keith, Cunny, Helen, Witt, Kristine, Waidyanatha, Suramya, Germolec, Dori

“…There is widespread human exposure to deoxynivalenol (DON), a fungal mycotoxin found globally in many grain-based foods and animal feed. Acute exposures to…”
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A Conflicted Tale of Two Novel AR Antagonists In Vitro and In Vivo: Pyrifluquinazon Versus Bisphenol C by Gray, Leon Earl, Furr, Johnathan R, Conley, Justin M, Lambright, Christy S, Evans, Nicola, Cardon, Mary C, Wilson, Vickie S, Foster, Paul M, Hartig, Phillip C

“…Abstract Chemicals that disrupt androgen receptor (AR) function in utero induce a cascade of adverse effects in male rats including reduced anogenital…”
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Quantification of the Uncertainties in Extrapolating From In Vitro Androgen Receptor Antagonism to In Vivo Hershberger Assay Endpoints and Adverse Reproductive Development in Male Rats by Gray, Leon E, Furr, Johnathan R, Lambright, Christy S, Evans, Nicola, Hartig, Phillip C, Cardon, Mary C, Wilson, Vickie S, Hotchkiss, Andrew K, Conley, Justin M

“…Abstract Multiple molecular initiating events exist that disrupt male sexual differentiation in utero including androgen receptor (AR) antagonism and…”
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In utero exposure to simvastatin reduces postnatal survival and permanently alters reproductive tract development in the Crl:CD(SD) male rat by Beverly, Brandiese E.J., Furr, Johnathan R., Lambright, Christy S., Wilson, Vickie S., McIntyre, Barry S., Foster, Paul M.D., Travlos, Greg, Earl Gray, L.

“…We showed previously that in utero exposure to the cholesterol-lowering drug simvastatin (SMV) during sex differentiation lowers fetal lipids and testicular…”
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Transgenerational Effects of Di (2-Ethylhexyl) Phthalate in the Male CRL:CD(SD) Rat: Added Value of Assessing Multiple Offspring per Litter by Gray, Leon Earl, Barlow, Norman J., Howdeshell, Kembra L., Ostby, Joseph S., Furr, Johnathan R., Gray, Clark L.

“…In the rat, some phthalates alter sexual differentiation at relatively low dosage levels by altering fetal Leydig cell development and hormone synthesis,…”
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Simvastatin and dipentyl phthalate lower ex vivo testicular testosterone production and exhibit additive effects on testicular testosterone and gene expression via distinct mechanistic pathways in the fetal rat by Beverly, Brandiese E J, Lambright, Christy S, Furr, Johnathan R, Sampson, Hunter, Wilson, Vickie S, McIntyre, Barry S, Foster, Paul M D, Travlos, Gregory, Gray, Jr, L Earl

“…Sex differentiation of the male reproductive tract in mammals is driven, in part, by fetal androgen production. In utero, some phthalate esters (PEs) alter…”
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The herbicide linuron reduces testosterone production from the fetal rat testis during both in utero and in vitro exposures by Wilson, Vickie S., Lambright, Christy R., Furr, Johnathan R., Howdeshell, Kembra L., Earl Gray, L.

“…In utero exposure to linuron, an urea-based herbicide, results in a pattern of malformations of androgen-dependent tissues in adult male rat offspring…”
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Simvastatin Reduces Fetal Testosterone Production and Permanently Alters Reproductive Tract Development in the Crl:CD(SD) Male Rat by Beverly, Brandiese E.J., Furr, Johnathan R., Lambright, Christy S., Wilson, Vickie S., McIntyre, Barry S., Foster, Paul M.D., Travlos, Greg, Gray, L. Earl

“…We showed previously that in utero exposure to the cholesterol-lowering drug simvastatin (SMV) during sex differentiation lowered circulating lipids and…”
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Cumulative effects of in utero administration of mixtures of reproductive toxicants that disrupt common target tissues via diverse mechanisms of toxicity by Rider, C. V., Furr, J. R., Wilson, V. S., Gray Jr, L. E.

“…Summary Although risk assessments are typically conducted on a chemical‐by‐chemical basis, the 1996 Food Quality Protection Act required the US Environmental…”
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