Search Results - "Furness, Andrew"

The evolution of an annual life cycle in killifish: adaptation to ephemeral aquatic environments through embryonic diapause by Furness, Andrew I.

“…ABSTRACT An annual life cycle is characterized by growth, maturity, and reproduction condensed into a single, short season favourable to development, with…”
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The reproductive ecology drivers of egg attendance in amphibians by Furness, Andrew I., Capellini, Isabella

“…Parental care is extremely diverse but, despite much research, why parental care evolves is poorly understood. Here we address this outstanding question using…”
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The evolution of parental care diversity in amphibians by Furness, Andrew I., Capellini, Isabella

“…Parental care is extremely diverse across species, ranging from simple behaviours to complex adaptations, varying in duration and in which sex cares…”
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Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition by Litchfield, Kevin, Reading, James L., Puttick, Clare, Thakkar, Krupa, Abbosh, Chris, Bentham, Robert, Watkins, Thomas B.K., Rosenthal, Rachel, Biswas, Dhruva, Rowan, Andrew, Lim, Emilia, Al Bakir, Maise, Turati, Virginia, Guerra-Assunção, José Afonso, Conde, Lucia, Furness, Andrew J.S., Saini, Sunil Kumar, Hadrup, Sine R., Herrero, Javier, Lee, Se-Hoon, Van Loo, Peter, Enver, Tariq, Larkin, James, Hellmann, Matthew D., Turajlic, Samra, Quezada, Sergio A., McGranahan, Nicholas, Swanton, Charles

“…Checkpoint inhibitors (CPIs) augment adaptive immunity. Systematic pan-tumor analyses may reveal the relative importance of tumor-cell-intrinsic and…”
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Impact of tumour microenvironment and Fc receptors on the activity of immunomodulatory antibodies by Furness, Andrew J.S, Vargas, Frederick Arce, Peggs, Karl S, Quezada, Sergio A

“…Highlights • FcγRs play a key role in the activity of immunomodulatory mAbs in mouse models. • αCTLA-4 expands Teff cells while selectively depleting…”
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Terrestrial reproduction and parental care drive rapid evolution in the trade-off between offspring size and number across amphibians by Furness, Andrew I, Venditti, Chris, Capellini, Isabella

“…The trade-off between offspring size and number is central to life history strategies. Both the evolutionary gain of parental care or more favorable habitats…”
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Cytokine release syndrome in a patient with colorectal cancer after vaccination with BNT162b2 by Au, Lewis, Fendler, Annika, Shepherd, Scott T. C., Rzeniewicz, Karolina, Cerrone, Maddalena, Byrne, Fiona, Carlyle, Eleanor, Edmonds, Kim, Del Rosario, Lyra, Shon, John, Haynes, Winston A., Ward, Barry, Shum, Ben, Gordon, William, Gerard, Camille L., Xie, Wenyi, Joharatnam-Hogan, Nalinie, Young, Kate, Pickering, Lisa, Furness, Andrew J. S., Larkin, James, Harvey, Ruth, Kassiotis, George, Gandhi, Sonia, Swanton, Charles, Fribbens, Charlotte, Wilkinson, Katalin A., Wilkinson, Robert J., Lau, David K., Banerjee, Susana, Starling, Naureen, Chau, Ian, Turajlic, Samra

“…Patients with cancer are currently prioritized in coronavirus disease 2019 (COVID-19) vaccination programs globally, which includes administration of mRNA…”
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Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes by Bentzen, Amalie Kai, Marquard, Andrea Marion, Lyngaa, Rikke, Saini, Sunil Kumar, Ramskov, Sofie, Donia, Marco, Such, Lina, Furness, Andrew J S, McGranahan, Nicholas, Rosenthal, Rachel, Straten, Per thor, Szallasi, Zoltan, Svane, Inge Marie, Swanton, Charles, Quezada, Sergio A, Jakobsen, Søren Nyboe, Eklund, Aron Charles, Hadrup, Sine Reker

“…Detection of more than 1,000 different T-cell specificities in parallel facilitates identification of cancer and autoimmune antigens. Identification of the…”
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Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade by McGranahan, Nicholas, Furness, Andrew J. S., Rosenthal, Rachel, Ramskov, Sofie, Lyngaa, Rikke, Saini, Sunil Kumar, Jamal-Hanjani, Mariam, Wilson, Gareth A., Birkbak, Nicolai J., Hiley, Crispin T., Watkins, Thomas B. K., Shafi, Seema, Murugaesu, Nirupa, Mitter, Richard, Akarca, Ayse U., Linares, Joseph, Marafioti, Teresa, Henry, Jake Y., Van Allen, Eliezer M., Miao, Diana, Schilling, Bastian, Schadendorf, Dirk, Garraway, Levi A., Makarov, Vladimir, Rizvi, Naiyer A., Snyder, Alexandra, Hellmann, Matthew D., Merghoub, Taha, Wolchok, Jedd D., Shukla, Sachet A., Wu, Catherine J., Peggs, Karl S., Chan, Timothy A., Hadrup, Sine R., Quezada, Sergio A., Swanton, Charles

“…As tumors grow, they acquire mutations, some of which create neoantigens that influence the response of patients to immune checkpoint inhibitors. We explored…”
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Lactate dehydrogenase as a selection criterion for ipilimumab treatment in metastatic melanoma by Kelderman, Sander, Heemskerk, Bianca, van Tinteren, Harm, van den Brom, Rob R. H., Hospers, Geke A. P., van den Eertwegh, Alfonsus J. M., Kapiteijn, Ellen W., de Groot, Jan Willem B., Soetekouw, Patricia, Jansen, Rob L., Fiets, Edward, Furness, Andrew J. S., Renn, Alexandra, Krzystanek, Marcin, Szallasi, Zoltan, Lorigan, Paul, Gore, Martin E., Schumacher, Ton N. M., Haanen, John B. A. G., Larkin, James M. G., Blank, Christian U.

“…Introduction Ipilimumab, a cytotoxic T lymphocyte-associated antigen-4 blocking antibody, has improved overall survival (OS) in metastatic melanoma in phase…”
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A cleaning interaction between sailfin mollies (Poecilia latipinna) and humans in Lake Vouliagmeni, Greece by Furness, Andrew I.

“…Here, I report an unexpected interaction between the introduced fish species, Poecilia ( Mollienesia ) latipinna and humans in Lake Vouliagmeni, Greece. In…”
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Advances in the development of tumor-infiltrating lymphocyte therapy for advanced melanoma by Julve, Max, Furness, Andrew Js

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Adaptation in a variable environment: Phenotypic plasticity and bet-hedging during egg diapause and hatching in an annual killifish by Furness, Andrew I., Lee, Kevin, Reznick, David N.

“…Two ways in which organisms adapt to variable environments are phenotypic plasticity and bet-hedging. Theory suggests that bet-hedging is expected to evolve in…”
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The origin and biogeographic diversification of fishes in the family Poeciliidae by Reznick, David N, Furness, Andrew I, Meredith, Robert W, Springer, Mark S

“…The fish subfamily Poeciliinae (sensu Parenti, 1981) is widely distributed across the Western Hemisphere and a dominant component of the fish communities of…”
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Anti-programmed cell death-1 therapy and insulin-dependent diabetes: a case report by Martin-Liberal, Juan, Furness, Andrew JS, Joshi, Kroopa, Peggs, Karl S., Quezada, Sergio A., Larkin, James

“…The anti programmed cell death-1 (PD-1) antibodies pembrolizumab and nivolumab have been recently licensed by the Food and Drug Administration for the…”
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Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer by Fendler, Annika, Shepherd, Scott T C, Au, Lewis, Wu, Mary, Harvey, Ruth, Schmitt, Andreas M, Tippu, Zayd, Shum, Benjamin, Farag, Sheima, Rogiers, Aljosja, Carlyle, Eleanor, Edmonds, Kim, Del Rosario, Lyra, Lingard, Karla, Mangwende, Mary, Holt, Lucy, Ahmod, Hamid, Korteweg, Justine, Foley, Tara, Barber, Taja, Emslie-Henry, Andrea, Caulfield-Lynch, Niamh, Byrne, Fiona, Deng, Daqi, Kjaer, Svend, Song, Ok-Ryul, Queval, Christophe, Kavanagh, Caitlin, Wall, Emma C, Carr, Edward J, Caidan, Simon, Gavrielides, Mike, MacRae, James I, Kelly, Gavin, Peat, Kema, Kelly, Denise, Murra, Aida, Kelly, Kayleigh, O'Flaherty, Molly, Shea, Robyn L, Gardner, Gail, Murray, Darren, Yousaf, Nadia, Jhanji, Shaman, Tatham, Kate, Cunningham, David, Van As, Nicholas, Young, Kate, Furness, Andrew J S, Pickering, Lisa, Beale, Rupert, Swanton, Charles, Gandhi, Sonia, Gamblin, Steve, Bauer, David L V, Kassiotis, George, Howell, Michael, Nicholson, Emma, Walker, Susanna, Larkin, James, Turajlic, Samra

“…[...]we evaluated omicron nAbT in four patients with a history of breakthrough delta infection after two vaccine doses. The exact correlates of immune…”
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Efficacy and safety of lifileucel, a one-time autologous tumor-infiltrating lymphocyte (TIL) cell therapy, in patients with advanced melanoma after progression on immune checkpoint inhibitors and targeted therapies: pooled analysis of consecutive cohorts of the C-144-01 study by Chesney, Jason, Lewis, Karl D, Kluger, Harriet, Hamid, Omid, Whitman, Eric, Thomas, Sajeve, Wermke, Martin, Cusnir, Mike, Domingo-Musibay, Evidio, Phan, Giao Q, Kirkwood, John M, Hassel, Jessica C, Orloff, Marlana, Larkin, James, Weber, Jeffrey, Furness, Andrew J S, Khushalani, Nikhil I, Medina, Theresa, Egger, Michael E, Graf Finckenstein, Friedrich, Jagasia, Madan, Hari, Parameswaran, Sulur, Giri, Shi, Wen, Wu, Xiao, Sarnaik, Amod

“…Patients with advanced melanoma have limited treatment options after progression on immune checkpoint inhibitors (ICI). Lifileucel, a one-time autologous…”
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Ipilimumab plus nivolumab in patients with symptomatic melanoma brain metastasis requiring corticosteroids by Manacorda, Simona, Carmena, Maria De Toro, Malone, Ciara, Linh Le, Ha Mo, Furness, Andrew J.S., Larkin, James, Schmitt, Andreas M.

“…To investigate the efficacy of PD-1-directed antibody-based therapy in patients with symptomatic melanoma brain metastases (MBM) and concurrent treatment with…”
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Marrow-Infiltrating Regulatory T Cells Correlate with the Presence of Dysfunctional CD4 + PD-1 + Cells and Inferior Survival in Patients with Newly Diagnosed Multiple Myeloma by Alrasheed, Nouf, Lee, Lydia, Ghorani, Ehsan, Henry, Jake Y, Conde, Lucia, Chin, Melody, Galas-Filipowicz, Daria, Furness, Andrew J S, Chavda, Selina J, Richards, Huw, De-Silva, Dunnya, Cohen, Oliver C, Patel, Dominic, Brooks, Anthony, Rodriguez-Justo, Manuel, Pule, Martin, Herrero, Javier, Quezada, Sergio A, Yong, Kwee L

“…Immune dysregulation is described in multiple myeloma. While preclinical models suggest a role for altered T-cell immunity in disease progression, the…”
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Pan-cancer deconvolution of tumour composition using DNA methylation by Chakravarthy, Ankur, Furness, Andrew, Joshi, Kroopa, Ghorani, Ehsan, Ford, Kirsty, Ward, Matthew J., King, Emma V., Lechner, Matt, Marafioti, Teresa, Quezada, Sergio A., Thomas, Gareth J., Feber, Andrew, Fenton, Tim R.

“…The nature and extent of immune cell infiltration into solid tumours are key determinants of therapeutic response. Here, using a DNA methylation-based approach…”
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