Search Results - "Furlong, Stephen"

Characterization of renal biomarkers for use in clinical trials: biomarker evaluation in healthy volunteers by Brott, David A, Adler, Scott H, Arani, Ramin, Lovick, Susan C, Pinches, Mark, Furlong, Stephen T

“…Several preclinical urinary biomarkers have been qualified and accepted by the health authorities (US Food and Drug Administration, European Medicines Agency,…”
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Recognition of a lipid antigen by GDI-restricted αβ + T cells by Beckman, Evan M, Porcelli, Steven A, Morita, Craig T, Behar, Samuel M, Furlong, Stephen T, Brenner, Michael B

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Characterization of renal biomarkers for use in clinical trials: effect of preanalytical processing and qualification using samples from subjects with diabetes by Brott, David A, Furlong, Stephen T, Adler, Scott H, Hainer, James W, Arani, Ramin B, Pinches, Mark, Rossing, Peter, Chaturvedi, Nish

“…Identifying the potential for drug-induced kidney injury is essential for the successful research and development of new drugs. Newer and more sensitive…”
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Structural requirements for glycolipid antigen recognition by CD1b-restricted T cells by MOODY, D. B, REINHOLD, B. B, BESRA, G. S, PORCELLI, S. A, GUY, M. R, BECKMAN, E. M, FREDERIQUE, D. E, FURLONG, S. T, YE, S, REINHOLD, V. N, SIELING, P. A, MODLIN, R. L

“…The human CD1b protein presents lipid antigens to T cells, but the molecular mechanism is unknown. Identification of mycobacterial glucose monomycolate (GMM)…”
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Induction of CD1-Restricted Immune Responses in Guinea Pigs by Immunization with Mycobacterial Lipid Antigens by Hiromatsu, Kenji, Dascher, Christopher C, LeClair, Kenneth P, Sugita, Masahiko, Furlong, Stephen T, Brenner, Michael B, Porcelli, Steven A

“…Group 1 CD1 molecules have been shown to present lipid and glycolipid Ags of mycobacteria to human T cells. However, a suitable animal model for the…”
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Phosphatidylcholine and Phosphatidylethanolamine Behave as Substrates of the Human MDR1 P-Glycoprotein by Bosch, Irene, Dunussi-Joannopoulos, Kyriaki, Wu, Rui-Lian, Furlong, Stephen T, Croop, James

“…The multidrug resistant cell line CEM/VBL300 and the parental CEM T-lymphoblastic cell line from which it was derived were used to study the accumulation of…”
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A view from Oxford Road: Reflections on CILIP’s 2019 conference at University of Manchester by Furlong, Stephen

“…In 2019 UKeiG was delighted to announce that the winners of two UKeiG bursary places for the CILIP Conference 2019 were Natasha Chowdory and Stephen Furlong…”
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Pretreatment data is highly predictive of liver chemistry signals in clinical trials by Cai, Zhaohui, Bresell, Anders, Steinberg, Mark H, Silberg, Debra G, Furlong, Stephen T

“…The goal of this retrospective analysis was to assess how well predictive models could determine which patients would develop liver chemistry signals during…”
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Fine Specificity of TCR Complementarity-Determining Region Residues and Lipid Antigen Hydrophilic Moieties in the Recognition of a CD1-Lipid Complex by Grant, Ethan P, Beckman, Evan M, Behar, Samuel M, Degano, Massimo, Frederique, Daphney, Besra, Gurdyal S, Wilson, Ian A, Porcelli, Steven A, Furlong, Stephen T, Brenner, Michael B

“…alphabeta TCR can recognize peptides presented by MHC molecules or lipids and glycolipids presented by CD1 proteins. Whereas the structural basis for…”
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Synthesis and physical characterization of a P1 arginine combinatorial library, and its application to the determination of the substrate specificity of serine peptidases by FURLONG, Stephen T, MAUGER, Russell C, STRIMPLER, Anne M, LIU, Yi-Ping, MORRIS, Frank X, EDWARDS, Philip D

“…Serine peptidases are a large, well-studied, and medically important class of peptidases. Despite the attention these enzymes have received, details concerning…”
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Synthesis and enzymatic evaluation of a P1 arginine aminocoumarin substrate library for trypsin-like serine proteases by EDWARDS, Philip D, MAUGER, Russell C, COTTRELL, Kevin M, MORRIS, Frank X, PINE, Kara K, SYLVESTER, Mark A, SCOTT, Clay W, FURLONG, Stephen T

“…A method for the solid-phase synthesis of P1 arginine containing peptides via attachment of the arginine side-chain guanidine group is described. This…”
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Purification, characterization and catalytic properties of human sterol 8-isomerase by Nes, W David, Zhou, Wenxu, Dennis, Allen L, Li, Haoxia, Jia, Zhonghua, Keith, Richard A, Piser, Timothy M, Furlong, Stephen T

“…CHO 2, encoding human sterol 8-isomerase (hSI), was introduced into plasmids pYX213 or pET23a. The resulting native protein was overexpressed in erg 2 yeast…”
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Current status and future perspectives of renal safety biomarkers by Pinches, Mark, Benjamin, Amanda, Furlong, Stephen, Brott, David

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Lipid Transfer from Human Epithelial Cells to Pneumocystis carinii In Vitro by Furlong, Stephen T., Koziel, Henry, Bartlett, Marilyn S., McLaughlin, Gerald L., Shaw, Margaret M., Jack, Richard M.

“…Pneumocystis carinii lipids are similar to host lipids, but it is not known if some of these lipids are acquired from host cells. The ability of P. carinii to…”
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C3 activation is inhibited by analogs of compstatin but not by serine protease inhibitors or peptidyl α-ketoheterocycles by Furlong, Stephen T, Dutta, Anand S, Coath, Matthew M, Gormley, James J, Hubbs, Stephen J, Lloyd, Darleen, Mauger, Russell C, Strimpler, Anne M, Sylvester, Mark A, Scott, Clay W, Edwards, Philip D

“…C3 convertase is a key enzyme in the complement cascade and is an attractive therapeutic target for drug design. Recent studies have demonstrated that this…”
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CD1-Restricted Microbial Lipid Antigen-Specific Recognition Found in the CD8+ αβ T Cell Pool by Rosat, Jean-Pierre, Grant, Ethan P., Beckman, Evan M., Dascher, Christopher C., Sieling, Peter A., Frederique, Daphney, Modlin, Robert L., Porcelli, Steven A., Furlong, Stephen T., Brenner, Michael B.

“…It is generally accepted that TCR αβ+ CD8+ T cells recognize immunogenic peptides bound to MHC-encoded class I molecules. This recognition is a major component…”
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A comparative study of the MATRICS and IntegNeuro cognitive assessment batteries by Silverstein, Steven M., Jaeger, Judith, Donovan-Lepore, Anne-Marie, Wilkniss, Sandra M., Savitz, Adam, Malinovsky, Igor, Hawthorne, Danielle, Raines, Shane, Carson, Sarah, Marcello, Stephanie, Zukin, Stephen R., Furlong, Stephen, Dent, Gersham

“…Cognitive impairment is prevalent in schizophrenia and is related to poorer functional and treatment outcomes. Cognitive assessment is therefore now a routine…”
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Monopalmitoylphosphatidylcholine incorporation into human erythrocyte ghost membranes causes protein and lipid immobilization and cholesterol depletion by Golan, David E, Furlong, Stephen T, Brown, Carl S, Caulfield, John P

“…The effects of lysophosphatidylcholine (lysoPC) on human erythrocyte (RBC) ghost morphology, transmembrane protein and lipid lateral mobilities, and membrane…”
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NICOTINICMODULATION OF P50 AMPLITUDE IN FIRST-DEGREE RELATIVES OF SCHIZOPHRENIA PATIENTS by Turetsky, Bruce, Hamilton, Michael, Dent, Gersham, Furlong, Stephen, Jaeger, Judith, Zukin, Stephen

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Sterols of parasitic protozoa and helminths by Furlong, S T

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