Search Results - "Furgała, Anna"

Serotonergic Neurotransmission System Modulator, Vortioxetine, and Dopaminergic D2/D3 Receptor Agonist, Ropinirole, Attenuate Fibromyalgia-Like Symptoms in Mice by Sałat, Kinga, Furgała-Wojas, Anna

“…Fibromyalgia is a disease characterized by lowered pain threshold, mood disorders, and decreased muscular strength. It results from a complex dysfunction of…”
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Interventional and preventive effects of aripiprazole and ceftriaxone used alone or in combination on oxaliplatin-induced tactile and cold allodynia in mice by Sałat, Kinga, Furgała, Anna, Sałat, Robert

“…[Display omitted] •In mice aripiprazole and ceftriaxone attenuate oxaliplatin-induced tactile allodynia.•These drugs do not reduce cold allodynia caused by…”
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The Microglial Activation Inhibitor Minocycline, Used Alone and in Combination with Duloxetine, Attenuates Pain Caused by Oxaliplatin in Mice by Sałat, Kinga, Furgała-Wojas, Anna, Sałat, Robert

“…The antitumor drug, oxaliplatin, induces neuropathic pain, which is resistant to available analgesics, and novel mechanism-based therapies are being evaluated…”
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Antinociceptive, antiallodynic and antihyperalgesic effects of the 5-HT1A receptor selective agonist, NLX-112 in mouse models of pain by Sałat, Kinga, Kołaczkowski, Marcin, Furgała, Anna, Rojek, Adriana, Śniecikowska, Joanna, Varney, Mark A., Newman-Tancredi, Adrian

“…NLX-112 (a.k.a. befiradol, F13640) is a drug candidate intended for the treatment of l-DOPA-induced dyskinesia. It is a highly selective serotonin 5-HT1A…”
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Phenylalanine-Based AMPA Receptor Antagonist as the Anticonvulsant Agent with Neuroprotective Activity-In Vitro and In Vivo Studies by Latacz, Gniewomir, Sałat, Kinga, Furgała-Wojas, Anna, Martyniak, Adrian, Olejarz-Maciej, Agnieszka, Honkisz-Orzechowska, Ewelina, Szymańska, Ewa

“…Trying to meet the multitarget-directed ligands strategy, a series of previously described aryl-substituted phenylalanine derivatives, reported as competitive…”
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Time-shifted co-administration of sub-analgesic doses of ambroxol and pregabalin attenuates oxaliplatin-induced cold allodynia in mice by Furgała, Anna, Fijałkowski, Łukasz, Nowaczyk, Alicja, Sałat, Robert, Sałat, Kinga

“…[Display omitted] •Oxaliplatin-induced cold allodynia is a pharmacoresistant painful condition.•Novel therapeutic strategies to overcome cold allodynia are…”
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Wide-Range Measurement of Thermal Preference-A Novel Method for Detecting Analgesics Reducing Thermally-Evoked Pain in Mice by Sałat, Kinga, Furgała-Wojas, Anna, Awtoniuk, Michał, Sałat, Robert

“…Wide use of oxaliplatin as an antitumor drug is limited by severe neuropathy with pharmacoresistant cold hypersensitivity as the main symptom. Novel analgesics…”
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Evaluation of cebranopadol, a dually acting nociceptin/orphanin FQ and opioid receptor agonist in mouse models of acute, tonic, and chemotherapy-induced neuropathic pain by Sałat, Kinga, Furgała, Anna, Sałat, Robert

“…Background Cebranopadol (a.k.a. GRT-6005) is a dually acting nociceptin/orphanin FQ and opioid receptor agonist that has been recently developed in Phase 2…”
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Acute cold allodynia induced by oxaliplatin is attenuated by amitriptyline by Furgała, Anna, Sałat, Robert, Sałat, Kinga

“…Oxaliplatin is a third-generation, platinum-based antitumor drug used to treat colorectal cancer. Since its main adverse effect is neuropathic pain resulting…”
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Novel GPR18 Ligands in Rodent Pharmacological Tests: Effects on Mood, Pain, and Eating Disorders by Frankowska, Małgorzata, Wydra, Karolina, Suder, Agata, Zaniewska, Magdalena, Gawliński, Dawid, Miszkiel, Joanna, Furgała-Wojas, Anna, Sałat, Kinga, Filip, Małgorzata, Müller, Christa E, Kieć-Kononowicz, Katarzyna, Kotańska, Magdalena

“…The lack of selective pharmacological tools has limited the full unraveling of G protein-coupled receptor 18 (GPR18) functions. The present study was aimed at…”
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Searching for analgesic drug candidates alleviating oxaliplatin‐induced cold hypersensitivity in mice by Sałat, Kinga, Furgała, Anna, Malikowska‐Racia, Natalia

“…Oxaliplatin is a third‐generation, platinum‐based derivative used to treat advanced colorectal cancer. Within the patient population on oxaliplatin therapy, a…”
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Synthesis and activity of di- or trisubstituted N-(phenoxyalkyl)- or N-{2-[2-(phenoxy)ethoxy]ethyl}piperazine derivatives on the central nervous system by Pańczyk, Katarzyna, Pytka, Karolina, Jakubczyk, Magdalena, Rapacz, Anna, Sałat, Kinga, Furgała, Anna, Siwek, Agata, Głuch-Lutwin, Monika, Gryboś, Anna, Słoczyńska, Karolina, Pękala, Elżbieta, Żmudzki, Paweł, Bucki, Adam, Kołaczkowski, Marcin, Żelaszczyk, Dorota, Marona, Henryk, Waszkielewicz, Anna M.

“…[Display omitted] •Presented compounds possess mainly antagonistic activity for serotonergic receptors.•Compound 9 showed 5-HT1A Ki = 5 nM, 5-HT7 Ki = 70 nM,…”
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Synthesis, biological evaluation and molecular docking studies of novel quinuclidinone derivatives as potential antimicrobial and anticonvulsant agents by Łączkowski, Krzysztof Z., Landowska, Katarzyna, Biernasiuk, Anna, Sałat, Kinga, Furgała, Anna, Plech, Tomasz, Malm, Anna

“…Synthesis and investigation of antimicrobial and anticonvulsant activity of eleven novel quinuclidinone-thiazole derivatives are presented. Among the…”
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The role of glutamatergic, GABA-ergic, and cholinergic receptors in depression and antidepressant-like effect by Pytka, Karolina, Dziubina, Anna, Młyniec, Katarzyna, Dziedziczak, Agnieszka, Żmudzka, Elżbieta, Furgała, Anna, Olczyk, Adrian, Sapa, Jacek, Filipek, Barbara

“…Depression is one of the most common mental disorders and social issue worldwide. Although there are many antidepressants available, the effectiveness of the…”
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Anticonvulsant and analgesic in neuropathic pain activity in a group of new aminoalkanol derivatives by Pańczyk, Katarzyna, Rapacz, Anna, Furgała-Wojas, Anna, Sałat, Kinga, Koczurkiewicz-Adamczyk, Paulina, Łucjanek, Martyna, Skiba-Kurek, Iwona, Karczewska, Elżbieta, Sowa, Aleksandra, Żelaszczyk, Dorota, Siwek, Agata, Popiół, Justyna, Pękala, Elżbieta, Marona, Henryk, Waszkielewicz, Anna

“…[Display omitted] As part of the presented research, thirteen new aminoalkanol derivatives were designed and obtained by chemical synthesis. In vivo studies…”
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Enhanced pharmacological efficacy of sumatriptan due to modification of its physicochemical properties by inclusion in selected cyclodextrins by Paczkowska, Magdalena, Mizera, Mikołaj, Sałat, Kinga, Furgała, Anna, Popik, Piotr, Knapik-Kowalczuk, Justyna, Krause, Anna, Szymanowska-Powałowska, Daria, Fojud, Zbigniew, Kozak, Maciej, Paluch, Marian, Cielecka-Piontek, Judyta

“…The study focused on the pharmacological action of sumatriptan, in particular its antiallodynic and antihyperalgesic properties, as an effect of cyclodextrinic…”
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Novel mouse GABA uptake inhibitors with enhanced inhibitory activity toward mGAT3/4 and their effect on pain threshold in mice by Zaręba, Paula, Gryzło, Beata, Malawska, Katarzyna, Sałat, Kinga, Höfner, Georg C., Nowaczyk, Alicja, Fijałkowski, Łukasz, Rapacz, Anna, Podkowa, Adrian, Furgała, Anna, Żmudzki, Paweł, Wanner, Klaus T., Malawska, Barbara, Kulig, Katarzyna

“…γ-Aminobutyric acid (GABA) uptake transporters are membrane transport proteins that are involved in the pathophysiology of a number of neurological disorders…”
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Synthesis, antimicrobial and anticonvulsant screening of small library of tetrahydro-2H-thiopyran-4-yl based thiazoles and selenazoles by Łączkowski, Krzysztof Z, Biernasiuk, Anna, Baranowska-Łączkowska, Angelika, Zielińska, Sylwia, Sałat, Kinga, Furgała, Anna, Misiura, Konrad, Malm, Anna

“…Synthesis and investigation of antimicrobial activity of 22 novel thiazoles and selenazoles derived from dihydro-2H-thiopyran-4(3H)-one are presented…”
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Thiazoles with cyclopropyl fragment as antifungal, anticonvulsant, and anti-Toxoplasma gondii agents: synthesis, toxicity evaluation, and molecular docking study by Łączkowski, Krzysztof Z., Konklewska, Natalia, Biernasiuk, Anna, Malm, Anna, Sałat, Kinga, Furgała, Anna, Dzitko, Katarzyna, Bekier, Adrian, Baranowska-Łączkowska, Angelika, Paneth, Agata

“…Synthesis and investigation of antifungal, anticonvulsant and anti- Toxoplasma gondii activities of ten novel (2-(cyclopropylmethylidene)hydrazinyl)thiazole 3a…”
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The Inclusion of Tolfenamic Acid into Cyclodextrins Stimulated by Microenvironmental pH Modification as a Way to Increase the Anti-Migraine Effect by Stasiłowicz, Anna, Tykarska, Ewa, Rosiak, Natalia, Sałat, Kinga, Furgała-Wojas, Anna, Plech, Tomasz, Lewandowska, Kornelia, Pikosz, Katarzyna, Pawłowicz, Kamil, Cielecka-Piontek, Judyta

“…The poorly soluble nonsteroidal anti-inflammatory drug (NSAID), tolfenamic acid (TA), was studied to maximize its solubility, permeability through biological…”
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