Search Results - "Furfine, Eric S."

Crystal Structure of an HSA/FcRn Complex Reveals Recycling by Competitive Mimicry of HSA Ligands at a pH-Dependent Hydrophobic Interface by Schmidt, Michael M., Townson, Sharon A., Andreucci, Amy J., King, Bracken M., Schirmer, Emily B., Murillo, Alec J., Dombrowski, Christian, Tisdale, Alison W., Lowden, Patricia A., Masci, Allyson L., Kovalchin, Joseph T., Erbe, David V., Wittrup, K. Dane, Furfine, Eric S., Barnes, Thomas M.

“…The long circulating half-life of serum albumin, the most abundant protein in mammalian plasma, derives from pH-dependent endosomal salvage from degradation,…”
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Design of a superior cytokine antagonist for topical ophthalmic use by Hou, Jinzhao, Townson, Sharon A., Kovalchin, Joseph T., Masci, Allyson, Kiner, Olga, Shu, Yanqun, King, Bracken M., Schirmer, Emily, Golden, Kathryn, Thomas, Christoph, Garcia, K. Christopher, Zarbis-Papastoitsis, Gregory, Furfine, Eric S., Barnes, Thomas M.

“…IL-1 is a key inflammatory and immune mediator in many diseases, including dry-eye disease, and its inhibition is clinically efficacious in rheumatoid…”
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Preclinical Development of EBI-005: An IL-1 Receptor-1 Inhibitor for the Topical Ocular Treatment of Ocular Surface Inflammatory Diseases by Kovalchin, Joseph, King, Bracken, Masci, Allyson, Hopkins, Elizabeth, Fry, Jeremy, Hou, Jay, Li, Christian, Tenneson, Kelly, Weber, Steve, Wolfe, Gary, Collins, Kathy, Furfine, Eric S

“…OBJECTIVE:Topical interleukin (IL)-1 receptor (R)1 blockade is therapeutically active in reducing signs and symptoms of dry eye disease. Herein, we describe in…”
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Anti-tumor effect of CT-322 as an Adnectin inhibitor of vascular endothelial growth factor receptor-2 by Mamluk, Roni, Carvajal, Irvith M., Morse, Brent A., Wong, Henry K, Abramowitz, Janette, Aslanian, Sharon, Lim, Ai-Ching, Gokemeijer, Jochem, Storek, Michael J., Lee, Joonsoo, Gosselin, Michael, Wright, Martin C., Camphausen, Ray T., Wang, Jack, Chen, Yan, Miller, Kathy, Sanders, Kerry, Short, Sarah, Sperinde, Jeff, Prasad, Gargi, Williams, Stephen, Kerbel, Robert S., Ebos, John, Mutsaers, Anthony, Mendlein, John D., Harris, Alan S., Furfine, Eric S.

“…CT-322 is a new anti-angiogenic therapeutic agent based on an engineered variant of the tenth type III domain of human fibronectin, i.e., an AdnectinTM,…”
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A fibronectin scaffold approach to bispecific inhibitors of epidermal growth factor receptor and insulin-like growth factor-I receptor by Emanuel, Stuart L., Engle, Linda J., Chao, Ginger, Zhu, Rong-Rong, Cao, Carolyn, Lin, Zheng, Yamniuk, Aaron P., Hosbach, Jennifer, Brown, Jennifer, Fitzpatrick, Elizabeth, Gokemeijer, Jochem, Morin, Paul, Morse, Brent A., Carvajal, Irvith M., Fabrizio, David, Wright, Martin C., Das Gupta, Ruchira, Gosselin, Michael, Cataldo, Daniel, Ryseck, Rolf P., Doyle, Michael L., Wong, Tai W., Camphausen, Raymond T., Cload, Sharon T., Marsh, H. Nicholas, Gottardis, Marco M., Furfine, Eric S.

“…Engineered domains of human fibronectin (Adnectins™) were used to generate a bispecific Adnectin targeting epidermal growth factor receptor (EGFR) and…”
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Preclinical Pharmacology and Pharmacokinetics of GW433908, a Water-Soluble Prodrug of the Human Immunodeficiency Virus Protease Inhibitor Amprenavir by FURFINE, Eric S, BAKER, Christopher T, HALE, Michael R, REYNOLDS, David J, SALISBURY, Jo A, SEARLE, Andy D, STUDENBERG, Scott D, TODD, Dan, TUNG, Roger D, SPALTENSTEIN, Andrew

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Inhibition of Wild-Type and Mutant Human Immunodeficiency Virus Type 1 Proteases by GW0385 and Other Arylsulfonamides by Hanlon, Mary H, Porter, David J. T, Furfine, Eric S, Spaltenstein, Andrew, Carter, H. Luke, Danger, Dana, Shu, Arthur Y. L, Kaldor, Istvan W, Miller, John F, Samano, Vicente A

“…The arylsulfonamide derivatives described herein were such potent inhibitors of human immunodeficiency virus type 1 (HIV-1) protease (enzyme, E) that values…”
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1400W Is a Slow, Tight Binding, and Highly Selective Inhibitor of Inducible Nitric-oxide Synthase in Vitro and in Vivo by Garvey, E P, Oplinger, J A, Furfine, E S, Kiff, R J, Laszlo, F, Whittle, B J, Knowles, R G

“…N -(3-(Aminomethyl)benzyl)acetamidine (1400W) was a slow, tight binding inhibitor of human inducible nitric- oxide synthase (iNOS). The slow onset of…”
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Effectors of HIV-1 Protease Peptidolytic Activity by Porter, David J. T, Hanlon, Mary H, Carter, Luke H, Danger, Dana P, Furfine, Eric S

“…High concentrations of salts dramatically affect the interaction of small ligands with HIV-1 protease. For instance, the K m and k cat values for…”
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Adnectin CT-322 inhibits tumor growth and affects microvascular architecture and function in Colo205 tumor xenografts by ACKERMANN, Maximilian, CARVAJAL, Irvith M, KONERDING, Moritz A, MORSE, Brent A, MORETA, Miguel, O'NEIL, Steven, KOSSODO, Sylvie, PETERSON, Jeffrey D, DELVENTHAL, Vera, MARSH, H. Nicholas, FURFINE, Eric S

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Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: The discovery of GW0385 by Miller, John F., Andrews, C. Webster, Brieger, Michael, Furfine, Eric S., Hale, Michael R., Hanlon, Mary H., Hazen, Richard J., Kaldor, Istvan, McLean, Ed W., Reynolds, David, Sammond, Douglas M., Spaltenstein, Andrew, Tung, Roger, Turner, Elizabeth M., Xu, Robert X., Sherrill, Ronald G.

“…A novel series of P1 modified HIV protease inhibitors was synthesized and evaluated for in vitro antiviral activity against wild-type virus and protease…”
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Metabolic complications associated with antiretroviral therapy by Jain, Renu G, Furfine, Eric S, Pedneault, Louise, White, Alex J, Lenhard, James M

“…Mortality rates in the HIV-infected patient population have decreased with the advent of highly active antiretroviral therapy (HAART) for the treatment of…”
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Adnectin CT-322 inhibits tumor growth and affects microvascular architecture and function in Colo205 tumor xenografts by Ackermann, Maximilian, Carvajal, Irvith M, Morse, Brent A, Moreta, Miguel, O'Neil, Steven, Kossodo, Sylvie, Peterson, Jeffrey D, Delventhal, Vera, Marsh, H Nicholas, Furfine, Eric S, Konerding, Moritz A

“…Antiangiogenesis has become a promising pillar in modern cancer therapy. This study investigates the antiangiogenic effects of the PEGylated Adnectin™, CT-322,…”
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HIV protease inhibitors block adipogenesis and increase lipolysis in vitro by Lenhard, James M, Furfine, Eric S, Jain, Renu G, Ittoop, Olivia, Orband-Miller, Lisa A, Blanchard, Steven G, Paulik, Mark A, Weiel, James E

“…AIDS therapies employing HIV protease inhibitors (PIs) are associated with changes in fat metabolism. However, the cellular mechanisms affected by PIs are not…”
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Stimulation of vitamin A1 acid signaling by the HIV protease inhibitor indinavir by LENHARD, J. M, WEIEL, J. E, PAULIK, M. A, FURFINE, E. S

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Substrate Binding Is Required for Release of Product from Mammalian Protein Farnesyltransferase by Tschantz, W R, Furfine, E S, Casey, P J

“…Protein farnesyltransferase (FTase) catalyzes the modification by a farnesyl lipid of Ras and several other key proteins involved in cellular regulation…”
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Protein farnesyltransferase: kinetics of farnesyl pyrophosphate binding and product release by Furfine, Eric S, Leban, Johann J, Landavazo, Anthony, Moomaw, John F, Casey, Patrick J

“…Protein farnesyltransferase (FTase) catalyzes the prenylation of Ras and several other key proteins involved in cell regulation. The mechanism of the FTase…”
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Novel P1 chain-extended HIV protease inhibitors possessing potent anti-HIV activity and remarkable inverse antiviral resistance profiles by Miller, John F., Brieger, Michael, Furfine, Eric S., Hazen, Richard J., Kaldor, Istvan, Reynolds, David, Sherrill, Ronald G., Spaltenstein, Andrew

“…A novel series of tyrosine-derived HIV protease inhibitors was synthesized and evaluated for in vitro antiviral activity against wild-type virus and two…”
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N-Phenylamidines as Selective Inhibitors of Human Neuronal Nitric Oxide Synthase:  Structure−Activity Studies and Demonstration of in Vivo Activity by Collins, Jon L, Shearer, Barry G, Oplinger, Jeffrey A, Lee, Shuliang, Garvey, Edward P, Salter, Mark, Duffy, Claire, Burnette, Thimysta C, Furfine, Eric S

“…Selective inhibition of the neuronal isoform of nitric oxide synthase (NOS) compared to the endothelial and inducible isoforms may be required for treatment of…”
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Novel arylsulfonamides possessing sub-picomolar HIV protease activities and potent anti-HIV activity against wild-type and drug-resistant viral strains by MILLER, John F, FURFINE, Eric S, HANLON, Mary H, HAZEN, Richard J, RAY, John A, ROBINSON, Laurence, SAMANO, Vicente, SPALTENSTEIN, Andrew

“…A novel series of P1' chain-extended arylsufonamides was synthesized and evaluated for wild-type HIV protease inhibitory activity and in vitro antiviral…”
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