Search Results - "Funk, Gregory D."

On the existence of a central respiratory oxygen sensor by Gourine, Alexander V, Funk, Gregory D

“…A commonly held view that dominates both the scientific and educational literature is that in terrestrial mammals the central nervous system lacks a…”
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The rhythmic, transverse medullary slice preparation in respiratory neurobiology: Contributions and caveats by Funk, Gregory D, Greer, John J

“…Highlights ► We describe the rhythmic medullary slice preparation and variations of it. ► We review key contributions that have resulted from the analysis of…”
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State-dependent modulation of breathing in urethane-anesthetized rats by Pagliardini, Silvia, Greer, John J, Funk, Gregory D, Dickson, Clayton T

“…Respiratory activity is most fragile during sleep, in particular during paradoxical [or rapid eye movement (REM)] sleep and sleep state transitions. Rats are…”
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Ampakine CX717 Protects against Fentanyl-induced Respiratory Depression and Lethal Apnea in Rats by JUN REN, XIUQING DING, FUNK, Gregory D, GREER, John J

“…The use of fentanyl as a potent analgesic is contradicted by marked respiratory depression among a subpopulation of patients. The commonly used approach of…”
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Breathing and brain state: Urethane anesthesia as a model for natural sleep by Pagliardini, Silvia, Funk, Gregory D, Dickson, Clayton T

“…Highlights • Spontaneous brain state alternations occur under urethane anesthesia. • State alternations under urethane resemble the natural sleep cycle. •…”
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Commentary: Acute perturbation of Pet1 -neuron activity in neonatal mice impairs cardiorespiratory homeostatic recovery by Funk, Gregory D, Biancardi, Vivian

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Anxiety-related mechanisms of respiratory dysfunction in a mouse model of Rett syndrome by Ren, Jun, Ding, Xiuqing, Funk, Gregory D, Greer, John J

“…Rett syndrome (RTT) is a severe neurological disorder that is associated with mutations in the methyl-CpG binding protein 2 (MECP2) gene. RTT patients suffer…”
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Dbx1 precursor cells are a source of inspiratory XII premotoneurons by Revill, Ann L, Vann, Nikolas C, Akins, Victoria T, Kottick, Andrew, Gray, Paul A, Del Negro, Christopher A, Funk, Gregory D

“…All behaviors require coordinated activation of motoneurons from central command and premotor networks. The genetic identities of premotoneurons providing…”
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Muscarinic acetylcholine receptors enhance neonatal mouse hypoglossal motoneuron excitability in vitro by Ireland, Matthew F, Funk, Gregory D, Bellingham, Mark C

“…In brain stem slices from neonatal (postnatal days 0-4) CD-1 mice, muscarinic ACh receptors (MAChRs) increased rhythmic inspiratory-related and tonic…”
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KCNQ Current Contributes to Inspiratory Burst Termination in the Pre-Bötzinger Complex of Neonatal Rats in vitro by Revill, Ann L, Katzell, Alexis, Del Negro, Christopher A, Milsom, William K, Funk, Gregory D

“…The pre-Bötzinger complex (preBötC) of the ventral medulla generates the mammalian inspiratory breathing rhythm. When isolated in explants and deprived of…”
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Laser ablation of Dbx1 neurons in the pre-Bötzinger complex stops inspiratory rhythm and impairs output in neonatal mice by Wang, Xueying, Hayes, John A, Revill, Ann L, Song, Hanbing, Kottick, Andrew, Vann, Nikolas C, LaMar, M Drew, Picardo, Maria Cristina D, Akins, Victoria T, Funk, Gregory D, Del Negro, Christopher A

“…To understand the neural origins of rhythmic behavior one must characterize the central pattern generator circuit and quantify the population size needed to…”
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Breathing matters by Del Negro, Christopher A., Funk, Gregory D., Feldman, Jack L.

“…Breathing is a well-described, vital and surprisingly complex behaviour, with behavioural and physiological outputs that are easy to directly measure. Key…”
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CrossTalk proposal: a central hypoxia sensor contributes to the excitatory hypoxic ventilatory response by Funk, Gregory D, Gourine, Alexander V

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High Sensitivity to Neuromodulator-Activated Signaling Pathways at Physiological [K+] of Confocally Imaged Respiratory Center Neurons in On-Line-Calibrated Newborn Rat Brainstem Slices by Ruangkittisakul, Araya, Schwarzacher, Stephan W, Secchia, Lucia, Poon, Betty Y, Ma, Yonglie, Funk, Gregory D, Ballanyi, Klaus

“…The pre-Bötzinger complex (PBC) inspiratory center remains active in a transverse brainstem slice. Such slices are studied at high (8-10 mM) superfusate [K+],…”
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Opiate-induced suppression of rat hypoglossal motoneuron activity and its reversal by ampakine therapy by Lorier, Amanda R, Funk, Gregory D, Greer, John J

“…Hypoglossal (XII) motoneurons innervate tongue muscles and are vital for maintaining upper-airway patency during inspiration. Depression of XII nerve activity…”
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Glia Contribute to the Purinergic Modulation of Inspiratory Rhythm-Generating Networks by Huxtable, Adrianne G, Zwicker, Jennifer D, Alvares, Tucaaue S, Ruangkittisakul, Araya, Fang, Xin, Hahn, Leanne B, Posse de Chaves, Elena, Baker, Glen B, Ballanyi, Klaus, Funk, Gregory D

“…Glia modulate neuronal activity by releasing transmitters in a process called gliotransmission. The role of this process in controlling the activity of…”
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Release of ATP by pre‐Bötzinger complex astrocytes contributes to the hypoxic ventilatory response via a Ca2+‐dependent P2Y1 receptor mechanism by Rajani, Vishaal, Zhang, Yong, Jalubula, Venkatesh, Rancic, Vladimir, SheikhBahaei, Shahriar, Zwicker, Jennifer D., Pagliardini, Silvia, Dickson, Clayton T., Ballanyi, Klaus, Kasparov, Sergey, Gourine, Alexander V., Funk, Gregory D.

“…Key points The ventilatory response to reduced oxygen (hypoxia) is biphasic, comprising an initial increase in ventilation followed by a secondary depression…”
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Synaptic Control of Motoneuronal Excitability by Rekling, Jens C, Funk, Gregory D, Bayliss, Douglas A, Dong, Xiao-Wei, Feldman, Jack L

“…Departments of Neurobiology and Physiological Science, University of California, Los Angeles, California; Department of Physiology, University of Auckland,…”
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The Purinome and the preBötzinger Complex - A Ménage of Unexplored Mechanisms That May Modulate/Shape the Hypoxic Ventilatory Response by Reklow, Robert J, Alvares, Tucaaue S, Zhang, Yong, Miranda Tapia, Ana P, Biancardi, Vivian, Katzell, Alexis K, Frangos, Sara M, Hansen, Megan A, Toohey, Alexander W, Cass, Carol E, Young, James D, Pagliardini, Silvia, Boison, Detlev, Funk, Gregory D

“…Exploration of purinergic signaling in brainstem homeostatic control processes is challenging the traditional view that the biphasic hypoxic ventilatory…”
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Generation of Eupnea and Sighs by a Spatiochemically Organized Inspiratory Network by Ruangkittisakul, Araya, Schwarzacher, Stephan W, Secchia, Lucia, Ma, Yonglie, Bobocea, Nicoleta, Poon, Betty Y, Funk, Gregory D, Ballanyi, Klaus

“…The discovery of the rhythmogenic pre-Bötzinger complex (preBötC) inspiratory network, which remains active in a transverse brainstem slice, greatly increased…”
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