Search Results - "Funk, Alexander M"

Oxidation of hyperpolarized [1‐13C]pyruvate in isolated rat kidneys by Sharma, Gaurav, Maptue, Nesmine, Rahim, Mohsin, Trigo Mijes, Miriam L., Hever, Thomas, Wen, Xiaodong, Funk, Alexander M., Malloy, Craig R., Young, Jamey D., Khemtong, Chalermchai

“…Kidneys play a central role in numerous disorders but current imaging methods have limited utility to probe renal metabolism. Hyperpolarized (HP) 13C magnetic…”
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Critical analysis of the limitations of Bleaney's theory of magnetic anisotropy in paramagnetic lanthanide coordination complexes by Funk, Alexander M, Finney, Katie-Louise N A, Harvey, Peter, Kenwright, Alan M, Neil, Emily R, Rogers, Nicola J, Kanthi Senanayake, P, Parker, David

“…The origins of the breakdown of Bleaney's theory of magnetic anisotropy are described, based on an analysis of eleven different complexes of the second half of…”
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Tumour catabolism independent of malnutrition and inflammation in upper GI cancer patients revealed by longitudinal metabolomics by Renesse, Janusz, Bechtolsheim, Felix, Jonas, Sophie, Seifert, Lena, Alves, Tiago C., Seifert, Adrian M., Komorek, Filip, Tritchkova, Guergana, Menschikowski, Mario, Bork, Ulrich, Meisterfeld, Ronny, Distler, Marius, Chavakis, Triantafyllos, Weitz, Jürgen, Funk, Alexander M., Kahlert, Christoph, Mirtschink, Peter

“…Background The detrimental impact of malnutrition and cachexia in cancer patients subjected to surgical resection is well established. However, how systemic…”
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Isostructural Series of Nine-Coordinate Chiral Lanthanide Complexes Based on Triazacyclononane by Walton, James W, Carr, Rachel, Evans, Nicholas H, Funk, Alexander M, Kenwright, Alan M, Parker, David, Yufit, Dmitry S, Botta, Mauro, De Pinto, Sara, Wong, Ka-Leung

“…Nonadentate ligands based on triazacyclononane incorporating pyridyl-2-phosphinate groups form an isostructural series of complexes with Ln ions in the solid…”
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Imaging Extracellular Lactate In Vitro and In Vivo Using CEST MRI and a Paramagnetic Shift Reagent by Zhang, Lei, Martins, André F., Mai, Yuyan, Zhao, Piyu, Funk, Alexander M., Clavijo Jordan, M. Veronica, Zhang, Shanrong, Chen, Wei, Wu, Yunkou, Sherry, A. Dean

“…Overproduction of lactate is a hallmark of cancer, yet a method to quantitatively measure lactate production by cancer cells is not straight‐forward. Chemical…”
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Rational Design of [13C,D14]Tert‐butylbenzene as a Scaffold Structure for Designing Long‐lived Hyperpolarized 13C Probes by Imakura, Yuki, Nonaka, Hiroshi, Takakusagi, Yoichi, Ichikawa, Kazuhiro, Maptue, Nesmine R., Funk, Alexander M., Khemtong, Chalermchai, Sando, Shinsuke

“…Dynamic nuclear polarization (DNP) is a technique to polarize the nuclear spin population. As a result of the hyperpolarization, the NMR sensitivity of the…”
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Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo by Courtney, Kevin D., Bezwada, Divya, Mashimo, Tomoyuki, Pichumani, Kumar, Vemireddy, Vamsidhara, Funk, Alexander M., Wimberly, Jennifer, McNeil, Sarah S., Kapur, Payal, Lotan, Yair, Margulis, Vitaly, Cadeddu, Jeffrey A., Pedrosa, Ivan, DeBerardinis, Ralph J., Malloy, Craig R., Bachoo, Robert M., Maher, Elizabeth A.

“…Clear cell renal cell carcinoma (ccRCC) is the most common form of human kidney cancer. Histological and molecular analyses suggest that ccRCCs…”
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Esterase-Catalyzed Production of Hyperpolarized 13C‑Enriched Carbon Dioxide in Tissues for Measuring pH by Maptue, Nesmine, Jiang, Weina, Harrison, Crystal, Funk, Alexander M, Sharma, Gaurav, Malloy, Craig R, Sherry, Dean, Khemtong, Chalermchai

“…13C Magnetic resonance imaging of hyperpolarized (HP) 13C-enriched bicarbonate (H13CO3 –) and carbon dioxide (13CO2) is a novel and sensitive technique for…”
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Cover Image, Volume 36, Issue 3 by Sharma, Gaurav, Maptue, Nesmine, Rahim, Mohsin, Trigo Mijes, Miriam L., Hever, Thomas, Wen, Xiaodong, Funk, Alexander M., Malloy, Craig R., Young, Jamey D., Khemtong, Chalermchai

“…The cover image is based on the Research Article Oxidation of hyperpolarized [1‐13C]pyruvate in isolated rat kidneys by Gaurav Sharma et al.,…”
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Circulating Dickkopf1 Parallels Metabolic Adaptations and Predicts Disease Trajectories in Patients With COVID-19 by Jaschke, Nikolai P, Funk, Alexander M, Jonas, Sophie, Riffel, Romy M, Sinha, Anupam, Wang, Andrew, Pählig, Sophie, Hofmann, Maura, Altmann, Heidi, Von Bonin, Simone, Koch, Thea, Spieth, Peter, Tausche, Kristin, Akgün, Katja, Rauner, Martina, Kronstein-Wiedemann, Romy, Odendahl, Marcus, Tonn, Torsten, Göbel, Andy, Hofbauer, Lorenz C, Rachner, Tilman D

“…Coronavirus disease 19 (COVID-19) trajectories show high interindividual variability, ranging from asymptomatic manifestations to fatal outcomes, the latter of…”
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Direct and selective tagging of cysteine residues in peptides and proteins with 4-nitropyridyl lanthanide complexes by Gempf, Kathryn L, Butler, Stephen J, Funk, Alexander M, Parker, David

“…A cysteine-selective tagging method in water is reported, based on rapid displacement of a pyridyl nitro-substituent in simple pyridines and lanthanide…”
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A Frequency‐Selective pH‐Responsive paraCEST Agent by Ratnakar, S. James, Chirayil, Sara, Funk, Alexander M., Zhang, Shanrong, Queiró, João F., Geraldes, Carlos F. G. C., Kovacs, Zoltan, Sherry, A. Dean

“…Paramagnetic chemical exchange saturation transfer (paraCEST) agents are well‐suited for imaging tissue pH because the basis of CEST, chemical exchange, is…”
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A new paramagnetically shifted imaging probe for MRI by Senanayake, P. Kanthi, Rogers, Nicola J., Finney, Katie‐Louise N.A., Harvey, Peter, Funk, Alexander M., Wilson, J. Ian, O'Hogain, Dara, Maxwell, Ross, Parker, David, Blamire, Andrew M.

“…Purpose To develop and characterize a new paramagnetic contrast agent for molecular imaging by MRI. Methods A contrast agent was developed for direct MRI…”
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Oxidative Conversion of a Europium(II)-Based T1 Agent into a Europium(III)-Based paraCEST Agent that can be Detected In Vivo by Magnetic Resonance Imaging by Funk, Alexander M., Clavijo Jordan, Veronica, Sherry, A. Dean, Ratnakar, S. James, Kovacs, Zoltan

“…The EuII complex of 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid (DOTA) tetra(glycinate) has a higher reduction potential than most EuII chelates…”
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Lanthanide DO3A‐Tropone Complexes: Efficient Dual MR/NIR Imaging Probes in Aqueous Medium by Hashami, Zohreh, Martins, Andre F., Funk, Alexander M., Jordan, Veronica Clavijo, Petoud, Stéphane, Eliseeva, Svetlana V., Kovacs, Zoltan

“…In this work, we describe a novel DOTA (1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid) based ligand with a chromophoric tropone coordinating sidearm…”
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Experimental Measurement and Theoretical Assessment of Fast Lanthanide Electronic Relaxation in Solution with Four Series of Isostructural Complexes by Funk, Alexander M, Fries, Pascal H, Harvey, Peter, Kenwright, Alan M, Parker, David

“…The rates of longitudinal relaxation for ligand nuclei in four isostructural series of lanthanide­(III) complexes have been measured by solution state NMR at…”
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The rate of lactate production from glucose in hearts is not altered by per-deuteration of glucose by Funk, Alexander M., Anderson, Brian L., Wen, Xiaodong, Hever, Thomas, Khemtong, Chalermchai, Kovacs, Zoltan, Sherry, A. Dean, Malloy, Craig R.

“…[Display omitted] •New isotopomers methods developed to investigate deuterium kinetic isotope effects using 13C NMR.•Mixture of glucoses used in perfused rat…”
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Electrochemical Investigation of the Eu3+/2+ Redox Couple in Complexes with Variable Numbers of Glycinamide and Acetate Pendant Arms by Burnett, Marianne E., Adebesin, Bukola, Funk, Alexander M., Kovacs, Zoltan, Sherry, A. Dean, Ekanger, Levi A., Allen, Matthew J., Green, Kayla N., Ratnakar, S. James

“…The Eu3+/2+ redox couple provides a convenient design platform for responsive pO2 sensors for magnetic resonance imaging (MRI). Specifically, the Eu2+ ion…”
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Front Cover: Lanthanide DO3A‐Tropone Complexes: Efficient Dual MR/NIR Imaging Probes in Aqueous Medium (Eur. J. Inorg. Chem. 43/2017) by Hashami, Zohreh, Martins, Andre F., Funk, Alexander M., Jordan, Veronica Clavijo, Petoud, Stéphane, Eliseeva, Svetlana V., Kovacs, Zoltan

“…The Front Cover shows, at the center, the structure of a DOTA‐based ligand with a tropone coordinating sidearm. The ligand forms monohydrated lanthanide…”
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Lanthanide DO3A‐Tropone Complexes: Efficient Dual MR/NIR Imaging Probes in Aqueous Medium by Hashami, Zohreh, Martins, Andre F., Funk, Alexander M., Jordan, Veronica Clavijo, Petoud, Stéphane, Eliseeva, Svetlana V., Kovacs, Zoltan

“…Invited for the cover of this issue are the groups of Zoltan Kovacs from the University of Texas Southwestern Medical Center, USA, and Svetlana Eliseeva from…”
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