Search Results - "Fung, Steven"

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    The synthesis of oligonucleotides containing an aliphatic amino group at the 5′ terminus: synthesis of fluorescent DNA primers for use in DNA sequence analysis by Smith, Lloyd M., Fung, Steven, Hunkapiller, Michael W., Hunkapiller, Tim J., Hood, Leroy E.

    Published in Nucleic acids research (11-04-1985)
    “…A rapid and versatile method has been developed for the synthesis of oligonucleotides which contain an aliphatic amino group at their 5′ terminus. This amino…”
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    Adamantane 11-β-HSD-1 inhibitors: Application of an isocyanide multicomponent reaction by Sorensen, Bryan, Rohde, Jeff, Wang, Jiahong, Fung, Steven, Monzon, Katina, Chiou, William, Pan, Liping, Deng, Xiaoqing, Stolarik, DeAnne, Frevert, Ernst U., Jacobson, Peer, Link, J.T.

    Published in Bioorganic & medicinal chemistry letters (01-12-2006)
    “…The synthesis of the potent and selective h-11-β-HSD-1 inhibitor 11 ( K i = 8 nm) is reported. A series of potent and selective adamantane aminoamide…”
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    Synthesis and structural activity relationship of 11β-HSD1 inhibitors with novel adamantane replacements by Yeh, Vince S.C., Kurukulasuriya, Ravi, Madar, David, Patel, Jyoti R., Fung, Steven, Monzon, Katina, Chiou, William, Wang, Jiahong, Jacobson, Peer, Sham, Hing L., Link, J.T.

    Published in Bioorganic & medicinal chemistry letters (15-10-2006)
    “…A series of structurally novel and metabolically stable bridged bicyclic carbocycle and heterocycle adamantane replacements have been synthesized and…”
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    Synthesis and biological evaluation of heterocycle containing adamantane 11β-HSD1 inhibitors by Yeh, Vince S.C., Patel, Jyoti R., Yong, Hong, Kurukulasuriya, Ravi, Fung, Steven, Monzon, Katina, Chiou, William, Wang, Jiahong, Stolarik, Deanne, Imade, Hovis, Beno, David, Brune, Michael, Jacobson, Peer, Sham, Hing, Link, J.T.

    Published in Bioorganic & medicinal chemistry letters (15-10-2006)
    “…A series of metabolically stable adamantane amide 11β-HSD1 inhibitors have been synthesized and biologically evaluated. These compounds exhibit excellent HSD1…”
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    Discovery of potent and selective inhibitors of 11β-HSD1 for the treatment of metabolic syndrome by Richards, Steven, Sorensen, Bryan, Jae, Hwan-soo, Winn, Marty, Chen, Yixian, Wang, Jiahong, Fung, Steven, Monzon, Katina, Frevert, Ernst U., Jacobson, Peer, Sham, Hing, Link, J.T.

    Published in Bioorganic & medicinal chemistry letters (15-12-2006)
    “…High throughput screening efforts have identified a novel class of dichloroaniline amide 11β-HSD1 inhibitors. SAR studies initiated from dichloroaniline 4…”
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    Discovery of orally active butyrolactam 11β-HSD1 inhibitors by Yeh, Vince S.C., Kurukulasuriya, Ravi, Fung, Steven, Monzon, Katina, Chiou, William, Wang, Jiahong, Stolarik, Deanne, Imade, Hovis, Shapiro, Robin, Knourek-Segel, Victoria, Bush, Eugene, Wilcox, Denise, Nguyen, Phong T., Brune, Michael, Jacobson, Peer, Link, J.T.

    Published in Bioorganic & medicinal chemistry letters (01-11-2006)
    “…A series of metabolically stable butyrolactam 11β-HSD1 inhibitors have been synthesized and biologically evaluated. A series of metabolically stable…”
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    Journal Article
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    Discovery of potent and selective inhibitors of 11beta-HSD1 for the treatment of metabolic syndrome by Richards, Steven, Sorensen, Bryan, Jae, Hwan-Soo, Winn, Marty, Chen, Yixian, Wang, Jiahong, Fung, Steven, Monzon, Katina, Frevert, Ernst U, Jacobson, Peer, Sham, Hing, Link, J T

    Published in Bioorganic & medicinal chemistry letters (15-12-2006)
    “…High throughput screening efforts have identified a novel class of dichloroaniline amide 11beta-HSD1 inhibitors. SAR studies initiated from dichloroaniline 4…”
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    Journal Article
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    Synthesis and structural activity relationship of 11beta-HSD1 inhibitors with novel adamantane replacements by Yeh, Vince S C, Kurukulasuriya, Ravi, Madar, David, Patel, Jyoti R, Fung, Steven, Monzon, Katina, Chiou, William, Wang, Jiahong, Jacobson, Peer, Sham, Hing L, Link, J T

    Published in Bioorganic & medicinal chemistry letters (15-10-2006)
    “…A series of structurally novel and metabolically stable bridged bicyclic carbocycle and heterocycle adamantane replacements have been synthesized and…”
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    Journal Article
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    Synthesis and activity of novel bile-acid conjugated glucocorticoid receptor antagonists by Richards, Steven J., von Geldern, Thomas W., Jacobson, Peer, Wilcox, Denise, Nguyen, Phong, Öhman, Lars, Österlund, Marie, Gelius, Birgitta, Grynfarb, Marlena, Goos-Nilsson, Annika, Wang, Jiahong, Fung, Steven, Kalmanovich, Masha

    Published in Bioorganic & medicinal chemistry letters (01-12-2006)
    “…A series of potent steroidal glucocorticoid receptor antagonists has been discovered. After conjugation to cholic acid, the compounds retained an affinity for…”
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    Discovery of orally active butyrolactam 11beta-HSD1 inhibitors by Yeh, Vince S C, Kurukulasuriya, Ravi, Fung, Steven, Monzon, Katina, Chiou, William, Wang, Jiahong, Stolarik, Deanne, Imade, Hovis, Shapiro, Robin, Knourek-Segel, Victoria, Bush, Eugene, Wilcox, Denise, Nguyen, Phong T, Brune, Michael, Jacobson, Peer, Link, J T

    Published in Bioorganic & medicinal chemistry letters (01-11-2006)
    “…A series of metabolically stable butyrolactam 11beta-HSD1 inhibitors have been synthesized and biologically evaluated. These compounds exhibit excellent HSD1…”
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    Journal Article
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    Synthesis and biological evaluation of heterocycle containing adamantane 11beta-HSD1 inhibitors by Yeh, Vince S C, Patel, Jyoti R, Yong, Hong, Kurukulasuriya, Ravi, Fung, Steven, Monzon, Katina, Chiou, William, Wang, Jiahong, Stolarik, Deanne, Imade, Hovis, Beno, David, Brune, Michael, Jacobson, Peer, Sham, Hing, Link, J T

    Published in Bioorganic & medicinal chemistry letters (15-10-2006)
    “…A series of metabolically stable adamantane amide 11beta-HSD1 inhibitors have been synthesized and biologically evaluated. These compounds exhibit excellent…”
    Get full text
    Journal Article