Search Results - "Fung, Kim Y. C."

A review of the potential mechanisms for the lowering of colorectal oncogenesis by butyrate by Fung, Kim Y. C., Cosgrove, Leah, Lockett, Trevor, Head, Richard, Topping, David L.

“…Colorectal cancer (CRC) is a leading cause of preventable cancer deaths worldwide, with dietary factors being recognised as key risk modifiers. Foods…”
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Blood-based protein biomarker panel for the detection of colorectal cancer by Fung, Kim Y C, Tabor, Bruce, Buckley, Michael J, Priebe, Ilka K, Purins, Leanne, Pompeia, Celine, Brierley, Gemma V, Lockett, Trevor, Gibbs, Peter, Tie, Jeanne, McMurrick, Paul, Moore, James, Ruszkiewicz, Andrew, Nice, Edouard, Adams, Timothy E, Burgess, Antony, Cosgrove, Leah J

“…The majority of colorectal cancer (CRC) cases are preventable by early detection and removal of precancerous polyps. Even though CRC is the second most common…”
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Butyrate-Induced Apoptosis in HCT116 Colorectal Cancer Cells Includes Induction of a Cell Stress Response by Fung, Kim Y. C, Brierley, Gemma V, Henderson, Steve, Hoffmann, Peter, McColl, Shaun R, Lockett, Trevor, Head, Richard, Cosgrove, Leah

“…Short chain fatty acids (SCFA), principally butyrate, propionate, and acetate, are produced in the gut through the fermentation of dietary fiber by the colonic…”
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Practical quantitative biomedical applications of MALDI-TOF mass spectrometry by Bucknall, Martin, Fung, Kim Y.C., Duncan, Mark W.

“…Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOFMS) is used to obtain fast and accurate determinations of molecular…”
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Colorectal cancer biomarkers: To be or not to be? Cautionary tales from a road well travelled by Fung, Kim Y C, Nice, Edouard, Priebe, Ilka, Belobrajdic, Damien, Phatak, Aloke, Purins, Leanne, Tabor, Bruce, Pompeia, Celine, Lockett, Trevor, Adams, Timothy E, Burgess, Antony, Cosgrove, Leah

“…Colorectal cancer(CRC)is the second most common cause of cancer-related death worldwide and places a major economic burden on the global health care system.The…”
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Ex Vivo Intestinal Organoid Models: Current State-of-the-Art and Challenges in Disease Modelling and Therapeutic Testing for Colorectal Cancer by Randall-Demllo, Sarron, Al-Qadami, Ghanyah, Raposo, Anita E, Ma, Chenkai, Priebe, Ilka K, Hor, Maryam, Singh, Rajvinder, Fung, Kim Y. C

“…Despite improvements in participation in population-based screening programme, colorectal cancer remains a major cause of cancer-related mortality worldwide…”
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Epigenetic liquid biopsies for minimal residual disease, what's around the corner? by Johnston, Andrew D, Ross, Jason P, Ma, Chenkai, Fung, Kim Y C, Locke, Warwick J

“…Liquid biopsy assays for minimal residual disease (MRD) are used to monitor and inform oncological treatment and predict the risk of relapse in cancer…”
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Characterization of the in vivo forms of lacrimal-specific proline-rich proteins in human tear fluid by Fung, Kim Y. C., Morris, Carol, Sathe, Sonal, Sack, Robert, Duncan, Mark W.

“…The tear film is complex and is rich in both peptides and proteins. Physiological factors have been shown to alter the balance of the protein components in the…”
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Colorectal carcinogenesis: a cellular response to sustained risk environment by Fung, Kim Y C, Ooi, Cheng Cheng, Zucker, Michelle H, Lockett, Trevor, Williams, Desmond B, Cosgrove, Leah J, Topping, David L

“…The current models for colorectal cancer (CRC) are essentially linear in nature with a sequential progression from adenoma through to carcinoma. However, these…”
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A simple and inexpensive approach to interfacing high-performance liquid chromatography and matrix-assisted laser desorption/ionization-time of flight-mass spectrometry by Fung, Kim Y. C., Askovic, Srdjan, Basile, Franco, Duncan, Mark W.

“…The ability to obtain the accurate mass of a protein in a complex sample mixture aids in determining its correct in vivo form. This is important when…”
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DNA Methylation Cancer Biomarkers: Translation to the Clinic by Locke, Warwick J, Guanzon, Dominic, Ma, Chenkai, Liew, Yi Jin, Duesing, Konsta R, Fung, Kim Y C, Ross, Jason P

“…Carcinogenesis is accompanied by widespread DNA methylation changes within the cell. These changes are characterized by a globally hypomethylated genome with…”
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Identification of Potential Pathways Involved in Induction of Apoptosis by Butyrate and 4‑Benzoylbutyrate in HT29 Colorectal Cancer Cells by Fung, Kim Y. C, Ooi, Cheng Cheng, Lewanowitsch, Tanya, Tan, Sandra, Tan, Hwee Tong, Lim, Teck Kwang, Lin, Qingsong, Williams, Desmond B, Lockett, Trevor J, Cosgrove, Leah J, Chung, Maxey C. M, Head, Richard J

“…Butyrate and its analogues have long been investigated as potential chemotherapeutic agents. Our previous structure–activity relationship studies of butyrate…”
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Proteomic Analysis of Butyrate Effects and Loss of Butyrate Sensitivity in HT29 Colorectal Cancer Cells by Fung, Kim Y. C, Lewanowitsch, Tanya, Henderson, Steven T, Priebe, Ilka, Hoffmann, Peter, McColl, Shaun R, Lockett, Trevor, Head, Richard, Cosgrove, Leah J

“…Butyrate, a fermentation product of the large bowel microflora, is potentially protective against the development of colorectal cancer. In vitro, butyrate has…”
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combined free-flow electrophoresis and DIGE approach to identify proteins regulated by butyrate in HT29 cells by Fung, Kim Y.C, Cursaro, Chris, Lewanowitsch, Tanya, Brierley, Gemma V, McColl, Shaun R, Lockett, Trevor, Head, Richard, Hoffmann, Peter, Cosgrove, Leah

“…Many biologically active agents exert a pleiotropic response in cells and tissues. This presents challenges in descriptive and comparative analysis of the…”
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Oncomicrobial Community Profiling Identifies Clinicomolecular and Prognostic Subtypes of Colorectal Cancer by Mouradov, Dmitri, Greenfield, Paul, Li, Shan, In, Eun-Jung, Storey, Claire, Sakthianandeswaren, Anuratha, Georgeson, Peter, Buchanan, Daniel D., Ward, Robyn L., Hawkins, Nicholas J., Skinner, Iain, Jones, Ian T., Gibbs, Peter, Ma, Chenkai, Liew, Yi Jin, Fung, Kim Y.C., Sieber, Oliver M.

“…Dysbiosis of gut microbiota is linked to the development of colorectal cancer (CRC). However, microbiota-based stratification of CRC tissue and how this…”
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Performance of serum lipocalin 2 as a diagnostic marker for colorectal cancer by Fung, Kim Y C, Priebe, Ilka, Purins, Leanne, Tabor, Bruce, Brierley, Gemma V, Lockett, Trevor, Nice, Edouard, Gibbs, Peter, Tie, Jeannie, McMurrick, Paul, Moore, James, Ruszkiewicz, Andrew, Burgess, Antony, Cosgrove, Leah J

“…Lipocalin 2 has been implicated in colorectal tumorigenesis but its usefulness as a diagnostic marker for the disease has previously never been determined. We…”
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Interactive Feature Finding in Liquid Chromatography Mass Spectrometry Data by Clifford, David, Buckley, Michael, Fung, Kim Y. C, Cosgrove, Leah

“…We propose a method for finding features in liquid chromatography mass spectrometry data that is based on the isotopic pattern of peaks. Our interactive…”
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Nutrigenetics and Nutrigenomics: Viewpoints on the Current Status and Applications in Nutrition Research and Practice by Fenech, Michael, El-Sohemy, Ahmed, Cahill, Leah, Ferguson, Lynnette R., French, Tapaeru-Ariki C., Tai, E. Shyong, Milner, John, Koh, Woon-Puay, Xie, Lin, Zucker, Michelle, Buckley, Michael, Cosgrove, Leah, Lockett, Trevor, Fung, Kim Y.C., Head, Richard

“…Nutrigenetics and nutrigenomics hold much promise for providing better nutritional advice to the public generally, genetic subgroups and individuals. Because…”
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Tumour-specific phosphorylation of serine 419 drives alpha-enolase (ENO1) nuclear export in triple negative breast cancer progression by Marshall, Morgan L, Fung, Kim Yc, Jans, David A, Wagstaff, Kylie M

“…The glycolytic enzyme alpha-enolase is a known biomarker of many cancers and involved in tumorigenic functions unrelated to its key role in glycolysis. Here,…”
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Activation of Erythropoietin Receptor through a Novel Extracellular Binding Site by Naranda, Tatjana, Kaufman, R. Ilene, Li, Jin, Wong, Kenneth, Boge, Annegret, Hallén, Dan, Fung, Kim Y. C, Duncan, Mark W, Andersen, Niels, Goldstein, Avram, Olsson, Lennart

“…Activation of erythropoietin (EPO) receptor (EPOR) by a small peptide (ERP) was reported previously. ERP binds to a different receptor site than EPO, and…”
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