Search Results - "Fung, Jennifer C"

Steroid hormones regulate genome-wide epigenetic programming and gene transcription in human endometrial cells with marked aberrancies in endometriosis by Houshdaran, Sahar, Oke, Ashwini B, Fung, Jennifer C, Vo, Kim Chi, Nezhat, Camran, Giudice, Linda C

“…Programmed cellular responses to cycling ovarian-derived steroid hormones are central to normal endometrial function. Abnormalities therein, as in the…”
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Modeling cell biological features of meiotic chromosome pairing to study interlock resolution by Navarro, Erik J, Marshall, Wallace F, Fung, Jennifer C

“…During meiosis, homologous chromosomes become associated side by side in a process known as homologous chromosome pairing. Pairing requires long range…”
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Integrity of the yeast mitochondrial genome, but not its distribution and inheritance, relies on mitochondrial fission and fusion by Osman, Christof, Noriega, Thomas R., Okreglak, Voytek, Fung, Jennifer C., Walter, Peter

“…Mitochondrial DNA (mtDNA) is essential for mitochondrial and cellular function. InSaccharomyces cerevisiae,mtDNA is organized in nucleoprotein structures…”
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Reduced Crossover Interference and Increased ZMM-Independent Recombination in the Absence of Tel1/ATM by Anderson, Carol M, Oke, Ashwini, Yam, Phoebe, Zhuge, Tangna, Fung, Jennifer C

“…Meiotic recombination involves the repair of double-strand break (DSB) precursors as crossovers (COs) or noncrossovers (NCOs). The proper number and…”
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Controlling meiotic recombinational repair - specifying the roles of ZMMs, Sgs1 and Mus81/Mms4 in crossover formation by Oke, Ashwini, Anderson, Carol M, Yam, Phoebe, Fung, Jennifer C

“…Crossovers (COs) play a critical role in ensuring proper alignment and segregation of homologous chromosomes during meiosis. How the cell balances…”
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Network Rewiring of Homologous Recombination Enzymes during Mitotic Proliferation and Meiosis by Wild, Philipp, Susperregui, Aitor, Piazza, Ilaria, Dörig, Christian, Oke, Ashwini, Arter, Meret, Yamaguchi, Miyuki, Hilditch, Alexander T., Vuina, Karla, Chan, Ki Choi, Gromova, Tatiana, Haber, James E., Fung, Jennifer C., Picotti, Paola, Matos, Joao

“…Homologous recombination (HR) is essential for high-fidelity DNA repair during mitotic proliferation and meiosis. Yet, context-specific modifications must…”
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DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation by Sousa Martins, Joao P, Liu, Xueqing, Oke, Ashwini, Arora, Ripla, Franciosi, Federica, Viville, Stephan, Laird, Diana J, Fung, Jennifer C, Conti, Marco

“…Meiotic progression requires exquisitely coordinated translation of maternal messenger (m)RNA that has accumulated during oocyte growth. A major regulator of…”
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Mitochondrial Network Size Scaling in Budding Yeast by Rafelski, Susanne M., Viana, Matheus P., Zhang, Yi, Chan, Yee-Hung M., Thorn, Kurt S., Yam, Phoebe, Fung, Jennifer C., Li, Hao, da F. Costa, Luciano, Marshall, Wallace F.

“…Mitochondria must grow with the growing cell to ensure proper cellular physiology and inheritance upon division. We measured the physical size of mitochondrial…”
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High-resolution restoration of 3D structures from widefield images with extreme low signal-to-noise-ratio by Arigovindan, Muthuvel, Fung, Jennifer C., Elnatan, Daniel, Mennella, Vito, Chan, Yee-Hung Mark, Pollard, Michael, Branlund, Eric, Sedat, John W., Agard, David A.

“…Four-dimensional fluorescence microscopy—which records 3D image information as a function of time—provides an unbiased way of tracking dynamic behavior of…”
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Global Analysis of the Meiotic Crossover Landscape by Chen, Stacy Y., Tsubouchi, Tomomi, Rockmill, Beth, Sandler, Jay S., Richards, Daniel R., Vader, Gerben, Hochwagen, Andreas, Roeder, G. Shirleen, Fung, Jennifer C.

“…Tight control of the number and distribution of crossovers is of great importance for meiosis. Crossovers establish chiasmata, which are physical connections…”
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Follicle dynamics and global organization in the intact mouse ovary by Faire, Mehlika, Skillern, Amanda, Arora, Ripla, Nguyen, Daniel H., Wang, Jason, Chamberlain, Chester, German, Michael S., Fung, Jennifer C., Laird, Diana J.

“…Quantitative analysis of tissues and organs can reveal large-scale patterning as well as the impact of perturbations and aging on biological architecture. Here…”
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Down-regulation of Rad51 activity during meiosis in yeast prevents competition with Dmc1 for repair of double-strand breaks by Liu, Yan, Gaines, William A, Callender, Tracy, Busygina, Valeria, Oke, Ashwini, Sung, Patrick, Fung, Jennifer C, Hollingsworth, Nancy M

“…Interhomolog recombination plays a critical role in promoting proper meiotic chromosome segregation but a mechanistic understanding of this process is far from…”
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Modeling meiotic chromosome pairing: nuclear envelope attachment, telomere-led active random motion, and anomalous diffusion by Marshall, Wallace F, Fung, Jennifer C

“…The recognition and pairing of homologous chromosomes during meiosis is a complex physical and molecular process involving a combination of polymer dynamics…”
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Kinetic analysis of synaptonemal complex dynamics during meiosis of yeast Saccharomyces cerevisiae reveals biphasic growth and abortive disassembly by Pollard, Michael G, Rockmill, Beth, Oke, Ashwini, Anderson, Carol M, Fung, Jennifer C

“…The synaptonemal complex (SC) is a dynamic structure formed between chromosomes during meiosis which stabilizes and supports many essential meiotic processes…”
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A High-Throughput Method for Quantifying Drosophila Fecundity by Gomez, Andreana, Gonzalez, Sergio, Oke, Ashwini, Luo, Jiayu, Duong, Johnny B, Esquerra, Raymond M, Zimmerman, Thomas, Capponi, Sara, Fung, Jennifer C, Nystul, Todd G

“…The fruit fly, , is an experimentally tractable model system that has recently emerged as a powerful "new approach methodology" (NAM) for chemical safety…”
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High throughput sequencing reveals alterations in the recombination signatures with diminishing Spo11 activity by Rockmill, Beth, Lefrançois, Philippe, Voelkel-Meiman, Karen, Oke, Ashwini, Roeder, G Shirleen, Fung, Jennifer C

“…Spo11 is the topoisomerase-like enzyme responsible for the induction of the meiosis-specific double strand breaks (DSBs), which initiates the recombination…”
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ReCombine: a suite of programs for detection and analysis of meiotic recombination in whole-genome datasets by Anderson, Carol M, Chen, Stacy Y, Dimon, Michelle T, Oke, Ashwini, DeRisi, Joseph L, Fung, Jennifer C

“…In meiosis, the exchange of DNA between chromosomes by homologous recombination is a critical step that ensures proper chromosome segregation and increases…”
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Imposition of Crossover Interference through the Nonrandom Distribution of Synapsis Initiation Complexes by Fung, Jennifer C, Rockmill, Beth, Odell, Michael, Roeder, G.Shirleen

“…Meiotic crossovers (COs) are nonrandomly distributed along chromosomes such that two COs seldom occur close together, a phenomenon known as CO interference. We…”
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Modeling homologous chromosome recognition via nonspecific interactions by Marshall, Wallace F, Fung, Jennifer C

“…In many organisms, most notably , homologous chromosomes associate in somatic cells, a phenomenon known as somatic pairing, which takes place without double…”
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The Sgs1 Helicase Regulates Chromosome Synapsis and Meiotic Crossing Over by Rockmill, Beth, Fung, Jennifer C., Branda, Steven S., Roeder, G.Shirleen

“…Background: In budding yeast, Sgs1 is the sole member of the RecQ family of DNA helicases. Like the human Bloom syndrome helicase (BLM), Sgs1 functions during…”
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