Search Results - "Fung, Eric T"

A Recipe for Proteomics Diagnostic Test Development: The OVA1 Test, from Biomarker Discovery to FDA Clearance by FUNG, Eric T

“…In particular, women with a high likelihood of malignancy could benefit from referral to specialist surgeons (e.g., gynecologic oncologists), who would be able…”
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Blood-based tests for multicancer early detection (PATHFINDER): a prospective cohort study by Schrag, Deb, Beer, Tomasz M, McDonnell, Charles H, Nadauld, Lincoln, Dilaveri, Christina A, Reid, Robert, Marinac, Catherine R, Chung, Karen C, Lopatin, Margarita, Fung, Eric T, Klein, Eric A

“…Multicancer early detection (MCED) blood tests can detect a cancer signal from circulating cell-free DNA (cfDNA). PATHFINDER was a prospective cohort study…”
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Ovarian malignancy risk stratification of the adnexal mass using a multivariate index assay by Bristow, Robert E, Smith, Alan, Zhang, Zhen, Chan, Daniel W, Crutcher, Gillian, Fung, Eric T, Munroe, Donald G

“…Abstract Objective To validate the effectiveness of a multivariate index assay in identifying ovarian malignancy compared to clinical assessment and CA125-II,…”
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Three biomarkers identified from serum proteomic analysis for the detection of early stage ovarian cancer by ZHEN ZHANG, BAST, Robert C, BERCHUCK, Andrew, VAN HAAFTEN-DAY, Carolien, HACKER, Neville F, DE BRUIJN, Henk W. A, VAN DER ZEE, Ate G. J, JACOBS, Ian J, FUNG, Eric T, CHAN, Daniel W, YINHUA YU, JINONG LI, SOKOLL, Lori J, RAI, Alex J, ROSENZWEIG, Jason M, CAMERON, Bonnie, WANG, Young Y, MENG, Xiao-Ying

“…Early detection remains the most promising approach to improve long-term survival of patients with ovarian cancer. In a five-center case-control study, serum…”
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Clinical performance of a multivariate index assay for detecting early-stage ovarian cancer by Longoria, Teresa C., MD, Ueland, Frederick R., MD, Zhang, Zhen, PhD, Chan, Daniel W., PhD, Smith, Alan, MS, Fung, Eric T., PhD, Munroe, Donald G., PhD, Bristow, Robert E., MD, MBA

“…Objective We sought to analyze the effectiveness of a multivariate index assay (MIA) in identifying early-stage ovarian malignancy compared to clinical…”
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Proteomic biomarkers apolipoprotein A1, truncated transthyretin and connective tissue activating protein III enhance the sensitivity of CA125 for detecting early stage epithelial ovarian cancer by Clarke, Charlotte H, Yip, Christine, Badgwell, Donna, Fung, Eric T, Coombes, Kevin R, Zhang, Zhen, Lu, Karen H, Bast, Robert C

“…Abstract Objective The low prevalence of ovarian cancer demands both high sensitivity (> 75%) and specificity (99.6%) to achieve a positive predictive value of…”
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A framework for evaluating biomarkers for early detection: validation of biomarker panels for ovarian cancer by Zhu, Claire S, Pinsky, Paul F, Cramer, Daniel W, Ransohoff, David F, Hartge, Patricia, Pfeiffer, Ruth M, Urban, Nicole, Mor, Gil, Bast, Jr, Robert C, Moore, Lee E, Lokshin, Anna E, McIntosh, Martin W, Skates, Steven J, Vitonis, Allison, Zhang, Zhen, Ward, David C, Symanowski, James T, Lomakin, Aleksey, Fung, Eric T, Sluss, Patrick M, Scholler, Nathalie, Lu, Karen H, Marrangoni, Adele M, Patriotis, Christos, Srivastava, Sudhir, Buys, Saundra S, Berg, Christine D

“…A panel of biomarkers may improve predictive performance over individual markers. Although many biomarker panels have been described for ovarian cancer, few…”
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Impact of a multivariate index assay on referral patterns for surgical management of an adnexal mass by Bristow, Robert E., MD, MBA, Hodeib, Melissa, DO, Smith, Alan, Chan, Daniel W., PhD, Zhang, Zhen, PhD, Fung, Eric T., MD, PhD, Tewari, Krishnansu S., MD, Munroe, Donald G., PhD, Ueland, Frederick R., MD

“…Objective To determine the impact on referral patterns of using a Multivariate Index Assay, CA125, modified-American College of Obstetricians and Gynecologists…”
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Independent Validation of Candidate Breast Cancer Serum Biomarkers Identified by Mass Spectrometry by Li, Jinong, Orlandi, Rosaria, White, C. Nicole, Rosenzweig, Jason, Zhao, Jing, Seregni, Ettore, Morelli, Daniele, Yu, Yinhua, Meng, Xiao-Ying, Zhang, Zhen, Davidson, Nancy E, Fung, Eric T, Chan, Daniel W

“…We previously selected a panel of 3 breast cancer biomarkers (BC1, BC2, and BC3) from serum samples collected at a single hospital based on their collective…”
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Classification of cancer types by measuring variants of host response proteins using SELDI serum assays by Fung, Eric T., Yip, Tai‐Tung, Lomas, Lee, Wang, Zheng, Yip, Christine, Meng, Xiao‐Ying, Lin, Shanhua, Zhang, Fujun, Zhang, Zhen, Chan, Daniel W., Weinberger, Scot R.

“…Protein expression profiling has been increasingly used to discover and characterize biomarkers that can be used for diagnostic, prognostic or therapeutic…”
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ProteinChip® Clinical Proteomics: Computational Challenges and Solutions by Eric T. Fung, Cynthia Enderwick

“…ProteinChip® technology, a suite of analytical tools that includes retentate chromatography, on-chip protein characterization, and multivariate analysis,…”
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Evaluation of Apolipoprotein A1 and Posttranslationally Modified Forms of Transthyretin as Biomarkers for Ovarian Cancer Detection in an Independent Study Population by MOORE, Lee E, FUNG, Eric T, PFEIFFER, Ruth M, MCGUIRE, Marielena, RABKIN, Charles C, MOLINARO, Annette, ZHENG WANG, FUJUN ZHANG, JING WANG, YIP, Christine, MENG, Xiao-Ying

“…Background: Although overall 5-year survival rates for ovarian cancer are poor (10-30%), stage I/IIa patients have a 95% 5-year survival. New biomarkers that…”
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Serum proteome profiling detects myelodysplastic syndromes and identifies CXC chemokine ligands 4 and 7 as markers for advanced disease by Aivado, Manuel, Spentzos, Dimitrios, Germing, Ulrich, Alterovitz, Gil, Meng, Xiao-Ying, Grall, Franck, Giagounidis, Aristoteles A.N, Klement, Giannoula, Steidl, Ulrich, Otu, Hasan H, Czibere, Akos, Prall, Wolf C, Iking-Konert, Christof, Shayne, Michelle, Ramoni, Marco F, Gattermann, Norbert, Haas, Rainer, Mitsiades, Constantine S, Fung, Eric T, Libermann, Towia A

“…Myelodysplastic syndromes (MDS) are among the most frequent hematologic malignancies. Patients have a short survival and often progress to acute myeloid…”
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Prognostic Significance of Blood-Based Multi-cancer Detection in Plasma Cell-Free DNA by Chen, Xiaoji, Dong, Zhao, Hubbell, Earl, Kurtzman, Kathryn N, Oxnard, Geoffrey R, Venn, Oliver, Melton, Collin, Clarke, Christina A, Shaknovich, Rita, Ma, Ting, Meixiong, Gerry, Seiden, Michael V, Klein, Eric A, Fung, Eric T, Liu, Minetta C

“…We recently reported the development of a cell-free DNA (cfDNA) targeted methylation (TM)-based sequencing approach for a multi-cancer early detection (MCED)…”
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Disseminated Medulloblastoma in a Child with Germline BRCA2 6174delT Mutation and without Fanconi Anemia by Xu, Jingying, Margol, Ashley Sloane, Shukla, Anju, Ren, Xiuhai, Finlay, Jonathan L, Krieger, Mark D, Gilles, Floyd H, Couch, Fergus J, Aziz, Meraj, Fung, Eric T, Asgharzadeh, Shahab, Barrett, Michael T, Erdreich-Epstein, Anat

“…Medulloblastoma, the most common malignant brain tumor in children, occurs with increased frequency in individuals with Fanconi anemia who have biallelic…”
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Protein biochips for differential profiling by Fung, Eric T, Thulasiraman, Vanitha, Weinberger, Scot R, Dalmasso, Enrique A

“…Progress has been made in utilizing ProteinChip ® technology to profile and compare protein expression in normal and diseased states, particularly in the areas…”
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Evaluation of cell-free DNA approaches for multi-cancer early detection by Jamshidi, Arash, Liu, Minetta C., Klein, Eric A., Venn, Oliver, Hubbell, Earl, Beausang, John F., Gross, Samuel, Melton, Collin, Fields, Alexander P., Liu, Qinwen, Zhang, Nan, Fung, Eric T., Kurtzman, Kathryn N., Amini, Hamed, Betts, Craig, Civello, Daniel, Freese, Peter, Calef, Robert, Davydov, Konstantin, Fayzullina, Saniya, Hou, Chenlu, Jiang, Roger, Jung, Byoungsok, Tang, Susan, Demas, Vasiliki, Newman, Joshua, Sakarya, Onur, Scott, Eric, Shenoy, Archana, Shojaee, Seyedmehdi, Steffen, Kristan K., Nicula, Virgil, Chien, Tom C., Bagaria, Siddhartha, Hunkapiller, Nathan, Desai, Mohini, Dong, Zhao, Richards, Donald A., Yeatman, Timothy J., Cohn, Allen L., Thiel, David D., Berry, Donald A., Tummala, Mohan K., McIntyre, Kristi, Sekeres, Mikkael A., Bryce, Alan, Aravanis, Alexander M., Seiden, Michael V., Swanton, Charles

“…In the Circulating Cell-free Genome Atlas (NCT02889978) substudy 1, we evaluate several approaches for a circulating cell-free DNA (cfDNA)-based multi-cancer…”
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Ovarian cyst fluid is a rich proteome resource for detection of new tumor biomarkers by Kristjansdottir, Björg, Partheen, Karolina, Fung, Eric T, Marcickiewicz, Janusz, Yip, Christine, Brännström, Mats, Sundfeldt, Karin

“…We aimed to investigate the use of ovarian cyst fluid as a source for biomarker discovery and to find novel biomarkers for use in the diagnosis of epithelial…”
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S352 Detection of Gastrointestinal Cancer in Individuals Without Clinical Suspicion of Cancer Using a Multi-Cancer Early Detection Test in the PATHFINDER Study by McDonnell, Charles H., DIlaveri, Christina A., Lopatin, Margarita, Fung, Eric T., Klein, Eric A., Karlitz, Jordan J.

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The PATHFINDER Study: Assessment of the Implementation of an Investigational Multi-Cancer Early Detection Test into Clinical Practice by Nadauld, Lincoln D, McDonnell, 3rd, Charles H, Beer, Tomasz M, Liu, Minetta C, Klein, Eric A, Hudnut, Andrew, Whittington, Richard A, Taylor, Bruce, Oxnard, Geoffrey R, Lipson, Jafi, Lopatin, Margarita, Shaknovich, Rita, Chung, Karen C, Fung, Eric T, Schrag, Deborah, Marinac, Catherine R

“…To examine the extent of the evaluation required to achieve diagnostic resolution and the test performance characteristics of a targeted methylation cell-free…”
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