Search Results - "Funel, N"

Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia by Maftouh, M, Avan, A, Sciarrillo, R, Granchi, C, Leon, L G, Rani, R, Funel, N, Smid, K, Honeywell, R, Boggi, U, Minutolo, F, Peters, G J, Giovannetti, E

“…Background: Hypoxia is a driving force in pancreatic-ductal-adenocarcinoma (PDAC) growth, metastasis and chemoresistance. The muscle-isoform of lactate…”
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Role of proton-coupled folate transporter in pemetrexed resistance of mesothelioma: clinical evidence and new pharmacological tools by Giovannetti, E., Zucali, P.A., Assaraf, Y.G., Funel, N., Gemelli, M., Stark, M., Thunnissen, E., Hou, Z., Muller, I.B., Struys, E.A., Perrino, M., Jansen, G., Matherly, L.H., Peters, G.J.

“…Thymidylate synthase (TS) has a predictive role in pemetrexed treatment of mesothelioma; however, additional chemoresistance mechanisms are poorly understood…”
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Focal adhesion kinase inhibition synergizes with nab-paclitaxel to target pancreatic ductal adenocarcinoma by Le Large, T Y S, Bijlsma, M F, El Hassouni, B, Mantini, G, Lagerweij, T, Henneman, A A, Funel, N, Kok, B, Pham, T V, de Haas, R, Morelli, L, Knol, J C, Piersma, S R, Kazemier, G, van Laarhoven, H W M, Giovannetti, E, Jimenez, C R

“…Pancreatic ductal adenocarcinoma (PDAC) is a very lethal disease, with minimal therapeutic options. Aberrant tyrosine kinase activity influences tumor growth…”
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The good, the bad and the ugly: a tale of miR-101, miR-21 and miR-155 in pancreatic intraductal papillary mucinous neoplasms by Caponi, S., Funel, N., Frampton, A.E., Mosca, F., Santarpia, L., Van der Velde, A.G., Jiao, L.R., De Lio, N., Falcone, A., Kazemier, G., Meijer, G.A., Verheul, H.M., Vasile, E., Peters, G.J., Boggi, U., Giovannetti, E.

“…This multicenter study evaluated three candidate microRNAs (miRNAs) (miR-21, miR-155 and miR-101) as potential biomarkers in intraductal papillary mucinous…”
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NSC631570 affects MMP9, HENT1, and SPARC expression in cell cultures of pancreatic cancer. Can we use it in combination with gemcitabine/nab-paclitaxel? by Funel, N., Pollina, L., Ricci, C., Palmeri, M., Di Franco, G., Morelli, L.

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Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma by Esposito, I, Menicagli, M, Funel, N, Bergmann, F, Boggi, U, Mosca, F, Bevilacqua, G, Campani, D

“…Background: Inflammatory cells contribute to the growth and spread of human malignancies by producing molecules that enhance tumour invasiveness. Aims: To…”
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Histopathologic evaluation of liver metastases from colorectal cancer in patients treated with FOLFOXIRI plus bevacizumab by Loupakis, F, Schirripa, M, Caparello, C, Funel, N, Pollina, L, Vasile, E, Cremolini, C, Salvatore, L, Morvillo, M, Antoniotti, C, Marmorino, F, Masi, G, Falcone, A

“…Background: The FOLFOXIRI regimen produces a high rate of radiological and histopathological responses. Bevacizumab added to chemotherapy showed an improvement…”
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MET as a potential target for the treatment of upper gastrointestinal cancers: characterization of novel c-Met inhibitors from bench to bedside by Avan, A, Maftouh, M, Funel, N, Ghayour-Mobarhan, M, Boggi, U, Peters, G J, Giovannetti, E

“…The receptor tyrosine kinase mesenchymal-epithelial transition factor (c-Met) plays a pivotal role in regulation of cell proliferation and migration. Abnormal…”
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Co-expression analysis of pancreatic cancer proteome reveals biology and prognostic biomarkers by Mantini, G., Vallés, A. M., Le Large, T. Y. S., Capula, M., Funel, N., Pham, T. V., Piersma, S. R., Kazemier, G., Bijlsma, M. F., Giovannetti, E., Jimenez, C. R.

“…Purpose Despite extensive biological and clinical studies, including comprehensive genomic and transcriptomic profiling efforts, pancreatic ductal…”
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Prognostic factors for pancreatic neuroendocrine neoplasms (pNET) and the risk of small non-functioning pNET by Lombardi, M., De Lio, N., Funel, N., Sardella, C., Russo, D., Urbani, C., Rossi, G., Campani, D., Martino, E., Marcocci, C., Boggi, U., Bogazzi, F.

“…Background Non-functioning (NF) pancreatic neuroendocrine tumors (pNET) often have an indolent outcome. A consensus to submit patients with large (>2 cm)…”
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Zebrafish embryos as avatar of patients with pancreatic cancer: preliminary results of validation a new model toward personalized medicine by Di Franco, G., Usai, A., Palmeri, M., Gianardi, D., Furbetta, N., Guadagni, S., Bianchini, M., Pollina, L., Funel, N., Vasile, E., Falcone, A., Raffa, V., Morelli, L.

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Co-expression analysis of proteomics data reveal tumor biology and prognostic biomarkers for pancreatic ductal adenocarcinoma by Mantini, G., Vallès, A., Capula, M., Funel, N., Le Large, T., Pham, T., Piersma, S., Kazemier, G., Bijlsma, M., Jimenez, C., Giovannetti, E.

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Treatment strategy for pancreatic IPMNs: prognostic impact of conservative surgery by Palmeri, M., Funel, N., Gianardi, D., Furbetta, N., Di Franco, G., Guadagni, S., Bianchini, M., Fatucchi, L., Cappelli, G., Asta, V., Mastrangelo, M., Pollina, L., Di Candio, G., Morelli, L.

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The biology of regulatory pathways of miRNAs, mRNAs and proteins unravels a specific -omics network in tumor-educated platelets from pancreatic cancer patients by Capula, M., Mantini, G., Meijer, L., Le Large, T., Kazemier, G., Veld G., In T., Boyd, L., Di Franco, G., Funel, N., Palmeri, M., Morelli, L., Wurdinger, T., Jimenez, C., Koppers, D., Giovannetti, E.

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Impact of phospho-Akt expression on the clinical outcome and activity of gemcitabine and Akt inhibitors in pancreatic ductal adenocarcinoma by Massihnia, D., Funel, N., Leon, L., Castiglia, M., Perez, A., Barraco, N., Listì, A., Galvano, A., Passiglia, F., Guarini, A., Calò, V., Rizzo, S., Castellana, L., Giovannetti, E., Russo, A.

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Does thyroid peroxidase provide an antigenic link between thyroid autoimmunity and breast cancer? by Muller, I., Giani, C., Zhang, L., Grennan‐Jones, F.A., Fiore, E., Belardi, V., Rosellini, V., Funel, N., Campani, D., Giustarini, E., Lewis, M.D., Bakhsh, A.D., Roncella, M., Ghilli, M., Vitti, P., Dayan, C.M., Ludgate, M.E.

“…Women with breast cancer (BC) and antithyroid peroxidase (TPO) autoantibodies (TPOAb) have a better prognosis than women lacking TPOAb. Sera from women with…”
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Phospho-Akt: a potential resistance marker to chemotherapy and therapy-target to restore sensitivity in pancreatic cancer by Giovannetti, E, Massihnia, D, Avan, A, Funel, N, Maftouh, M, Van Krieken, A, Granchi, C, Raktoe, R, Boggi, U, Aicher, B, Minutolo, F, Russo, A, Leon, L, Peters, G

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Adjuvant chemotherapy seems beneficial for invasive intraductal papillary mucinous neoplasms by Caponi, S, Vasile, E, Funel, N, De Lio, N, Campani, D, Ginocchi, L, Lucchesi, M, Caparello, C, Lencioni, M, Cappelli, C, Costa, F, Pollina, L, Ricci, S, Mosca, F, Falcone, A, Boggi, U

“…Abstract Aims The incidence of intraductal papillary mucinous neoplasm (IPMN) is rising and these neoplasms now represent up to 25% of resected pancreatic…”
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Ectopic expression of FSH receptor isoforms in neoplastic but not in endothelial cells from pancreatic neuroendocrine tumors by Sardella, C., Russo, D., Raggi, F., Lombardi, M., Urbani, C., Brogioni, S., Boggi, U., Funel, N., Chifenti, B., Campani, D., Fanelli, G., Marchetti, P., Basolo, F., Locci, M. T., Martino, E., Bogazzi, F.

“…FSH receptor (FSHR) expression is restricted to gonads, where it drives FSH-dependent cell differentiation; in addition, FSHR plays an important role in the…”
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Persistent correction of hyperglycemia in streptozotocin-nicotinamide-induced diabetic mice by a non-conventional radical scavenger by Novelli, M., Bonamassa, B., Masini, M., Funel, N., Canistro, D., De Tata, V., Martano, M., Soleti, A., Campani, D., Paolini, M., Masiello, P.

“…We previously reported that in a diabetes mouse model, characterised by moderate hyperglycaemia and reduced β-cell mass, the radical scavenger…”
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