Search Results - "Fulton, Sasha L."

Dopaminylation of histone H3 in ventral tegmental area regulates cocaine seeking by Lepack, Ashley E, Werner, Craig T, Stewart, Andrew F, Fulton, Sasha L, Zhong, Ping, Farrelly, Lorna A, Smith, Alexander C W, Ramakrishnan, Aarthi, Lyu, Yang, Bastle, Ryan M, Martin, Jennifer A, Mitra, Swarup, O'Connor, Richard M, Wang, Zi-Jun, Molina, Henrik, Turecki, Gustavo, Shen, Li, Yan, Zhen, Calipari, Erin S, Dietz, David M, Kenny, Paul J, Maze, Ian

“…Vulnerability to relapse during periods of attempted abstinence from cocaine use is hypothesized to result from the rewiring of brain reward circuitries,…”
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Histone serotonylation in dorsal raphe nucleus contributes to stress- and antidepressant-mediated gene expression and behavior by Al-Kachak, Amni, Di Salvo, Giuseppina, Fulton, Sasha L., Chan, Jennifer C, Farrelly, Lorna A., Lepack, Ashley E., Bastle, Ryan M., Kong, Lingchun, Cathomas, Flurin, Newman, Emily L., Menard, Caroline, Ramakrishnan, Aarthi, Safovich, Polina, Lyu, Yang, Covington, Herbert E., Shen, Li, Gleason, Kelly, Tamminga, Carol A., Russo, Scott J., Maze, Ian

“…Mood disorders are an enigmatic class of debilitating illnesses that affect millions of individuals worldwide. While chronic stress clearly increases incidence…”
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Dissociable contributions of the amygdala and ventral hippocampus to stress-induced changes in defensive behavior by Pennington, Zachary T., LaBanca, Alexa R., Sompolpong, Patlapa, Abdel-Raheim, Shereen D., Ko, Bumjin, Christenson Wick, Zoe, Feng, Yu, Dong, Zhe, Francisco, Taylor R., Bacon, Madeline E., Chen, Lingxuan, Fulton, Sasha L., Maze, Ian, Shuman, Tristan, Cai, Denise J.

“…Stress can have profound consequences on mental health. While much is known about the neural circuits supporting associative memories of stressful events, our…”
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Early Life Stress and the Fate of Kynurenine Pathway Metabolites by Coplan, Jeremy D, George, Roza, Syed, Shariful A, Rozenboym, Annalam V, Tang, Jean E, Fulton, Sasha L, Perera, Tarique D

“…Early life stress (ELS) precedes alterations to neuro-immune activation, which may mediate an increased risk for stress-related psychiatric disorders,…”
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Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome by Fulton, Sasha L., Wenderski, Wendy, Lepack, Ashley E., Eagle, Andrew L., Fanutza, Tomas, Bastle, Ryan M., Ramakrishnan, Aarthi, Hays, Emma C., Neal, Arianna, Bendl, Jaroslav, Farrelly, Lorna A., Al-Kachak, Amni, Lyu, Yang, Cetin, Bulent, Chan, Jennifer C., Tran, Tina N., Neve, Rachael L., Roper, Randall J., Brennand, Kristen J., Roussos, Panos, Schimenti, John C., Friedman, Allyson K., Shen, Li, Blitzer, Robert D., Robison, Alfred J., Crabtree, Gerald R., Maze, Ian

“…With an incidence of ~1 in 800 births, Down syndrome (DS) is the most common chromosomal condition linked to intellectual disability worldwide. While the…”
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Epigenetics of Drug Addiction by Stewart, Andrew F, Fulton, Sasha L, Maze, Ian

“…Substance use disorders (SUDs) are chronic brain diseases characterized by transitions from recreational to compulsive drug use and aberrant drug craving that…”
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Elevated cerebrospinal fluid 5-hydroxyindoleacetic acid in macaques following early life stress and inverse association with hippocampal volume: preliminary implications for serotonin-related function in mood and anxiety disorders by Coplan, Jeremy D, Fulton, Sasha L, Reiner, Wade, Jackowski, Andrea, Panthangi, Venkatesh, Perera, Tarique D, Gorman, Jack M, Huang, Yung-Yu, Tang, Cheuk Y, Hof, Patrick R, Kaffman, Arie, Dwork, Andrew J, Mathew, Sanjay J, Kaufman, Joan, Mann, J John

“…Early life stress (ELS) is cited as a risk for mood and anxiety disorders, potentially through altered serotonin neurotransmission. We examined the effects of…”
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Translational Molecular Approaches in Substance Abuse Research by Fulton, Sasha L, Maze, Ian

“…Excessive abuse of psychoactive substances is one of the leading contributors to morbidity and mortality worldwide. In this book chapter, we review…”
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Glucagon-Like Peptide-1 as Predictor of Body Mass Index and Dentate Gyrus Neurogenesis: Neuroplasticity and the Metabolic Milieu by Kral, John G., Banerji, Mary Ann, Fulton, Sasha L., Perera, Tarique D., Syed, Shariful, Coplan, Jeremy D., Dwork, Andrew J.

“…Glucagon-like peptide-1 (GLP-1) regulates carbohydrate metabolism and promotes neurogenesis. We reported an inverse correlation between adult body mass and…”
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Histone H3 dopaminylation in nucleus accumbens, but not medial prefrontal cortex, contributes to cocaine-seeking following prolonged abstinence by Stewart, Andrew F., Lepack, Ashley E., Fulton, Sasha L., Safovich, Polina, Maze, Ian

“…Enduring patterns of epigenomic and transcriptional plasticity within the mesolimbic dopamine system contribute importantly to persistent behavioral…”
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Histone H3 dopaminylation in ventral tegmental area underlies heroin-induced transcriptional and behavioral plasticity in male rats by Fulton, Sasha L, Mitra, Swarup, Lepack, Ashley E, Martin, Jennifer A, Stewart, Andrew F, Converse, Jacob, Hochstetler, Mason, Dietz, David M, Maze, Ian

“…Persistent transcriptional events in ventral tegmental area (VTA) and other reward relevant brain regions contribute to enduring behavioral adaptations that…”
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Reduced left ventricular dimension and function following early life stress: A thrifty phenotype hypothesis engendering risk for mood and anxiety disorders by Coplan, Jeremy D., Rozenboym, Anna V., Fulton, Sasha L., Panthangi, Venkatesh, Tang, Jean, Thiramangalakdi, Lakshmi, Perera, Tarique D., Liu, Yang, Kamran, Haroon, Owens, Michael J., Nemeroff, Charles B., Rosenblum, Leonard A., Kral, John G., Salciccioli, Louis, Lazar, Jason

“…Early life stress (ELS) in macaques in the form of insecure maternal attachment putatively induces epigenetic adaptations resulting in a “thrifty phenotype”…”
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Maternal Cerebrospinal Fluid Glutamate in Response to Variable Foraging Demand: Relationship to Cerebrospinal Fluid Serotonin Metabolites in Grown Offspring by Coplan, Jeremy D., Gupta, Nishant K., Flynn, Sarah K., Reiner, Wade J., Gaita, David, Fulton, Sasha L., Rozenboym, Anna V., Tang, Jean E., Cooper, Thomas B., Mann, J. John

“…Background Maternal response to allostatic overload during infant rearing may alter neurobiological measures in grown offspring, potentially increasing…”
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Lifelong reductions of PKMζ in ventral hippocampus of nonhuman primates exposed to early-life adversity due to unpredictable maternal care by Fulton, Sasha L, Hsieh, Changchi, Atkin, Tobias, Norris, Ryan, Schoenfeld, Eric, Tsokas, Panayiotis, Fenton, André Antonio, Sacktor, Todd Charlton, Coplan, Jeremy D

“…Protein kinase Mζ (PKMζ) maintains long-term potentiation (LTP) and long-term memory through persistent increases in kinase expression. Early-life adversity is…”
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Developmental Antecedents of Adult Macaque Neurogenesis: Early-Life Adversity, 5-HTTLPR Polymorphisms, and Adolescent Hippocampal Volume by Schoenfeld, Eric M., Gupta, Nishant K., Syed, Shariful A., Rozenboym, Anna V., Fulton, Sasha L., Jackowski, Andrea P., Perera, Tarique D., Coplan, Jeremy D.

“…•Early-life adversity and short 5-HTTLPR allele concertedly attenuate neurogenesis•Normalized adolescent hippocampal volume predicts ipsilateral adult…”
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Lifelong Reductions of PKM[zeta] in Ventral Hippocampus of Nonhuman Primates Exposed to Early-Life Adversity Due to Unpredictable Maternal Care by Fulton, Sasha L, Hsieh, Changchi, Atkin, Tobias, Norris, Ryan, Schoenfeld, Eric, Tsokas, Panayiotis, Fenton, André Antonio, Sacktor, Todd Charlton, Coplan, Jeremy D

“…Protein kinase M[zeta] (PKM[zeta]) maintains long-term potentiation (LTP) and long-term memory through persistent increases in kinase expression. Early-life…”
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Identification of Novel Cell-Type Specific Epigenetic Regulators of Neuropsychiatric and Neurodevelopmental Disease by Fulton, Sasha L

“…The overarching goal of this thesis work has been to leverage epigenetic profiling to investigate novel cell-type specific mechanisms in diseases of the…”
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