Search Results - "Fuller, Claudette L"

Nonclinical Studies that Support Viral Vector-Delivered Gene Therapies: An EFPIA Gene Therapy Working Group Perspective by Bolt, Michael W., Whiteley, Laurence O., Lynch, Jessica L., Lauritzen, Brian, Fernández de Henestrosa, Antonio R., MacLachlan, Timothy, Ulrich, Peter, Philip, Binu K., Mahalingaiah, Prathap Kumar, Fuller, Claudette L., Compton, David R.

“…Nonclinical development strategies for gene therapies are unique from other modalities. The European Federation of Pharmaceutical Industries and Associates…”
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Activation of Triggering Receptor Expressed on Myeloid Cells-1 on Human Neutrophils by Marburg and Ebola Viruses by MOHAMADZADEH, Mansour, COBERLEY, Sadie S, OLINGER, Gene G, KALINA, Warren V, RUTHEL, Gordon, FULLER, Claudette L, SWENSON, Dana L, PRATT, William D, KUHNS, Douglas B, SCHMALJOHN, Alan L

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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NKp30-dependent cytolysis of filovirus-infected human dendritic cells by Fuller, Claudette L, Ruthel, Gordon, Warfield, Kelly L, Swenson, Dana L, Bosio, Catharine M, Aman, M. Javad, Bavari, Sina

“…Understanding how protective innate immune responses are generated is crucial to defeating highly lethal emerging pathogens. Accumulating evidence suggests…”
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All roads lead to actin: the intimate relationship between TCR signaling and the cytoskeleton by Fuller, Claudette L., Braciale, Vivian L., Samelson, Lawrence E.

“…Regardless of cell type, the regulation of the actin cytoskeleton is tightly linked to vital biological properties such as polarity, motility, cell–cell…”
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Current nonclinical approaches for immune assessments of immuno-oncology biotherapeutics by Grimaldi, Christine, Ibraghimov, Alex, Kiessling, Andrea, Rattel, Benno, Ji, Changhua, Fuller, Claudette L., Brennan, Frank R., Regenass-Lechner, Franziska, Shenton, Jacintha, Price, Karen D., Piché, Marie-Soleil, Steeves, Meredith A., Prell, Rodney, Dudal, Sherri, Kronenberg, Sven, Freebern, Wendy, Blanset, Diann

“…•Cancer immunotherapy is associated with immune-related adverse events.•Current nonclinical approaches for assessment of these adverse events are reviewed in…”
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Challenges and gaps in immunosafety evaluation of therapeutics: An IQ DruSafe survey by Collinge, Mark, Neff-LaFord, Haley, Akella, Surekha, Fogal, Birgit, Fraser, Kathryn, Jabbour, Jacob, Harper, Kirsty, Maier, Curtis C., Malherbe, Laurent, Marshall, Nikki, Rao, Gautham K., Raman, Kavita, Skaggs, Hollie, Weber, Felix, Fuller, Claudette L.

“…Immunotoxicology/immunosafety science is rapidly evolving, with novel modalities and immuno-oncology among the primary drivers of new tools and technologies…”
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Dendritic Cells Endocytose Bacillus anthracis Spores: Implications for Anthrax Pathogenesis by Brittingham, Katherine C, Ruthel, Gordon, Panchal, Rekha G, Fuller, Claudette L, Ribot, Wilson J, Hoover, Timothy A, Young, Howard A, Anderson, Arthur O, Bavari, Sina

“…Phagocytosis of inhaled Bacillus anthracis spores and subsequent trafficking to lymph nodes are decisive events in the progression of inhalational anthrax…”
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A LAT Mutation That Inhibits T Cell Development Yet Induces Lymphoproliferation by Sommers, Connie L., Park, Cheung-Seog, Lee, Jan, Feng, Chiguang, Fuller, Claudette L., Grinberg, Alexander, Hildebrand, Jay A., Lacaná, Emanuela, Menon, Rashmi K., Shores, Elizabeth W., Samelson, Lawrence E., Love, Paul E.

“…Mice homozygous for a single tyrosine mutation in LAT (linker for activation of T cells) exhibited an early block in T cell maturation but later developed a…”
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Mutation of the phospholipase C-γ1–binding site of LAT affects both positive and negative thymocyte selection by Sommers, Connie L., Lee, Jan, Steiner, Kevin L., Gurson, Jordan M., DePersis, Corinne L., El-Khoury, Dalal, Fuller, Claudette L., Shores, Elizabeth W., Love, Paul E., Samelson, Lawrence E.

“…Linker for activation of T cells (LAT) is a scaffolding adaptor protein that is critical for T cell development and function. A mutation of LAT (Y136F) that…”
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Transcriptome analysis of human immune responses following live vaccine strain (LVS) Francisella tularensis vaccination by Fuller, Claudette L., Brittingham, Katherine C., Porter, Mark W., Hepburn, Matthew J., Petitt, Patricia L., Pittman, Phillip R., Bavari, Sina

“…The live vaccine strain (LVS) of Francisella tularensis is the only vaccine against tularemia available for humans, yet its mechanism of protection remains…”
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Dominance of human innate immune responses in primary Francisella tularensis live vaccine strain vaccination by Fuller, Claudette L., Brittingham, Katherine C., Hepburn, Matthew J., Martin, James W., Petitt, Patricia L., Pittman, Phillip R., Bavari, Sina

“…An inoculum as small as 10 bacteria can cause a flulike disease with substantial morbidity and mortality among infected humans.1,2 Human tularemia presents in…”
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Selective Induction of CD8+ Cytotoxic T Lymphocyte Effector Function by Staphylococcus Enterotoxin B by Fuller, Claudette L, Braciale, Vivian Lam

“…Upon encounter with its antigenic stimulus, CTL characteristically proliferate, produce cytokines, and lyse the Ag-presenting cell in an attempt to impede…”
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Phosphatidylinositol 3-Kinase-Dependent and -Independent Cytolytic Effector Functions by Fuller, Claudette L, Ravichandran, Kodimangalam S, Braciale, Vivian L

“…Two distinct forms of short-term cytolysis have been described for CD8+ CTLs, the perforin/granzyme- and Fas ligand/Fas (CD95 ligand (CD95L)/CD95)-mediated…”
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Suppressed clinical experimental autoimmune myasthenia gravis in bm12 mice is linked to reduced intracellular calcium mobilization and IL-10 and IFN-γ release by acetylcholine receptor-specific T cells by Poussin, Mathilde A, Fuller, Claudette L, Goluszko, Elzbieta, Reyes, Victor E, Braciale, Vivian L, Christadoss, Premkumar

“…Class II MHC mutant bm12 mice have an increased resistance to experimental autoimmune myasthenia gravis (EAMG) compared to C57BL/6 mice. In vitro, this…”
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Generation of IL-2-Dependent Cytolytic T Lymphocytes (CTLs) with Altered TCR Responses Derived from Antigen-Dependent CTL Clones by Gullo, Charles A, Esser, Mark T, Fuller, Claudette L, Braciale, Vivian Lam

“…Ag-specific CD8+ CTL clones require TCR stimulation to respond to IL-2 for growth. Because IL-2 may be produced in the vicinity of CD8+ CTLs when Ag is…”
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High-resolution multicolor imaging of dynamic signaling complexes in T cells stimulated by planar substrates by Bunnell, Stephen C, Barr, Valarie A, Fuller, Claudette L, Samelson, Lawrence E

“…The dynamic visualization of developing immunological synapses has been hindered by the difficulty of imaging the contact between the T cell and the…”
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Mutation of the phospholipase C- gamma 1-binding site of LAT affects both positive and negative thymocyte selection by Sommers, Connie L, Lee, Jan, Steiner, Kevin L, Gurson, Jordan M, DePersis, Corinne L, El-Khoury, Dalal, Fuller, Claudette L, Shores, Elizabeth W, Love, Paul E, Samelson, Lawrence E

“…Linker for activation of T cells (LAT) is a scaffolding adaptor protein that is critical for T cell development and function. A mutation of LAT (Y136F) that…”
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Ca2+ signaling modulates cytolytic T lymphocyte effector functions by Esser, M T, Haverstick, D M, Fuller, C L, Gullo, C A, Braciale, V L

“…Cytolytic T cells use two mechanisms to kill virally infected cells, tumor cells, or other potentially autoreactive T cells in short-term in vitro assays. The…”
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Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection by Sommers, Connie L, Lee, Jan, Steiner, Kevin L, Gurson, Jordan M, Depersis, Corinne L, El-Khoury, Dalal, Fuller, Claudette L, Shores, Elizabeth W, Love, Paul E, Samelson, Lawrence E

“…Linker for activation of T cells (LAT) is a scaffolding adaptor protein that is critical for T cell development and function. A mutation of LAT (Y136F) that…”
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