Search Results - "Fulcher, Yan G."

Charge-Triggered Membrane Insertion of Matrix Metalloproteinase-7, Supporter of Innate Immunity and Tumors by Prior, Stephen H., Fulcher, Yan G., Koppisetti, Rama K., Jurkevich, Alexander, Van Doren, Steven R.

“…Matrix metalloproteinase-7 (MMP-7) sheds signaling proteins from cell surfaces to activate bacterial killing, wound healing, and tumorigenesis. The mechanism…”
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Noninvasive Recognition and Biomarkers of Early Allergic Asthma in Cats Using Multivariate Statistical Analysis of NMR Spectra of Exhaled Breath Condensate by Fulcher, Yan G, Fotso, Martial, Chang, Chee-Hoon, Rindt, Hans, Reinero, Carol R, Van Doren, Steven R

“…Asthma is prevalent in children and cats, and needs means of noninvasive diagnosis. We sought to distinguish noninvasively the differences in 53 cats before…”
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Fusion Peptide of SARS-CoV‑2 Spike Rearranges into a Wedge Inserted in Bilayered Micelles by Koppisetti, Rama K, Fulcher, Yan G, Van Doren, Steven R

“…The receptor binding and proteolysis of Spike of SARS-CoV-2 release its S2 subunit to rearrange and catalyze viral-cell fusion. This deploys the fusion peptide…”
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The BADC and BCCP subunits of chloroplast acetyl-CoA carboxylase sense the pH changes of the light–dark cycle by Ye, Yajin, Fulcher, Yan G., Sliman, David J., Day, Mizani T., Schroeder, Mark J., Koppisetti, Rama K., Bates, Philip D., Thelen, Jay J., Van Doren, Steven R.

“…Acetyl-CoA carboxylase (ACCase) catalyzes the first committed step in the de novo synthesis of fatty acids. The multisubunit ACCase in the chloroplast is…”
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Peripheral membrane associations of matrix metalloproteinases by Van Doren, Steven R., Marcink, Tara C., Koppisetti, Rama K., Jurkevich, Alexander, Fulcher, Yan G.

“…Water soluble matrix metalloproteinases (MMPs) have been regarded as diffusing freely in the extracellular matrix. Yet multiple MMPs are also observed at cell…”
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Ambidextrous binding of cell and membrane bilayers by soluble matrix metalloproteinase-12 by Koppisetti, Rama K., Fulcher, Yan G., Jurkevich, Alexander, Prior, Stephen H., Xu, Jia, Lenoir, Marc, Overduin, Michael, Van Doren, Steven R.

“…Matrix metalloproteinases (MMPs) regulate tissue remodelling, inflammation and disease progression. Some soluble MMPs are inexplicably active near cell…”
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MT1-MMP Binds Membranes by Opposite Tips of Its β Propeller to Position It for Pericellular Proteolysis by Marcink, Tara C., Simoncic, Jayce A., An, Bo, Knapinska, Anna M., Fulcher, Yan G., Akkaladevi, Narahari, Fields, Gregg B., Van Doren, Steven R.

“…Critical to migration of tumor cells and endothelial cells is the proteolytic attack of membrane type 1 matrix metalloproteinase (MT1-MMP) upon collagen,…”
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Glycan Activation of a Sheddase: Electrostatic Recognition between Heparin and proMMP-7 by Fulcher, Yan G., Prior, Stephen H., Masuko, Sayaka, Li, Lingyun, Pu, Dennis, Zhang, Fuming, Linhardt, Robert J., Van Doren, Steven R.

“…Heparan sulfate proteoglycans activate the matrix metalloproteinase-7 zymogen (proMMP-7) and recruit it in order to shed proteins from cell surfaces. This…”
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Copper transport into the secretory pathway is regulated by oxygen in macrophages by White, Carine, Kambe, Taiho, Fulcher, Yan G, Sachdev, Sherri W, Bush, Ashley I, Fritsche, Kevin, Lee, Jaekwon, Quinn, Thomas P, Petris, Michael J

“…Copper is an essential nutrient for a variety of biochemical processes; however, the redox properties of copper also make it potentially toxic in the free…”
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Remote Exosites of the Catalytic Domain of Matrix Metalloproteinase-12 Enhance Elastin Degradation by Fulcher, Yan G, Van Doren, Steven R

“…How does matrix metalloproteinase-12 (MMP-12 or metalloelastase) degrade elastin with high specific activity? Nuclear magnetic resonance suggested soluble…”
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Mapping Lipid Bilayer Recognition Sites of Metalloproteinases and Other Prospective Peripheral Membrane Proteins by Marcink, Tara C, Koppisetti, Rama K, Fulcher, Yan G, Van Doren, Steven R

“…Peripheral binding of proteins to lipid bilayers is critical not only in intracellular signaling but also in metalloproteinase shedding of signaling proteins…”
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NMR and Bioinformatics Discovery of Exosites That Tune Metalloelastase Specificity for Solubilized Elastin and Collagen Triple Helices by Palmier, Mark O., Fulcher, Yan G., Bhaskaran, Rajagopalan, Duong, Vinh Q., Fields, Gregg B., Van Doren, Steven R.

“…The catalytic domain of metalloelastase (matrix metalloproteinase-12 or MMP-12) is unique among MMPs in exerting high proteolytic activity upon fibrils that…”
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Solubilized elastin substrate for continuous fluorimetric assay of kinetics of elastases by Palmier, Mark O., Fulcher, Yan G., Van Doren, Steven R.

“…Elastolysis is central to progression of emphysema and aortic aneurysms. Characterization of steady-state enzyme kinetics of elastolysis is fettered by the…”
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Heparinoids Activate a Protease, Secreted by Mucosa and Tumors, via Tethering Supplemented by Allostery by Fulcher, Yan G, Sanganna Gari, Raghavendar Reddy, Frey, Nathan C, Zhang, Fuming, Linhardt, Robert J, King, Gavin M, Van Doren, Steven R

“…Activation by glycosaminoglycans (GAGs) is an emerging trend among extracellular proteases important in disease. ProMMP-7, the zymogen of a matrix…”
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Fusion peptide from SARS-2 spike transforms into a wedge inserted in a bilayer leaflet, and thins the opposite leaflet by Doren, Steven R. Van, Scott, Benjamin, Fulcher, Yan G., Koppisetti, Rama K.

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Transient Interactions of Metalloproteinases with Bilayers, Captured by Paramagnetic NMR, Include Dual Modes of Binding, Electrostatic Recruiting, and Allostery by Van Doren, Steven R., Prior, Stephen H., Fulcher, Yan G., Xu, Jia, Marcink, Tara C., Koppisetti, Rama K.

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Homogeneous, Sulfated Oligosaccharides from Glycosaminoglycans Activate Promatrilysin (proMMP‐7) Largely by Co‐localization by Fulcher, Yan G, Zhang, Fuming, Linhardt, Robert J, Gari, Raghavendar Reddy Sanganna, Prior, Stephen H, Jeong, Young J, King, Gavin M, Van Doren, Steven R

“…Abstract only Human matrix metalloproteinase‐7 (MMP‐7 or matrilysin) and glycosaminolycans (GAGs) are two important players in extracellular matrix (ECM),…”
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